Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Live or let die: the cell's response to p53

2002 • 3,138 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

A DNA damage checkpoint response in telomere-initiated senescence

2003 • 2,600 citations

Mammalian Telomeres End in a Large Duplex Loop

1999 • 2,372 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

Switching and Signaling at the Telomere

2001 • 2,073 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

TRF2 Protects Human Telomeres from End-to-End Fusions

1998 • 1,679 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

Telomere states and cell fates

2000 • 1,359 citations

DNA Damage Foci at Dysfunctional Telomeres

2003 • 1,341 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

Essential role of mouse telomerase in highly proliferative organs

1998 • 1,256 citations

Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

2004 • 1,246 citations

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

2000 • 1,077 citations

p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

1999 • 1,076 citations

Post‐translational modifications and activation of p53 by genotoxic stresses

2001 • 1,076 citations

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1998 • 1,001 citations

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

1999 • 969 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Chromosome aberrations in solid tumors

2003 • 805 citations

Bypass of Senescence After Disruption of p21 ^CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

1997 • 797 citations

Regulation of Telomerase by Telomeric Proteins

2004 • 788 citations

A role for both RB and p53 in the regulation of human cellular senescence*1

1991 • 737 citations

POT1 as a terminal transducer of TRF1 telomere length control

2003 • 681 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

1999 • 663 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

Identification of Human Rap1

2000 • 559 citations

Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

1984 • 550 citations

Plasma antioxidants from chocolate

2003 • 535 citations

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

2001 • 525 citations

TIN2, a new regulator of telomere length in human cells

1999 • 523 citations

Dissecting p53 tumor suppressor functions in vivo

2002 • 491 citations

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

1999 • 462 citations

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

2004 • 451 citations

PTOP interacts with POT1 and regulates its localization to telomeres

2004 • 440 citations

Telosome, a Mammalian Telomere-associated Complex Formed by Multiple Telomeric Proteins

2004 • 392 citations

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

2003 • 374 citations

Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse

1999 • 373 citations

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis

2000 • 346 citations

TIN2 Binds TRF1 and TRF2 Simultaneously and Stabilizes the TRF2 Complex on Telomeres

2004 • 343 citations

Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein

1999 • 338 citations

Accelerated telomere shortening in ataxia telangiectasia

1996 • 334 citations

Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice

1999 • 322 citations

Telomere Length Abnormalities Occur Early in the Initiation of Epithelial Carcinogenesis

2004 • 310 citations

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

2003 • 307 citations

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

2000 • 304 citations

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

1996 • 299 citations

PML Is a Direct p53 Target that Modulates p53 Effector Functions

2004 • 298 citations

Telomere dysfunction provokes regional amplification and deletion in cancer genomes

2002 • 240 citations

TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex

2004 • 187 citations

DNA damage checkpoint kinase Chk2 triggers replicative senescence

2004 • 187 citations

Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.

2003 • 65 citations

Recent advances in telomere biology: implications for human cancer

2003 • 55 citations

Perp-etrating p53-Dependent Apoptosis

2004 • 47 citations

Executing Cell Senescence

2004 • 28 citations

DNA-binding Properties of the p53 Tumor Suppressor Protein

1994 • 17 citations