Cytokines and T cells in host defense

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice

1998 • 914 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency

1998 • 837 citations

Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

1998 • 812 citations

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.

1998 • 775 citations

T-cell co-stimulation through B7RP-1 and ICOS

1999 • 758 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

IL-12 Up-Regulates IL-18 Receptor Expression on T Cells, Th1 Cells, and B Cells: Synergism with IL-18 for IFN-γ Production

1998 • 636 citations

T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function

1998 • 601 citations

IL-13, IL-4Rα, and Stat6 Are Required for the Expulsion of the Gastrointestinal Nematode Parasite Nippostrongylus brasiliensis

1998 • 582 citations

A Kinetic Basis For T Cell Receptor Repertoire Selection during an Immune Response

1999 • 515 citations

Selective Expression of a Stable Cell Surface Molecule on Type 2 but Not Type 1 Helper T Cells

1998 • 514 citations

B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα

1999 • 440 citations

Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection.

1998 • 427 citations

Class II-Independent Generation of CD4 Memory T Cells from Effectors

1999 • 422 citations

T Cell Affinity Maturation by Selective Expansion during Infection

1999 • 420 citations

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.

1998 • 405 citations

Linear Differentiation of Cytotoxic Effectors into Memory T Lymphocytes

1999 • 393 citations

Selective Expression and Functions of Interleukin 18 Receptor on T Helper (Th) Type 1 but not Th2 Cells

1998 • 356 citations

OX40-Deficient Mice Are Defective in Th Cell Proliferation but Are Competent in Generating B Cell and CTL Responses after Virus Infection

1999 • 320 citations

Two Roads Diverged: Interferon α/β– and Interleukin 12–mediated Pathways in Promoting T Cell Interferon γ Responses during Viral Infection

1999 • 299 citations

Cutting Edge: IL-12 Is Required for the Maintenance of IFN-γ Production in T Cells Mediating Chronic Resistance to the Intracellular Pathogen,Toxoplasma gondii

2000 • 296 citations

Analysis of 4-1BB Ligand (4-1BBL)-Deficient Mice and of Mice Lacking Both 4-1BBL and CD28 Reveals a Role for 4-1BBL in Skin Allograft Rejection and in the Cytotoxic T Cell Response to Influenza Virus

1999 • 280 citations

Attrition of T Cell Memory

1999 • 278 citations

TRANCE, a Tumor Necrosis Factor Family Member Critical for CD40 Ligand–independent T Helper Cell Activation

1999 • 262 citations

4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses

1999 • 259 citations

Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling.

1999 • 249 citations

Role of Interleukin-18 (IL-18) in Mycobacterial Infection in IL-18-Gene-Disrupted Mice

1999 • 249 citations

IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice.

1998 • 238 citations

Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection

1998 • 238 citations

Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis

2000 • 235 citations

Following the Development of a CD4 T Cell Response In Vivo

1999 • 213 citations

IL-12 Is Required to Maintain a Th1 Response DuringLeishmania majorInfection

2000 • 207 citations

Interleukin 18 Contributes to Host Resistance and Gamma Interferon Production in Mice Infected with VirulentSalmonella typhimurium

1999 • 206 citations

Differences Between IL-4- and IL-4 Receptor α-Deficient Mice in Chronic Leishmaniasis Reveal a Protective Role for IL-13 Receptor Signaling

1999 • 204 citations

IL-18 (IFN-γ-Inducing Factor) Regulates Early Cytokine Production in, and Promotes Resolution of, Bacterial Infection in Mice

1998 • 195 citations

Stat6 Regulation of In Vivo IL-4 Responses

2000 • 194 citations

Altered Immune Responses and Susceptibility toLeishmania majorandStaphylococcus aureusInfection in IL-18-Deficient Mice

1999 • 173 citations

Viral infections in interferon-γ receptor deficiency

1999 • 173 citations

A Signal Transducer and Activator of Transcription (Stat)4-independent Pathway for the Development of T Helper Type 1 Cells

1998 • 172 citations

Lineage-specific Requirement for Signal Transducer and Activator of Transcription (Stat)4 in Interferon γ Production from CD4+ Versus CD8+ T Cells

1999 • 168 citations

Robust B Cell Immunity but Impaired T Cell Proliferation in the Absence of CD134 (OX40)

1999 • 167 citations

Defective Interleukin (IL)-18–mediated Natural Killer and T Helper Cell Type 1 Responses in IL-1 Receptor–associated Kinase (IRAK)-deficient Mice

1999 • 164 citations

IL-4- and IL-4 Receptor-Deficient BALB/c Mice Reveal Differences in Susceptibility to Leishmania major Parasite Substrains

1999 • 156 citations

IL-13 Is a Susceptibility Factor forLeishmania majorInfection

2000 • 156 citations

The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12.

