Neuroscience of Behavioral and Pharmacological Treatments for Addictions

Prevalence, Severity, and Comorbidity of 12-Month DSM-IV Disorders in the National Comorbidity Survey Replication

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Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

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Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex

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The neural basis of drug craving: An incentive-sensitization theory of addiction

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Motivational interviewing: preparing people for change.

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Conflict monitoring and cognitive control.

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Cognitive and emotional influences in anterior cingulate cortex

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The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions

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Neurocircuitry of Addiction

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Treating tobacco use and dependence-Clinical practice guideline

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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

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The Reward Circuit: Linking Primate Anatomy and Human Imaging

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Delay of Gratification in Children

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Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions

1991 • 3,177 citations

Separate Neural Systems Value Immediate and Delayed Monetary Rewards

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Prevalence, Correlates, Disability, and Comorbidity of DSM-IV Alcohol Abuse and Dependence in the United States

2007 • 2,894 citations

Treating Tobacco Use and Dependence

2008 • 2,821 citations

Drug Addiction, Dysregulation of Reward, and Allostasis

2001 • 2,820 citations

The Preventable Causes of Death in the United States: Comparative Risk Assessment of Dietary, Lifestyle, and Metabolic Risk Factors

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mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

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Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex

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Treating Tobacco Use and Dependence: 2008 Update

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Psychiatric Aspects of Impulsivity

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Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.

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Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence

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Chapter 6 Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions

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The neural correlates of subjective value during intertemporal choice

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Dissecting components of reward: ‘liking’, ‘wanting’, and learning

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Chronic Stress, Drug Use, and Vulnerability to Addiction

2008 • 1,648 citations

Developmental Neurocircuitry of Motivation in Adolescence: A Critical Period of Addiction Vulnerability

2003 • 1,634 citations

The efficacy of motivational interviewing: A meta-analysis of controlled clinical trials.

2003 • 1,560 citations

Limbic Activation During Cue-Induced Cocaine Craving

1999 • 1,518 citations

Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence

2009 • 1,513 citations

Impulsivity, Compulsivity, and Top-Down Cognitive Control

2011 • 1,466 citations

Incentive‐sensitization and addiction

2001 • 1,397 citations

Impulse Control Disorders in Parkinson Disease

2010 • 1,350 citations

Impulsivity as a vulnerability marker for substance-use disorders: Review of findings from high-risk research, problem gamblers and genetic association studies

2008 • 1,341 citations

Impulsivity as a determinant and consequence of drug use: a review of underlying processes

2008 • 1,328 citations

Reconsidering anhedonia in depression: Lessons from translational neuroscience

2010 • 1,324 citations

A Meta-Analytic Review of Psychosocial Interventions for Substance Use Disorders

2008 • 1,212 citations

Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement

2007 • 1,157 citations

Atomoxetine Increases Extracellular Levels of Norepinephrine and Dopamine in Prefrontal Cortex of Rat A Potential Mechanism for Efficacy in Attention Deficit/Hyperactivity Disorder

2002 • 1,092 citations

Dorsal anterior cingulate cortex: A role in reward-based decision making

2001 • 1,062 citations

The genetics of addictions: uncovering the genes

2005 • 1,060 citations

Introduction to Behavioral Addictions

2010 • 1,056 citations

Modulation of Cortical-Limbic Pathways in Major Depression

2004 • 1,042 citations

Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction

2005 • 1,009 citations

High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking

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Plasticity of reward neurocircuitry and the 'dark side' of drug addiction

2005 • 940 citations

The Effectiveness of Methadone Maintenance Treatment: Patients, Programs, Services, and Outcome

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A time of change: Behavioral and neural correlates of adolescent sensitivity to appetitive and aversive environmental cues

2009 • 916 citations

The neural basis of human moral cognition

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The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation

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Dimensions of impulsive behavior: Personality and behavioral measures

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The Effects of Psychosocial Services in Substance Abuse Treatment

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A meta‐analysis of voucher‐based reinforcement therapy for substance use disorders

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The hidden island of addiction: the insula

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Learning sculpts the spontaneous activity of the resting human brain

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The role of impulsive behavior in drug abuse

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Delay discounting of money and alcohol in actively using alcoholics, currently abstinent alcoholics, and controls

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Neuroeconomics: The Consilience of Brain and Decision

2004 • 735 citations

'Behavioral' Addictions: Do They Exist?

