Prediction of Pharmacokinetics Prior to In Vivo Studies. II. Generic Physiologically Based Pharmacokinetic Models of Drug Disposition

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

1999 • 1,154 citations

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1994 • 865 citations

Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism‐Based Prediction of Volume of Distribution

2002 • 527 citations

A Priori Prediction of Tissue:Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically‐Based Pharmacokinetic Models in Drug Discovery

2000 • 399 citations

Prediction of adipose tissue: Plasma partition coefficients for structurally unrelated drugs

2001 • 206 citations

In vitro andin vivo evaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic models

1982 • 147 citations

Determinants of benzodiazepine brain uptake: lipophilicity versus binding affinity

1987 • 121 citations

Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam.

1997 • 121 citations

Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model

1983 • 106 citations

Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtainedin vitro as well as on physiological data

1982 • 93 citations

Studies on the uptake and binding of propranolol by rat tissues.

1977 • 92 citations

Quantitative structure-pharmacokinetics relationships: I. Development of a whole-body physiologically based model to characterize changes in pharmacokinetics across a homologous series of barbiturates in the rat.

1997 • 83 citations

Combining in Vitro and in Vivo Pharmacokinetic Data for Prediction of Hepatic Drug Clearance in Humans by Artificial Neural Networks and Multivariate Statistical Techniques

1999 • 76 citations

Correlation betweenin vitro andin vivo drug metabolism rate: Oxidation of ethoxybenzamide in rat

1978 • 53 citations

Prediction of Drug Distribution in Distribution Dialysis and In Vivo from Binding to Tissues and Blood

1993 • 44 citations

Physiologically based pharmacokinetics model of primidone and its metabolites phenobarbital and phenylethylmalonamide in humans, rats, and mice.

1998 • 42 citations

An Approach for Incorporating Tissue Composition Data Into Physiologically Based Pharmacokinetic Models

1995 • 28 citations

Mechanistic Animal-Replacement Approaches for Predicting Pharmacokinetics of Organic Chemicals

1999 • 21 citations

Uptake of Basic Drugs into Rat Lung Granule Fraction in Vitro.

1998 • 20 citations

Propranolol Disposition in the Rat: Variation in Hepatic Extraction with Unbound Drug Fraction

1992 • 17 citations

Second peak of plasma diazepam concentration and enterogastric circulation.

1993 • 17 citations

Determination of in vivo hepatic extraction ratio from in vitro metabolism by rat hepatocytes.

1991 • 13 citations

Research to develop a predicting system of mammalian subacute toxicity (3) construction of a predictive toxicokinetics model

1996 • 8 citations

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