1998 • 151 citations

IL-12 Is Not Required for Induction of Type 1 Cytokine Responses in Viral Infections

1999 • 147 citations

IL-18 Promotes Type 1 Cytokine Production from NK Cells and T Cells in Human Intracellular Infection

1999 • 141 citations

Blockade of CTLA-4 Enhances Host Resistance to the Intracellular Pathogen,Leishmania donovani

1998 • 135 citations

Defects of T-cell effector function and post-thymic maturation in X-linked hyper-IgM syndrome

1999 • 115 citations

The IL-4 Rapidly Produced in BALB/c Mice After Infection with Leishmania major Down-Regulates IL-12 Receptor β2-Chain Expression on CD4+ T Cells Resulting in a State of Unresponsiveness to IL-12

1998 • 112 citations

CD40-CD40 Ligand Interaction Is Central to Cell-Mediated Immunity Against Toxoplasma gondii: Patients with Hyper IgM Syndrome Have a Defective Type 1 Immune Response That Can Be Restored by Soluble CD40 Ligand Trimer

1999 • 112 citations

Potentiality of Interleukin-18 as a Useful Reagent for Treatment and Prevention ofLeishmania majorInfection

2000 • 94 citations

CD40 Ligand Is Pivotal to Efficient Control of Virus Replication in Mice Infected with Lymphocytic Choriomeningitis Virus

1998 • 86 citations

Genetically Resistant Mice Lacking IL-18 Gene Develop Th1 Response and Control CutaneousLeishmania majorInfection

2000 • 83 citations

Dealing from the Evolutionary Pawnshop

1999 • 81 citations

IL-15 Prolongs the Duration of CD8+ T Cell-Mediated Immunity in Mice Infected with a Vaccine Strain ofToxoplasma gondii

1999 • 78 citations

Critical Role of CD28 in Protective Immunity AgainstSalmonella typhimurium

1999 • 76 citations

Combined effects of IL-12 and IL-18 on the clinical course and local cytokine production in murine pulmonary infection withCryptococcus neoformans

1999 • 75 citations

Differential Regulation of the Interleukin-12 Receptor during the Innate Immune Response toLeishmania major

1998 • 73 citations

T1/ST2 Expression Is Enhanced on CD4+ T Cells from Schistosome Egg-Induced Granulomas: Analysis of Th Cell Cytokine Coexpression Ex Vivo

1999 • 71 citations

Role of CD28 in the Generation of Effector and Memory Responses Required for Resistance toToxoplasma gondii

1999 • 66 citations

Augmentation of the CD8+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infection.

1999 • 66 citations

Role of Endogenous Interleukin-18 in Resolving Wild-Type and Attenuated Salmonella typhimurium Infections

1999 • 59 citations

Augmentation of the CD8+ T Cell Response by IFN-γ in IL-12-Deficient Mice DuringToxoplasma gondiiInfection

1999 • 59 citations

BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major.

1999 • 44 citations

The CD28/B7 Interaction Is Not Required for Resistance toToxoplasma gondiiin the Brain but Contributes to the Development of Immunopathology

1999 • 43 citations

CTLA4 (CD152) modulates the Th subset response and alters the course of experimentalLeishmania major infection

1998 • 37 citations

BCL-6-Deficient Mice Reveal an IL-4-Independent, STAT6-Dependent Pathway That Controls Susceptibility to Infection by Leishmania major

1999 • 35 citations

Interleukin-4-Independent Acceleration of Cutaneous Leishmaniasis in Susceptible BALB/c Mice following Treatment with Anti-CTLA4 Antibody

1999 • 22 citations