CD40 Ligand Is Pivotal to Efficient Control of Virus Replication in Mice Infected with Lymphocytic Choriomeningitis Virus

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

1984 • 782 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.

1995 • 650 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

1996 • 329 citations

CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation

1992 • 327 citations

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice

1994 • 321 citations

CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

1996 • 300 citations

Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice.

1996 • 237 citations

T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses

1988 • 205 citations

A critical role for neutralizing-antibody-producing B cells, CD4⁺T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: Implications for adoptive immunotherapy of virus carriers

1997 • 202 citations

Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice.

1996 • 185 citations

Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response

1987 • 185 citations

STUDIES ON CELL-MEDIATED IMMUNITY TO LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN MICE

1973 • 167 citations

CD8 T cell memory in B cell-deficient mice.

1996 • 158 citations

CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection

1996 • 154 citations

CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions.

1996 • 149 citations

Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA‐1

1995 • 132 citations

Changes in cell adhesion molecule expression on T cells associated with systemic virus infection.

1994 • 113 citations

Properties of mouse CD40: Cellular distribution of CD40 and B cell activation by monoclonal anti‐mouse CD40 antibodies

1994 • 112 citations

CD8+ T lymphocytes provide helper activity for IgE synthesis in human immunodeficiency virus-infected patients with hyper-IgE.

1995 • 105 citations

IL-4-producing CD8+ T cell clones can provide B cell help.

1995 • 98 citations

In vivo expression of perforin by CD8+ lymphocytes during an acute viral infection.

1989 • 93 citations

Role of virus and host variables in virus persistence or immunopathological disease caused by a non-cytolytic virus

1995 • 81 citations

Lymphocytic choriomeningitis virus killer T cells are lethal only in weakly disseminated murine infections.

1982 • 77 citations

Expression of type 3 complement receptor on activated CD8+ T cells facilitates homing to inflammatory sites.

1994 • 74 citations

The Role of CD4⁺ T Cells in Cell‐Mediated Immunity to LCM V: Studies in MHC Class I and Class II Deficient Mice

1994 • 71 citations

Cytotoxicity and weak CD40 ligand expression of CD8⁺ type 2 cytotoxic T cells restricts their potential B cell helper activity

1997 • 62 citations

Lymphocytic Choriomeningitis Virus Infection is Associated with Long‐Standing Perturbation of LFA‐1 Expression on CD8⁺ T Cells

1995 • 58 citations

CD40 ligand has potent antiviral activity

1995 • 48 citations

Virus-activated T cells regulate expression of adhesion molecules on endothelial cells in sites of infection

1995 • 47 citations

MHC and non-MHC genes regulate elimination of lymphocytic choriomeningitis virus and antiviral cytotoxic T lymphocyte and delayed-type hypersensitivity mediating T lymphocyte activity in parallel.

1989 • 36 citations

Characterization of virus-primed CD8⁺ T cells with a type 1 cytokine profile

1996 • 33 citations

Virus-induced polyclonal T cell activation is followed by apoptosis: partitioning of CD8⁺ T cells based on α4 integrin expression

1996 • 28 citations

The Combination of Major Histocompatibility Complex (MHC) and Non‐MHC Genes Influences Murine Lymphocytic Choriomeningitis Virus Pathogenesis

1989 • 10 citations

Non-MHC genes influence virus clearance through regulation of the antiviral T-cell response: correlation between virus clearance and Tc and Td activity in segregating backcross progeny.

1994 • 1 citations