A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

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1999 • 1,154 citations

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1994 • 865 citations

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data

2005 • 758 citations

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics

1982 • 629 citations

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

1997 • 460 citations

Annual Review of Pharmacology,

1975 • 388 citations

The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

2002 • 378 citations

Is the role of the small intestine in first-pass metabolism overemphasized?

1999 • 344 citations

EVALUATION OF DRUG-DRUG INTERACTION IN THE HEPATOBILIARY AND RENAL TRANSPORT OF DRUGS

2004 • 333 citations

Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.

2001 • 309 citations

Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices

1997 • 298 citations

Cryopreserved human hepatocytes: characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug–drug interaction potential

1999 • 295 citations

EVALUATION OF FRESH AND CRYOPRESERVED HEPATOCYTES AS IN VITRO DRUG METABOLISM TOOLS FOR THE PREDICTION OF METABOLIC CLEARANCE

2004 • 264 citations

Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes

2004 • 219 citations

Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection

2003 • 197 citations

Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

2003 • 183 citations

Integration of in Vitro Data into Allometric Scaling to Predict Hepatic Metabolic Clearance in Man: Application to 10 Extensively Metabolized Drugs

1997 • 177 citations

Prediction of Hepatic Clearance and Availability by Cryopreserved Human Hepatocytes: An Application of Serum Incubation Method

2002 • 163 citations

THE BINDING OF DRUGS TO HEPATOCYTES AND ITS RELATIONSHIP TO PHYSICOCHEMICAL PROPERTIES

2004 • 160 citations

Development of a Novel in Vitro Model to Predict Hepatic Clearance Using Fresh, Cryopreserved, and Sandwich-Cultured Hepatocytes

2002 • 129 citations

Function of Uptake Transporters for Taurocholate and Estradiol 17β-D-Glucuronide in Cryopreserved Human Hepatocytes

2003 • 116 citations

Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

1999 • 115 citations

The use of human hepatocytes to select compounds based on their expected hepatic extraction ratios in humans.

1997 • 106 citations

Predictive ADMET studies, the challenges and the opportunities

2004 • 99 citations

THE ROLES OF TRANSPORTERS AND ENZYMES IN HEPATIC DRUG PROCESSING

2004 • 93 citations

A comprehensive analysis of the role of correction factors in the allometric predictivity of clearance from rat, dog, and monkey to humans

2004 • 90 citations

Progress Towards Prediction of Human Pharmacokinetic Parameters from In Vitro Technologies

2003 • 83 citations

Combining in Vitro and in Vivo Pharmacokinetic Data for Prediction of Hepatic Drug Clearance in Humans by Artificial Neural Networks and Multivariate Statistical Techniques

1999 • 76 citations

AN EVALUATION OF THE IN VITRO METABOLISM DATA FOR PREDICTING THE CLEARANCE AND DRUG-DRUG INTERACTION POTENTIAL OF CYP2C9 SUBSTRATES

2004 • 69 citations

Comparison of clearance predictions using primary cultures and suspensions of human hepatocytes

2005 • 46 citations

Cellular models for ADMET predictions and evaluation of drug-drug interactions.

2004 • 35 citations