Involvement of Multiple Efflux Transporters in Hepatic Disposition of Fexofenadine

MRP3, an organic anion transporter able to transport anti-cancer drugs

1999 • 639 citations

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.

1999 • 585 citations

The MRP4/ABCC4 Gene Encodes a Novel Apical Organic Anion Transporter in Human Kidney Proximal Tubules

2002 • 498 citations

Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

1999 • 496 citations

Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy

2004 • 407 citations

Characterization of the Transport of Nucleoside Analog Drugs by the Human Multidrug Resistance Proteins MRP4 and MRP5

2003 • 368 citations

Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane

2003 • 349 citations

Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3)

1999 • 349 citations

ABCG2 Transports Sulfated Conjugates of Steroids and Xenobiotics

2003 • 336 citations

ATP-dependent Transport of Bile Salts by Rat Multidrug Resistance-associated Protein 3 (Mrp3)

2000 • 333 citations

The human bile salt export pump: Characterization of substrate specificity and identification of inhibitors

2002 • 328 citations

Multidrug resistance-associated proteins 3, 4, and 5

2006 • 290 citations

Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.

1998 • 265 citations

Characterization of Drug Transport by the Human Multidrug Resistance Protein 3 (ABCC3)

2001 • 255 citations

Involvement of BCRP (ABCG2) in the Biliary Excretion of Pitavastatin

2005 • 253 citations

Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.

2001 • 249 citations

Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis†

2005 • 242 citations

The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

2003 • 234 citations

The Breast Cancer Resistance Protein (BCRP/ABCG2) Affects Pharmacokinetics, Hepatobiliary Excretion, and Milk Secretion of the Antibiotic Nitrofurantoin

2005 • 220 citations

Identification of the Hepatic Efflux Transporters of Organic Anions Using Double-Transfected Madin-Darby Canine Kidney II Cells Expressing Human Organic Anion-Transporting Polypeptide 1B1 (OATP1B1)/Multidrug Resistance-Associated Protein 2, OATP1B1/Multidrug Resistance 1, and OATP1B1/Breast Cancer Resistance Protein

2005 • 192 citations

CONTRIBUTION OF OATP (ORGANIC ANION-TRANSPORTING POLYPEPTIDE) FAMILY TRANSPORTERS TO THE HEPATIC UPTAKE OF FEXOFENADINE IN HUMANS

2005 • 180 citations

Mrp4−/− mice have an impaired cytoprotective response in obstructive cholestasis

2006 • 175 citations

Bile Salt Export Pump (BSEP/ABCB11) Can Transport a Nonbile Acid Substrate, Pravastatin

2005 • 174 citations

Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides

2005 • 174 citations

Excretion of GSSG and Glutathione Conjugates Mediated by MRP1 and CM0AT/MRP2

1998 • 159 citations

Carcinogen and Anticancer Drug Transport by Mrp2 in Vivo: Studies UsingMrp2(Abcc2) Knockout Mice

2006 • 152 citations

Characterization of Mice Lacking the Multidrug Resistance Protein Mrp2 (Abcc2)

2006 • 141 citations

The ABC Transporters MDR1 and MRP2: Multiple Functions in Disposition of Xenobiotics and Drug Resistance

2004 • 135 citations

Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein.

2000 • 124 citations

Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3.

2002 • 123 citations

Genetic defects in hepatobiliary transport

2002 • 122 citations

P-GLYCOPROTEIN PLAYS A MAJOR ROLE IN THE EFFLUX OF FEXOFENADINE IN THE SMALL INTESTINE AND BLOOD-BRAIN BARRIER, BUT ONLY A LIMITED ROLE IN ITS BILIARY EXCRETION

2005 • 114 citations

Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11

2005 • 113 citations

Altered disposition of acetaminophen in mice with a disruption of theMrp3 gene

2005 • 103 citations

Investigation of the Inhibitory Effects of Various Drugs on the Hepatic Uptake of Fexofenadine in Humans

2008 • 88 citations

Establishment of a Set of Double Transfectants Coexpressing Organic Anion Transporting Polypeptide 1B3 and Hepatic Efflux Transporters for the Characterization of the Hepatobiliary Transport of Telmisartan Acylglucuronide

2008 • 80 citations

Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells.

1999 • 69 citations

Primary active transport of organic anions on bile canalicular membrane in humans

1999 • 60 citations

Multidrug Resistance-Associated Protein 2 Is Primarily Responsible for the Biliary Excretion of Fexofenadine in Mice

2007 • 48 citations

Bilirubin diglucuronide transport by rat liver canalicular membrane vesicles: Stimulation by bicarbonate ion

1991 • 25 citations

Bilirubin diglucuronide transport by rat liver canalicular membrane vesicles: Stimulation by bicarbonate ion,

1991 • 2 citations