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From First Drug Use to Drug Dependence Developmental Periods of Risk for Dependence upon Marijuana, Cocaine, and Alcohol

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Reward Mechanisms in Obesity: New Insights and Future Directions

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Remember the Future: Working Memory Training Decreases Delay Discounting Among Stimulant Addicts

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Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms

2008 • 675 citations

Prefrontal–striatal pathway underlies cognitive regulation of craving

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Anticipatory affect: neural correlates and consequences for choice

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Should addictive disorders include non‐substance‐related conditions?

2006 • 640 citations

Pathological gambling: Etiology, comorbidity, and treatment.

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Dopamine signals for reward value and risk: basic and recent data

2010 • 637 citations

Cognitive-Behavioral Treatment With Adult Alcohol and Illicit Drug Users: A Meta-Analysis of Randomized Controlled Trials

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Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review

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Is cognitive–behavioral therapy more effective than other therapies?A meta-analytic review

2010 • 603 citations

Drug addiction: the neurobiology of behaviour gone awry

2004 • 591 citations

Dopaminergic Network Differences in Human Impulsivity

2010 • 586 citations

A Functional Polymorphism of the μ-Opioid Receptor Gene is Associated with Naltrexone Response in Alcohol-Dependent Patients

2003 • 572 citations

A behavioral approach to achieving initial cocaine abstinence

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How Addictive Drugs Disrupt Presynaptic Dopamine Neurotransmission

2011 • 555 citations

Cognitive Enhancement Therapy for Schizophrenia

2004 • 541 citations

Cholinesterase inhibitors: new roles and therapeutic alternatives

2004 • 523 citations

Co-Occurring Mental and Substance Use Disorders: The Neurobiological Effects of Chronic Stress

2005 • 522 citations

Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence

2003 • 520 citations

A neurobiological basis for substance abuse comorbidity in schizophrenia

2001 • 519 citations

Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes

2006 • 519 citations

Treatment of Depression in Patients With Alcohol or Other Drug Dependence

2004 • 515 citations

Short-term meditation induces white matter changes in the anterior cingulate

2010 • 505 citations

Effects of Modafinil on Dopamine and Dopamine Transporters in the Male Human Brain

2009 • 499 citations

The neurobiology and genetics of impulse control disorders: Relationships to drug addictions

2007 • 490 citations

Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study

2009 • 488 citations

The neurobiology of pathological gambling and drug addiction: an overview and new findings

2008 • 482 citations

Amphetamine-Induced Increases in Extracellular Dopamine, Drug Wanting, and Novelty Seeking A PET/[11C]Raclopride Study in Healthy Men

2002 • 475 citations

Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics

2007 • 465 citations

Risky Business: Emotion, Decision-Making, and Addiction

2003 • 454 citations

Medications Versus Cognitive Behavior Therapy for Severely Depressed Outpatients: Mega-Analysis of Four Randomized Comparisons

1999 • 450 citations

Behavioral Therapies for Drug Abuse

2005 • 438 citations

Behavioral impulsivity predicts treatment outcome in a smoking cessation program for adolescent smokers

2006 • 430 citations

Pathological gamblers, with and without substance abuse disorders, discount delayed rewards at high rates.

2001 • 428 citations

Functional Magnetic Resonance Imaging of Cocaine Craving

2001 • 411 citations

Deficits in response inhibition associated with chronic methamphetamine abuse

2005 • 406 citations

Pathological gamblers, with and without substance use disorders, discount delayed rewards at high rates.

2001 • 403 citations

One-Year Follow-up of Psychotherapy and Pharmacotherapy for Cocaine Dependence

1994 • 402 citations

Brain Reactivity to Smoking Cues Prior to Smoking Cessation Predicts Ability to Maintain Tobacco Abstinence

2010 • 402 citations

Evidence for Plasticity in White‐Matter Tracts of Patients with Chronic Broca's Aphasia Undergoing Intense Intonation‐based Speech Therapy

2009 • 398 citations

Efficacy of relapse prevention: A meta-analytic review.

