Interleukin-4-Independent Acceleration of Cutaneous Leishmaniasis in Susceptible BALB/c Mice following Treatment with Anti-CTLA4 Antibody

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

Requirement for IL-13 Independently of IL-4 in Experimental Asthma

1998 • 1,869 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

Molecular Basis of T Cell Inactivation by CTLA-4

1998 • 678 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

IL-13, IL-4Rα, and Stat6 Are Required for the Expulsion of the Gastrointestinal Nematode Parasite Nippostrongylus brasiliensis

1998 • 582 citations

Development of a Natural Model of Cutaneous Leishmaniasis: Powerful Effects of Vector Saliva and Saliva Preexposure on the Long-Term Outcome of Leishmania major Infection in the Mouse Ear Dermis

1998 • 409 citations

CTLA-4: a negative regulator of autoimmune disease.

1996 • 382 citations

Requirement for IL-13 independently of IL-4 in experimental asthma

1999 • 350 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

Susceptibility to Leishmania major Infection in Interleukin-4-Deficient Mice

1996 • 292 citations

A Critical Role for IL-13 in Resistance to Intestinal Nematode Infection

1998 • 284 citations

Modulation of murine macrophage function by IL-13.

1993 • 251 citations

Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis.

1994 • 234 citations

A possible novel pathway of regulation by murine T helper type‐2 (T_h2) cells of a T_h1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages

1991 • 226 citations

IL-13 Is a Key Regulatory Cytokine for Th2 Cell-Mediated Pulmonary Granuloma Formation and IgE Responses Induced bySchistosoma mansoniEggs

1999 • 216 citations

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28

1998 • 185 citations

B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28

1998 • 179 citations

B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens.

1997 • 172 citations

Murine cutaneous leishmaniasis: resistance correlates with the capacity to generate interferon-gamma in response to Leishmania antigens in vitro.

1986 • 169 citations

Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.

1995 • 162 citations

IL-4- and IL-4 Receptor-Deficient BALB/c Mice Reveal Differences in Susceptibility to Leishmania major Parasite Substrains

1999 • 156 citations

Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) Interferes with Extracellular Signal-regulated Kinase (ERK) and Jun NH2-terminal Kinase (JNK) Activation, but Does Not Affect Phosphorylation of T Cell Receptor ζ and ZAP70

1997 • 153 citations

The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12.

1998 • 151 citations

CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction.

1998 • 137 citations

Blockade of CTLA-4 Enhances Host Resistance to the Intracellular Pathogen,Leishmania donovani

1998 • 135 citations

Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo

1996 • 132 citations

Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade

1997 • 113 citations

The IL-4 Rapidly Produced in BALB/c Mice After Infection with Leishmania major Down-Regulates IL-12 Receptor β2-Chain Expression on CD4+ T Cells Resulting in a State of Unresponsiveness to IL-12

1998 • 112 citations

Limited role of CD28-mediated signals in T helper subset differentiation.

1996 • 111 citations

Cutting Edge: CTLA-4 Ligation Delivers a Unique Signal to Resting Human CD4 T Cells That Inhibits Interleukin-2 Secretion but Allows Bcl-XL Induction

1998 • 111 citations

Blockade of CD86 Ameliorates Leishmania major Infection by Down-Regulating the Th2 Response

1996 • 74 citations

CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response.

1997 • 70 citations

CD28-independent Induction of T Helper Cells and Immunoglobulin Class Switches Requires Costimulation by the Heat-stable Antigen

1998 • 70 citations

B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression.

1997 • 55 citations

Expression and Contribution of B7-1 (CD80) and B7-2 (CD86) in the Early Immune Response to Leishmania major Infection

1999 • 55 citations

Characterization of T cell-mediated responses in nonhealing and healing Leishmania major infections in the absence of endogenous IL-4.

1997 • 54 citations

B7–CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge

1998 • 51 citations

Do effector and memory T helper cells also need B7 ligand costimulatory signals?

1997 • 50 citations

Is CTLA-4 a negative regulator for T-cell activation?

1997 • 49 citations

CTLA4 (CD152) modulates the Th subset response and alters the course of experimentalLeishmania major infection

1998 • 37 citations

Interleukin-13: Central mediator of allergic asthma

1999 • 7 citations