Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells

Toll-like receptor signalling

2004 • 7,983 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

2004 • 3,766 citations

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

2004 • 3,325 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens

2001 • 1,989 citations

Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2

2006 • 1,544 citations

TNF/iNOS-Producing Dendritic Cells Mediate Innate Immune Defense against Bacterial Infection

2003 • 1,129 citations

Recognition of pathogen-associated molecular patterns by TLR family

2003 • 1,124 citations

TRAIL and apoptosis induction by TNF-family death receptors

2003 • 843 citations

Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells

2001 • 792 citations

Toll-Like Receptor 8-Mediated Reversal of CD4 ⁺ Regulatory T Cell Function

2005 • 734 citations

TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

1997 • 683 citations

Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

1999 • 477 citations

Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)

2005 • 446 citations

Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail)

1999 • 408 citations

A novel dendritic cell subset involved in tumor immunosurveillance

2006 • 407 citations

Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity.

1996 • 401 citations

Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity

2006 • 393 citations

Antiviral response by natural killer cells throughTRAIL gene induction by IFN-α/β

2001 • 262 citations

Tumor-Selective Induction of Apoptosis and the Small-Molecule Immune Response Modifier Imiquimod

2003 • 258 citations

Virus or TLR Agonists Induce TRAIL-Mediated Cytotoxic Activity of Plasmacytoid Dendritic Cells

2006 • 247 citations

Subtractive hybridization reveals the expression of immunoglobulinlike transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells

2002 • 243 citations

Mechanisms of Interferon-alpha induced apoptosis in malignant cells

2002 • 218 citations

Identification and Characterization of pDC-Like Cells in Normal Mouse Skin and Melanomas Treated with Imiquimod

2004 • 205 citations

Disease-Independent Skin Recruitment and Activation of Plasmacytoid Predendritic Cells Following Imiquimod Treatment

2005 • 176 citations

Inhibition of murine tumor growth by an interferon-inducing imidazoquinolinamine.

1992 • 174 citations

Dosing With 5% Imiquimod Cream 3 Times per Week for the Treatment of Actinic Keratosis

2005 • 163 citations

The Small Antitumoral Immune Response Modifier Imiquimod Interacts with Adenosine Receptor Signaling in a TLR7- and TLR8-Independent Fashion

2006 • 158 citations

Innate Direct Anticancer Effector Function of Human Immature Dendritic Cells. II. Role of TNF, Lymphotoxin-α1β2, Fas Ligand, and TNF-Related Apoptosis-Inducing Ligand

2002 • 131 citations

Time-resolved fluorometric assay for natural killer activity using target cells labelled with a fluorescence enhancing ligand

1996 • 115 citations

Recruitment of dendritic cells in oral lichen planus

2005 • 113 citations

Microencapsulated iNOS‐expressing cells cause tumor suppression in mice

2001 • 109 citations

Induction of Interferon and Other Cytokines by Imiquimod and Its Hydroxylated Metabolite R-842 in Human Blood Cells In Vitro

1994 • 105 citations

A pilot study of treatment of lentigo maligna with 5% imiquimod cream

2004 • 102 citations

Innate Direct Anticancer Effector Function of Human Immature Dendritic Cells. I. Involvement of an Apoptosis-Inducing Pathway

2002 • 92 citations

Tumoricidal Potential of Native Blood Dendritic Cells: Direct Tumor Cell Killing and Activation of NK Cell-Mediated Cytotoxicity

2005 • 84 citations

Imiquimod as an antiangiogenic agent.

2005 • 81 citations

Recurrence rate of superficial basal cell carcinoma following successful treatment with imiquimod 5% cream: interim 2-year results from an ongoing 5-year follow-up study in Europe.

2005 • 76 citations

Effectiveness of imiquimod cream 5% for treating childhood molluscum contagiosum in a double-blind, randomized pilot trial.

2004 • 71 citations

Imiquimod Treatment of Superficial and Nodular Basal Cell Carcinoma: 12-Week Open-Label Trial

2006 • 69 citations

Imiquimod is a strong inhibitor of tumor cell‐induced angiogenesis

2004 • 68 citations

PI‐3K/Akt and NF‐κB/IκBα pathways are activated in Jurkat T cells in response to TRAIL treatment

2004 • 68 citations

Tumoricidal Activity of Monocyte-Derived Dendritic Cells: Evidence for a Caspase-8-Dependent, Fas-Associated Death Domain-Independent Mechanism

2001 • 64 citations

Immature CD4−CD103+ Rat Dendritic Cells Induce Rapid Caspase-Independent Apoptosis-Like Cell Death in Various Tumor and Nontumor Cells and Phagocytose Their Victims

2005 • 58 citations

Characterization of the cellular infiltrate during successful topical treatment of lentigo maligna with imiquimod

2004 • 58 citations

A Comparative Study of the Expression of Cytotoxic Proteins in Allergic Contact Dermatitis and Psoriasis

2001 • 53 citations

Imiquimod induced regression of clinically diagnosed superficial basal cell carcinoma is associated with early infiltration by CD4 T cells and dendritic cells

2004 • 51 citations

Dendritic Cells in Atopic Dermatitis: Expression of FcεRI on Two Distinct Inflammation-Associated Subsets

2005 • 48 citations

Long-term follow-up of basal cell carcinomas treated with perilesional interferon alfa 2b as monotherapy

2006 • 47 citations

An open-label phase II pilot study investigating the optimal duration of imiquimod 5% cream for the treatment of external genital warts in women

2006 • 44 citations

Evaluation of Superficial Basal Cell Carcinomas After Treatment With Imiquimod 5% Cream or Vehicle for Apoptosis and Lymphocyte Phenotyping

2003 • 43 citations

Topical imidazoquinoline therapy of cutaneous squamous cell carcinoma polarizes lymphoid and monocyte/macrophage populations to a Th1 and M1 cytokine pattern

2004 • 40 citations

Imiquimod Treatment of Superficial and Nodular Basal Cell Carcinoma

2005 • 35 citations

Interferon-alpha suppresses proliferation of chronic myelogenous leukemia cells K562 by extending cell cycle S-phase without inducing apoptosis

2003 • 26 citations

Increased TIA‐1 gene expression in the tumor microenvironment after locoregional administration of tumor necrosis factor‐α to patients with soft tissue limb sarcoma

2003 • 26 citations

PHOTODYNAMIC THERAPY AND IMIQUIMOD IMMUNOTHERAPY FOR BASAL CELL CARCINOMAS

2005 • 22 citations

Multiple superficial basal cell carcinomata--topical imiquimod versus curette and cryotherapy.

2005 • 10 citations