1999 • 395 citations

Use of fMRI to Predict Recovery From Unipolar Depression With Cognitive Behavior Therapy

2006 • 393 citations

Cognitive deficits predict low treatment retention in cocaine dependent patients

2005 • 388 citations

Computer-Assisted Delivery of Cognitive-Behavioral Therapy for Addiction: A Randomized Trial of CBT4CBT

2008 • 388 citations

A Double-Blind, Placebo-Controlled Trial of Modafinil for Cocaine Dependence

2004 • 386 citations

Epigenetic mechanisms in drug addiction

2008 • 372 citations

Use of fMRI to Predict Recovery From Unipolar Depression With Cognitive Behavior Therapy

2006 • 364 citations

Applications of real-time fMRI

2008 • 362 citations

Neurocognitive Enhancement Therapy With Work Therapy

2001 • 356 citations

Can food be addictive? Public health and policy implications

2011 • 355 citations

Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence

2003 • 355 citations

Pharmacotherapies for smoking cessation: a meta-analysis of randomized controlled trials

2008 • 316 citations

Individual differences in prefrontal cortex function and the transition from drug use to drug dependence

2010 • 307 citations

Prefrontal cortex activity is reduced in gambling and nongambling substance users during decision‐making

2007 • 304 citations

Efficacy of maintenance treatment with naltrexone for opioid dependence: a meta‐analytical review

2006 • 301 citations

Cue-Induced Brain Activity Changes and Relapse in Cocaine-Dependent Patients

2005 • 300 citations

Effects of Lower-Cost Incentives on Stimulant Abstinence in Methadone Maintenance Treatment

2006 • 298 citations

A placebo controlled trial of bupropion for smoking cessation in schizophrenia

2002 • 293 citations

N-Acetyl Cysteine, a Glutamate-Modulating Agent, in the Treatment of Pathological Gambling: A Pilot Study

2007 • 292 citations

Atomoxetine Modulates Right Inferior Frontal Activation During Inhibitory Control: A Pharmacological Functional Magnetic Resonance Imaging Study

2008 • 290 citations

Neural correlates of emotional processing in depression: Changes with cognitive behavioral therapy and predictors of treatment response

2010 • 289 citations

Mindfulness Training and Stress Reactivity in Substance Abuse: Results from a Randomized, Controlled Stage I Pilot Study

2009 • 277 citations

Atomoxetine Improved Response Inhibition in Adults with Attention Deficit/Hyperactivity Disorder

2007 • 276 citations

Problem gamblers share deficits in impulsive decision‐making with alcohol‐dependent individuals

2009 • 273 citations

Reduced Anterior Corpus Callosum White Matter Integrity is Related to Increased Impulsivity and Reduced Discriminability in Cocaine-Dependent Subjects: Diffusion Tensor Imaging

2004 • 263 citations

Current perspectives on selective dopamine D₃ receptor antagonists as pharmacotherapeutics for addictions and related disorders

2010 • 261 citations

Cocaine Vaccine for the Treatment of Cocaine Dependence in Methadone-Maintained Patients

2009 • 254 citations

Adolescence: What Do Transmission, Transition, and Translation Have to Do with It?

2010 • 252 citations

An fMRI Study of the Effects of Psychostimulants on Default-Mode Processing During Stroop Task Performance in Youths With ADHD

2009 • 250 citations

The Role of Cystine-Glutamate Exchange in Nicotine Dependence in Rats and Humans

2008 • 248 citations

Moderate drug use and delay discounting: A comparison of heavy, light, and never smokers.

2007 • 247 citations

Cocaine‐induced neuroadaptations in glutamate transmission

2010 • 237 citations

Preferential Effects of the Metabotropic Glutamate 2/3 Receptor Agonist LY379268 on Conditioned Reinstatement versus Primary Reinforcement: Comparison between Cocaine and a Potent Conventional Reinforcer

2004 • 236 citations

Neuroimaging studies of psychological interventions for mood and anxiety disorders: Empirical and methodological review

2007 • 230 citations

Naltrexone for the treatment of alcoholism: a meta-analysis of randomized controlled trials

2005 • 219 citations

Pretreatment Brain Activation During Stroop Task Is Associated with Outcomes in Cocaine-Dependent Patients

2008 • 217 citations

Modafinil for the treatment of cocaine dependence

2009 • 216 citations

Potential Vulnerabilities of Neuronal Reward, Risk, and Decision Mechanisms to Addictive Drugs

2011 • 213 citations

Varenicline Improves Mood and Cognition During Smoking Abstinence

2008 • 212 citations

Investigating the behavioral and self-report constructs of impulsivity domains using principal component analysis

