Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor.

Organization of Ovine Corticotropin-Releasing Factor Immunoreactive Cells and Fibers in the Rat Brain: An Immunohistochemical Study

1983 • 1,954 citations

The reinstatement model of drug relapse: history, methodology and major findings

2002 • 1,586 citations

Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?

1990 • 1,362 citations

Addiction and the Brain Antireward System

2007 • 1,317 citations

CRF and CRF Receptors: Role in Stress Responsivity and Other Behaviors

2004 • 1,235 citations

Addiction, a Disease of Compulsion and Drive: Involvement of the Orbitofrontal Cortex

2000 • 1,224 citations

A Role for Brain Stress Systems in Addiction

2008 • 986 citations

Plasticity of reward neurocircuitry and the 'dark side' of drug addiction

2005 • 940 citations

Stress, Dysregulation of Drug Reward Pathways, and the Transition to Drug Dependence

2007 • 853 citations

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

2000 • 698 citations

Intermittent Access to 20% Ethanol Induces High Ethanol Consumption in Long–Evans and Wistar Rats

2008 • 589 citations

Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis

1995 • 568 citations

Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide

1996 • 561 citations

A role for corticotropin releasing factor and urocortin in behavioral responses to stressors

1999 • 527 citations

Activation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal

1997 • 494 citations

Psychological stress, drug-related cues and cocaine craving

2000 • 451 citations

Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men.

1997 • 430 citations

Compulsive Drug‐Seeking Behavior and Relapse

2001 • 412 citations

Alteration of ethanol self-administration by naltrexone

1980 • 402 citations

Corticotropin-Releasing Factor within the Central Nucleus of the Amygdala Mediates Enhanced Ethanol Self-Administration in Withdrawn, Ethanol-Dependent Rats

2006 • 378 citations

Cocaine Experience Establishes Control of Midbrain Glutamate and Dopamine by Corticotropin-Releasing Factor: A Role in Stress-Induced Relapse to Drug Seeking

2005 • 369 citations

Central CRH system in depression and anxiety — Evidence from clinical studies with CRH1 receptor antagonists

2008 • 368 citations

Additive Effect of Stress and Drug Cues on Reinstatement of Ethanol Seeking: Exacerbation by History of Dependence and Role of Concurrent Activation of Corticotropin-Releasing Factor and Opioid Mechanisms

2002 • 357 citations

Corticotropin-Releasing Factor in Brain: A Role in Activation, Arousal, and Affect Regulation

2004 • 352 citations

The Role of Corticotropin-Releasing Factor and Corticosterone in Stress- and Cocaine-Induced Relapse to Cocaine Seeking in Rats

1998 • 326 citations

Corticotropin Releasing Factor–Induced Amygdala Gamma-Aminobutyric Acid Release Plays a Key Role in Alcohol Dependence

2010 • 323 citations

Corticotropin-releasing factor and neuropeptide y: role in emotional integration

1994 • 320 citations

Upregulation of Voluntary Alcohol Intake, Behavioral Sensitivity to Stress, and Amygdala Crhr1 Expression Following a History of Dependence

2007 • 315 citations

The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats

2000 • 314 citations

Corticotropin-Releasing Factor, But Not Corticosterone, Is Involved in Stress-Induced Relapse to Heroin-Seeking in Rats

1997 • 308 citations

CP-154,526, a selective, non-peptide antagonist of the corticotropin-releasing factor 1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroin-trained rats

1998 • 298 citations

Corticotropin-Releasing Factor Requires CRF Binding Protein to Potentiate NMDA Receptors via CRF Receptor 2 in Dopamine Neurons

2003 • 297 citations

Piecing together the Puzzle of Basal Forebrain Anatomy

1991 • 286 citations

Corticotropin-Releasing Factor 1 Antagonists Selectively Reduce Ethanol Self-Administration in Ethanol-Dependent Rats

2006 • 276 citations

Effect of environmental stressors on opiate and psychostimulant reinforcement, reinstatement and discrimination in rats: a review

2003 • 272 citations

Brain corticotropin-releasing factor mediates ‘anxiety-like’ behavior induced by cocaine withdrawal in rats

1995 • 256 citations

Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress

2006 • 250 citations

Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats

2001 • 249 citations

A 6-Week Randomized, Placebo-Controlled Trial of CP-316,311 (a Selective CRH ₁ Antagonist) in the Treatment of Major Depression

2008 • 245 citations

3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism

2007 • 242 citations

CRF–CRF ₁ system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats

2007 • 241 citations

Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: Ancient CRF paralogs

2006 • 240 citations

Elevated extracellular CRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intake

2002 • 239 citations

Corticotropin Releasing Factor (CRF) Binding Protein: A Novel Regulator of CRF and Related Peptides

1995 • 239 citations

Interaction between CRHR1 Gene and Stressful Life Events Predicts Adolescent Heavy Alcohol Use

2007 • 209 citations

In vivo CRF release in rat amygdala is increased during cocaine withdrawal in self-administering rats

1999 • 208 citations

Stress-induced relapse to cocaine seeking: roles for the CRF2 receptor and CRF-binding protein in the ventral tegmental area of the rat

2007 • 208 citations

Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats

1999 • 190 citations

The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats

2007 • 188 citations

Can induced moods trigger drug-related responses in opiate abuse patients?

1994 • 180 citations

Characterization of a novel and potent corticotropin-releasing factor antagonist in rats.

