Activation of Group II Metabotropic Glutamate Receptors Attenuates Both Stress and Cue-Induced Ethanol-Seeking and Modulates c-fosExpression in the Hippocampus and Amygdala

Précis ofThe neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system

1982 • 4,511 citations

The reinstatement model of drug relapse: history, methodology and major findings

2002 • 1,586 citations

Pattern and time course of immediate early gene expression in rat brain following acute stress

1995 • 1,032 citations

Conditioning factors in drug abuse: can they explain compulsion?

1998 • 680 citations

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

2001 • 678 citations

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

2005 • 593 citations

Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat

1993 • 554 citations

Limbic and Motor Circuitry Underlying Footshock-Induced Reinstatement of Cocaine-Seeking Behavior

2004 • 518 citations

The Role of the Dorsomedial Prefrontal Cortex, Basolateral Amygdala, and Dorsal Hippocampus in Contextual Reinstatement of Cocaine Seeking in Rats

2004 • 518 citations

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study

1993 • 518 citations

Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior

2005 • 507 citations

Psychological stress, drug-related cues and cocaine craving

2000 • 451 citations

Fos Protein Expression and Cocaine-Seeking Behavior in Rats after Exposure to a Cocaine Self-Administration Environment

2000 • 437 citations

Neurobiology of craving, conditioned reward and relapse

2004 • 397 citations

Hippocampus and context in classical conditioning

1999 • 379 citations

Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states

2003 • 359 citations

Neuroendocrine responses to an emotional stressor: evidence for involvement of the medial but not the central amygdala

1999 • 304 citations

The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats.

1999 • 266 citations

Neural substrates of conditioned-cued relapse to drug-seeking behavior

2002 • 259 citations

A Role of Ventral Tegmental Area Glutamate in Contextual Cue-Induced Relapse to Heroin Seeking

2004 • 244 citations

Preferential Effects of the Metabotropic Glutamate 2/3 Receptor Agonist LY379268 on Conditioned Reinstatement versus Primary Reinforcement: Comparison between Cocaine and a Potent Conventional Reinforcer

2004 • 236 citations

The ups and downs of addiction: role of metabotropic glutamate receptors

2004 • 220 citations

Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and drug-related cues

2005 • 164 citations

Effects of environmental and pharmacological stressors on c-fos and corticotropin-releasing factor mRNA in rat brain: Relationship to the reinstatement of alcohol seeking

2005 • 138 citations

Suppression of alcohol self-administration and cue-induced reinstatement of alcohol seeking by the mGlu2/3 receptor agonist LY379268 and the mGlu8 receptor agonist (S)-3,4-DCPG

2005 • 137 citations

Expression of Fos‐related antigens in the nucleus accumbens and associated regions following exposure to a cocaine‐paired environment

2000 • 127 citations

Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine

2000 • 116 citations

Anxiolytic Activity of the MGLU2/3 Receptor Agonist LY354740 on the Elevated Plus Maze is Associated with the Suppression of Stress-Induced c-Fos in the Hippocampus and Increases in c-Fos Induction in Several Other Stress-Sensitive Brain Regions

2003 • 103 citations

Alcohol selectively attenuates stress-induced c-fos expression in rat hippocampus

1995 • 98 citations

Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists, LY354740 and DCG-IV

1998 • 97 citations

The antianxiety-like effects of antagonists of group I and agonists of group II and III metabotropic glutamate receptors after intrahippocampal administration

2001 • 93 citations

Possible neural substrates of beer-craving in rats

1998 • 91 citations

The novel mGluR2/3 agonist LY379268 attenuates cue-induced reinstatement of heroin seeking

2005 • 90 citations

Indomethacin Attenuates Oxytocin and Hypothalamic‐Pituitary‐Adrenal Axis Responses to Systemic Interleukin‐1β

1998 • 76 citations

Expression of fos protein in various rat brain areas following acute nicotine and diazepam

1996 • 68 citations

Mecamylamine and Ethanol Preference in Healthy Volunteers

2005 • 66 citations

Differential regulation of synaptic transmission by mGlu2 and mGlu3 at the perforant path inputs to the dentate gyrus and CA1 revealed in mGlu2 -/- mice

2002 • 58 citations

Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats.

2002 • 49 citations

Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats.

2002 • 47 citations

Neural Activation Profile Elicited by Cues Associated with the Anxiogenic Drug Yohimbine Differs from That Observed for Reward-Paired Cues

2002 • 43 citations

Immediate-early gene expression in the central nucleus of the amygdala is not specific for anxiolytic or anxiogenic drugs

2005 • 22 citations

Conditioned Taste Aversion Induced by Ethanol in Alcohol-Preferring Rats

1999 • 21 citations