2009 • 210 citations

A Cognitive-Behavioral Approach: Treating Cocaine Addiction

1998 • 207 citations

Addiction: Pulling at the Neural Threads of Social Behaviors

2011 • 206 citations

Vaccine Pharmacotherapy for the Treatment of Cocaine Dependence

2005 • 204 citations

Behavioral Addictions Debut in Proposed DSM-V

2010 • 203 citations

Pharmacotherapy of Alcohol Dependence

2004 • 203 citations

Effect of varenicline and bupropion SR on craving, nicotine withdrawal symptoms, and rewarding effects of smoking during a quit attempt

2007 • 200 citations

Delay discounting in current and former marijuana-dependent individuals.

2010 • 200 citations

High Dose Pimozide Does Not Block Amphetamine-Induced Euphoria in Normal Volunteers

1997 • 197 citations

Shared Genetic Contributions to Pathological Gambling and Major Depression in Men

2005 • 192 citations

Psychological Intervention and Antidepressant Treatment in Smoking Cessation

2002 • 192 citations

Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study

2002 • 192 citations

Medication Development for Addictive Disorders: The State of the Science

2005 • 192 citations

Activation of Group II Metabotropic Glutamate Receptors Attenuates Both Stress and Cue-Induced Ethanol-Seeking and Modulates c-fosExpression in the Hippocampus and Amygdala

2006 • 191 citations

Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study

2005 • 190 citations

Performance on the Stroop Predicts Treatment Compliance in Cocaine-Dependent Individuals

2007 • 188 citations

Using glutamate homeostasis as a target for treating addictive disorders

2010 • 188 citations

Metabotropic Glutamate 2/3 Receptors in the Ventral Tegmental Area and the Nucleus Accumbens Shell Are Involved in Behaviors Relating to Nicotine Dependence

2007 • 186 citations

Effects of ecopipam, a selective dopamine D1 antagonist, on smoked cocaine self-administration by humans

2001 • 185 citations

Agonist-Like or Antagonist-Like Treatment for Cocaine Dependence with Methadone for Heroin Dependence: Two Double-Blind Randomized Clinical Trials

2003 • 184 citations

Shared brain vulnerabilities open the way for nonsubstance addictions: Carving addiction at a new joint?

2010 • 183 citations

The Burden of Complex Genetics in Brain Disorders

2004 • 176 citations

A double-blind, placebo-controlled trial of modafinil for cocaine dependence

2012 • 175 citations

Memantine shows promise in reducing gambling severity and cognitive inflexibility in pathological gambling: a pilot study

2010 • 173 citations

Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors

2010 • 170 citations

A D2 Antagonist Enhances the Rewarding and Priming Effects of a Gambling Episode in Pathological Gamblers

2007 • 170 citations

Cognitive impairment influences drinking outcome by altering therapeutic mechanisms of change.

2006 • 169 citations

An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: A pilot study

2006 • 169 citations

Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence

2006 • 169 citations

Enduring effects of a computer-assisted training program for cognitive behavioral therapy: A 6-month follow-up of CBT4CBT

2008 • 168 citations

Predicting response to opiate antagonists and placebo in the treatment of pathological gambling

2008 • 167 citations

Six-Month Trial of Bupropion With Contingency Management for Cocaine Dependence in a Methadone-Maintained Population

2006 • 160 citations

Recovery from Chronic Demyelination by Thyroid Hormone Therapy: Myelinogenesis Induction and Assessment by Diffusion Tensor Magnetic Resonance Imaging

2008 • 158 citations

A double-blind, placebo-controlled trial of olanzapine for the treatment of video poker pathological gamblers

2008 • 156 citations

Rapid effects of brief intensive cognitive-behavioral therapy on brain glucose metabolism in obsessive-compulsive disorder

2008 • 155 citations

Imaging of Brain Dopamine Pathways

2009 • 153 citations

The Neuropsychology of Amphetamine and Opiate Dependence: Implications for Treatment

2007 • 152 citations

A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder

2006 • 150 citations

Brain macrostructural and microstructural abnormalities in cocaine dependence

2007 • 149 citations

Neurobiology of dysregulated motivational systems in drug addiction

2010 • 149 citations

Interaction of Amphetamines and Related Compounds at the Vesicular Monoamine Transporter

2006 • 143 citations

N‐Acetyl Cysteine‐Induced Blockade of Cocaine‐Induced Reinstatement

2003 • 142 citations

A framework for reporting outcomes in problem gambling treatment research: the Banff, Alberta Consensus

2006 • 142 citations

Pilot randomized double blind placebo‐controlled study of dexamphetamine for cocaine dependence

2003 • 140 citations

The effectiveness of methadone maintenance treatment

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Mindfulness‐based treatments for co‐occurring depression and substance use disorders: what can we learn from the brain?