1994 • 178 citations

The therapeutic potential of CRF1 antagonists for anxiety

2004 • 173 citations

Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors

2003 • 169 citations

Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout

2007 • 163 citations

The Anxiogenic Drug Yohimbine Reinstates Palatable Food Seeking in a Rat Relapse Model: a Role of CRF1 Receptors

2005 • 154 citations

Replication and extension of Marlatt's taxonomy of relapse precipitants: overview of procedures and results

1996 • 153 citations

Role of corticotropin-releasing factor (CRF) receptors in the anorexic syndrome induced by CRF.

2000 • 143 citations

Anti-Stress Action of a Corticotropin-Releasing Factor Antagonist on Behavioral Reactivity to Stressors of Varying Type and Intensity

1994 • 142 citations

Alcohol withdrawal symptoms and drinking behavior.

1977 • 140 citations

Buprenorphine and a CRF1 Antagonist Block the Acquisition of Opiate Withdrawal-Induced Conditioned Place Aversion in Rats

2004 • 138 citations

Antagonism of CRF2 receptors produces anxiolytic behavior in animal models of anxiety

2001 • 133 citations

Increased Anxiety‐Like Behavior and Ethanol Self‐Administration in Dependent Rats: Reversal via Corticotropin‐Releasing Factor‐2 Receptor Activation

2004 • 132 citations

SB242084, flumazenil, and CRA1000 block ethanol withdrawal–induced anxiety in rats

2004 • 130 citations

Behavioral and neural mechanisms of compulsive drug seeking

2005 • 130 citations

Corticotropin-Releasing Factor-1 Receptor Activation Mediates Nicotine Withdrawal-Induced Deficit in Brain Reward Function and Stress-Induced Relapse

2009 • 129 citations

Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression

2003 • 126 citations

CRF1 receptor antagonists attenuate escalated cocaine self-administration in rats

2007 • 125 citations

The Effects of Acamprosate and Neramexane on Cue-Induced Reinstatement of Ethanol-Seeking Behavior in Rat

2005 • 121 citations

Relapse research and the Reasons for Drinking Questionnaire: a factor analysis of Marlatt's relapse taxonomy

1996 • 120 citations

The role of corticotropin-releasing factor-like peptides in cannabis, nicotine, and alcohol dependence

2005 • 117 citations

Effects of Naltrexone Alone and In Combination With Acamprosate on the Alcohol Deprivation Effect in Rats

2003 • 108 citations

Synapses between corticotropin‐releasing factor‐containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic

2007 • 108 citations

Effects of CRF₁‐Receptor and Opioid‐Receptor Antagonists on Dependence‐Induced Increases in Alcohol Drinking by Alcohol‐Preferring (P) Rats

2008 • 108 citations

Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats

2006 • 105 citations

Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats

2008 • 102 citations

Antagonism of CRF Receptors Prevents the Deficit in Brain Reward Function Associated with Precipitated Nicotine Withdrawal in Rats

2006 • 102 citations

The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal

2005 • 101 citations

Dose-dependent suppression of the high alcohol intake of chronically intoxicated rats by Ca-acetyl homotaurinate

1987 • 97 citations

MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist

2007 • 93 citations

Interaction between noradrenaline and corticotrophin-releasing factor in the reinstatement of cocaine seeking in the rat

2008 • 89 citations

PRECLINICAL STUDY: Corticotropin‐releasing factor‐1 receptor antagonists decrease heroin self‐administration in long‐ but not short‐access rats

2009 • 86 citations

PRECLINICAL STUDY: Region‐specific down‐regulation of Crhr1 gene expression in alcohol‐preferring msP rats following ad lib access to alcohol

2007 • 82 citations

Chronic Cocaine Enhances Corticotropin-Releasing Factor-Dependent Potentiation of Excitatory Transmission in Ventral Tegmental Area Dopamine Neurons

2009 • 82 citations

Subtype-Selective Corticotropin-Releasing Factor Receptor Agonists Exert Contrasting, but Not Opposite, Effects on Anxiety-Related Behavior in Rats

2007 • 81 citations

Attenuation of fear conditioning by antisense inhibition of brain corticotropin releasing factor-2 receptor

2001 • 78 citations

Studies on duration of a late recovery period after chronic abuse of ethanol

1982 • 75 citations

Behavioral Effects of Central Administration of The Novel CRF Antagonist Astressin in Rats

2000 • 73 citations

Gender in relation to relapse crisis situations, coping, and outcome among treated alcoholics

1998 • 72 citations

CRH Haplotype as a Factor Influencing Cerebrospinal Fluid Levels of Corticotropin-Releasing Hormone, Hypothalamic-Pituitary-Adrenal Axis Activity, Temperament, and Alcohol Consumption in Rhesus Macaques

2008 • 63 citations

Corticotropin-Releasing Factor Receptor Antagonists in Affective Disorders and Drug Dependence - An Update

2006 • 48 citations

Corticotropin releasing factor antagonist, α-helical CRF9–41, reverses nicotine-induced conditioned, but not unconditioned, anxiety

2003 • 38 citations

Corticotropin-Releasing Hormone (CRH) mRNA Expression in Rat Central Amygdala in Cannabinoid Tolerance and Withdrawal: Evidence for an Allostatic Shift?

2003 • 36 citations

The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal

2007 • 30 citations

Addiction and the Brain Antireward System

2008 • 28 citations