Augmentation of the CD8+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infection.

Applied Linear Statistical Models

1992 • 10,206 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1994 • 729 citations

Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.

1991 • 617 citations

Inducible Nitric Oxide Is Essential for Host Control of Persistent but Not Acute Infection with the Intracellular Pathogen Toxoplasma gondii

1997 • 432 citations

Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice.

1989 • 355 citations

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

1993 • 275 citations

Cytokine-Induced Synthesis of Nitrogen Oxides in Macrophages: A Protective Host Response to Leishmania and Other Intracellular Pathogens

1991 • 267 citations

Interleukin-12 enhances murine survival against acute toxoplasmosis

1994 • 203 citations

cDNA Cloning and Interferon γ Down-Regulation of Proteasomal Aubunits X and Y

1994 • 181 citations

Effect of Murine Interferon Gamma on Murine Toxoplasmosis

1984 • 179 citations

Establishment and Persistence of Virus‐Specific CD4⁺ and CD8⁺ T Cell Memory

1996 • 155 citations

A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection.

1996 • 154 citations

An Essential Role for Type 1 Interferon-γ in Terminating Persistent Viral Infection

1995 • 145 citations

Role of inorganic nitrogen oxides and tumor necrosis factor alpha in killing Leishmania donovani amastigotes in gamma interferon-lipopolysaccharide-activated macrophages from Lshs and Lshr congenic mouse strains

1991 • 139 citations

Interleukin-4 mediates down regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo

1996 • 132 citations

IL-15 augments CD8+ T cell-mediated immunity against Toxoplasma gondii infection in mice.

1996 • 132 citations

Regulation of the expression of class I MHC genes.

1990 • 129 citations

Single immunizing dose of recombinant adenovirus efficiently induces CD8+ T cell-mediated protective immunity against malaria.

1997 • 127 citations

Nitric Oxide and Viral Infection: No Antiviral Activity against a Flavivirusin Vitro,and Evidence for Contribution to Pathogenesis in Experimental Infectionin Vivo

1996 • 117 citations

Enhanced virus replication and inhibition of lymphocytic choriomeningitis virus disease in anti-gamma interferon-treated mice

1989 • 103 citations

Production of nitric oxide (NO) is not essential for protection against acute Toxoplasma gondii infection in IRF-1-/- mice.

1996 • 85 citations

Antigen-specific (p30) mouse CD8+ T cells are cytotoxic against Toxoplasma gondii-infected peritoneal macrophages.

1992 • 81 citations

Mucosal and systemic cellular immune responses induced by Toxoplasma gondii antigens in cyst orally infected mice.

1993 • 65 citations

Temperature-Sensitive Mutants of Toxoplasma gondii: Pathogenicity and Persistence in Mice

1983 • 55 citations

CD8 T-cell recognition of macrophages and hepatocytes results in immunity to Listeria monocytogenes

1996 • 52 citations

CD8+ T-cell interactions with Toxoplasma gondii: implications for processing of antigen for class-I-restricted recognition

1993 • 48 citations

Toxoplasma gondii:Evidence for Interleukin-12-Dependent and -Independent Pathways of Interferon-γ Production Induced by an Attenuated Parasite Strain

1996 • 45 citations

Infection of mice lacking the common cytokine receptor gamma-chain (gamma(c)) reveals an unexpected role for CD4+ T lymphocytes in early IFN-gamma-dependent resistance to Toxoplasma gondii.

1998 • 45 citations

Modulation by gamma interferon of antiviral cell-mediated immune responses in vivo

1996 • 28 citations

Two mechanisms for platelet‐mediated killing of tumour cells: one cyclo‐oxygenase dependent and the other nitric oxide dependent

1996 • 17 citations