2010 • 136 citations

Comparisons of Patients With Comorbid Psychiatric and Substance Use Disorders: Implications for Treatment and Service Delivery

2004 • 134 citations

Imaginal desensitisation plus motivational interviewing for pathological gambling: randomised controlled trial

2009 • 132 citations

Galantamine Enhances Dopaminergic Neurotransmission In Vivo Via Allosteric Potentiation of Nicotinic Acetylcholine Receptors

2006 • 124 citations

Cocaine-Specific Antibodies Blunt the Subjective Effects of Smoked Cocaine in Humans

2009 • 122 citations

Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor.

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Cocaine craving, euphoria, and self-administration: A preliminary study of the effect of catecholamine precursor depletion.

2005 • 120 citations

Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys

2008 • 119 citations

Effects of lofexidine on stress-induced and cue-induced opioid craving and opioid abstinence rates: preliminary findings

2006 • 118 citations

Synaptic plasticity in the mesolimbic system

2010 • 118 citations

Effect of Modafinil on Learning and Task-Related Brain Activity in Methamphetamine-Dependent and Healthy Individuals

2011 • 117 citations

Randomized controlled trial of dexamphetamine maintenance for the treatment of methamphetamine dependence

2009 • 116 citations

Temporal discounting as a measure of executive function: Insights from the competing neuro-behavioral decision system hypothesis of addiction

2008 • 116 citations

Efficacy of relapse prevention: A meta-analytic review.

1999 • 116 citations

Desipramine and contingency management for cocaine and opiate dependence in buprenorphine maintained patients

2003 • 113 citations

ACAMPROSATE DURING AND AFTER ACUTE ALCOHOL WITHDRAWAL: A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY IN SPAIN

2001 • 113 citations

Are alcoholism treatments effective? The Project MATCH data

2005 • 113 citations

Book review: Pathological gambling: etiology, comorbidity, and treatment by Nancy Petry. American Psychological Association, Washington, DC

2006 • 112 citations

Effect of Memantine on Cue-Induced Alcohol Craving in Recovering Alcohol-Dependent Patients

2007 • 111 citations

Effects of the mGlu2/3 Agonist LY379268 and the mGlu5 Antagonist MTEP on Ethanol Seeking and Reinforcement Are Differentially Altered in Rats with a History of Ethanol Dependence

2010 • 109 citations

Diffusion Tensor Imaging and Decision Making in Cocaine Dependence

2010 • 103 citations

Agonist‐like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies

2010 • 102 citations

A pilot study of impulsivity and compulsivity in pathological gambling

2009 • 101 citations

A Pilot Double‐Blind Treatment Trial of Memantine for Alcohol Dependence

2007 • 99 citations

Dopamine receptors in the learning, memory and drug reward circuitry

2009 • 99 citations

Pilot randomized controlled study of dexamphetamine substitution for amphetamine dependence

2001 • 93 citations

Long-term risk preference and suboptimal decision making following adolescent alcohol use

2009 • 93 citations

Impact of Psychosocial Adversity on Alcohol Intake in Young Adults: Moderation by the LL Genotype of the Serotonin Transporter Polymorphism

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White Matter Integrity is Associated with Treatment Outcome Measures in Cocaine Dependence

2010 • 86 citations

Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeys

2008 • 85 citations

A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms

2006 • 85 citations

Reduced neural response to reward following 7 days treatment with the cannabinoid CB1 antagonist rimonabant in healthy volunteers

2010 • 85 citations

Pharmacological Stimulation of Group II Metabotropic Glutamate Receptors Reduces Cocaine Self-Administration and Cocaine-Induced Reinstatement of Drug Seeking in Squirrel Monkeys

2006 • 84 citations

Atomoxetine and Stroop Task Performance in Adult Attention-Deficit/Hyperactivity Disorder

2005 • 84 citations

Repeated Lofexidine Treatment Attenuates Stress-Induced, But not Drug Cues-Induced Reinstatement of a Heroin-Cocaine Mixture (Speedball) Seeking in Rats

2001 • 83 citations

Control Yourself: Alcohol and Impulsivity

2010 • 83 citations

Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction

2010 • 79 citations

Substance Abuse Vaccines

2008 • 76 citations

Effect of Bupropion Treatment on Brain Activation Induced by Cigarette-Related Cues in Smokers

2011 • 76 citations

Diffusion tensor imaging eigenvalues: Preliminary evidence for altered myelin in cocaine dependence

2007 • 73 citations

Serotonin 1B Receptor Imaging in Alcohol Dependence

2010 • 72 citations

Effects of Opioid Receptor Gene Variation on Targeted Nalmefene Treatment in Heavy Drinkers

2008 • 70 citations

Selective Norepinephrine Reuptake Inhibition by Atomoxetine Prevents Cue-Induced Heroin and Cocaine Seeking

2010 • 63 citations

Effects of Two Novel D₃-Selective Compounds, NGB 2904 [N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rhesus Monkeys

2007 • 62 citations

Differences in orbitofrontal activation during decision-making between methadone-maintained opiate users, heroin users and healthy volunteers

2006 • 61 citations

What Is Addiction?

2010 • 60 citations

Neurobiology of Adolescent Substance Use Disorders: Implications for Prevention and Treatment

2010 • 60 citations

A scale-free systems theory of motivation and addiction

2007 • 58 citations

Drug Abuse: Vulnerability and Transition to Addiction

2009 • 56 citations

Modafinil: A Useful Medication for Cocaine Addiction? Review of the Evidence from Neuropharmacological, Experimental and Clinical Studies

2008 • 55 citations

Current status of immunologic approaches to treating tobacco dependence: Vaccines and nicotine-specific antibodies

2006 • 55 citations

Choosing a behavioral therapy platform for pharmacotherapy of substance users

2004 • 55 citations

Cognitive enhancement therapy for schizophrenia

2004 • 53 citations

Dopamine D3 and D2 Receptor Mechanisms in the Abuse-Related Behavioral Effects of Cocaine: Studies with Preferential Antagonists in Squirrel Monkeys

2010 • 52 citations

A placebo-controlled trial of memantine for cocaine dependence with high-value voucher incentives during a pre-randomization lead-in period

2010 • 50 citations

Internal validity of project MATCH treatments: Discriminability and integrity.

1998 • 44 citations

Effects of atomoxetine and methylphenidate on performance of a lateralized reaction time task in rats

2008 • 43 citations

The Treatment of Obesity and Its Co-Occurrence With Substance Use Disorders

2010 • 43 citations

The neurobiology, clinical efficacy and safety of acamprosate in the treatment of alcohol dependence

2009 • 42 citations

The effect of 12-week open-label memantine treatment on cognitive function improvement in patients with alcohol-related dementia

2008 • 40 citations

Galantamine improves sustained attention in chronic cocaine users.

2011 • 40 citations

Can serotonin transporter genotype predict serotonergic function, chronicity, and severity of drinking?

2007 • 38 citations

The Treatment of Pathologic Gambling

2008 • 37 citations

Heterogeneity of Reward Mechanisms

2009 • 31 citations

Addiction Genetics and Pleiotropic Effects of Common Haplotypes that Make Polygenic Contributions to Vulnerability to Substance Dependence

2009 • 30 citations

Varenicline attenuates some of the subjective and physiological effects of intravenous nicotine in humans

2009 • 29 citations

Effects of Naltrexone During the Descending Limb of the Blood Alcohol Curve

2008 • 29 citations

Impulse Control Disorders and Co-Occurring Disorders: Dual Diagnosis Considerations

2007 • 28 citations

Pathological Gambling: Etiology, Comorbidity, and Treatment

2006 • 26 citations

Effects of Treatment for Tobacco Dependence on Resting Cerebral Glucose Metabolism

2009 • 22 citations

Improving treatment response of cognitively impaired veterans with neuropsychological rehabilitation.

2006 • 21 citations

Don't! The secret of self-control.

2009 • 20 citations

Introduction

2007 • 20 citations

Gambling: Mapping the American Moral Landscape

2009 • 19 citations

Deleted Work

1955 • 0 citations