Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance

Innate Immune Recognition

2002 • 8,157 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

2002 • 1,529 citations

Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming

2004 • 1,284 citations

ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor

2001 • 1,190 citations

Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity

2001 • 1,036 citations

Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB

1999 • 1,006 citations

Regulation of Cutaneous Malignancy by γδ T Cells

2001 • 945 citations

Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells

2001 • 937 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages

2000 • 864 citations

Coordinated Induction by IL15 of a TCR-Independent NKG2D Signaling Pathway Converts CTL into Lymphokine-Activated Killer Cells in Celiac Disease

2004 • 809 citations

A Direct Role for NKG2D/MICA Interaction in Villous Atrophy during Celiac Disease

2004 • 724 citations

Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice

2000 • 694 citations

Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells

2003 • 639 citations

The Role of the NKG2D Immunoreceptor in Immune Cell Activation and Natural Killing

2002 • 634 citations

Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding

2002 • 624 citations

In vivo developmental stages in murine natural killer cell maturation

2002 • 588 citations

Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumorin vivo

2001 • 588 citations

Viral infection switches non-plasmacytoid dendritic cells into high interferon producers

2003 • 582 citations

Elevated TGF-β1 Secretion and Down-Modulation of NKG2D Underlies Impaired NK Cytotoxicity in Cancer Patients

2004 • 518 citations

Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia

2003 • 510 citations

Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity.

2002 • 509 citations

Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis

2003 • 501 citations

γδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity

2003 • 416 citations

Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex

1992 • 407 citations

NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma

2001 • 345 citations

Evasion from NK Cell Immunity by MHC Class I Chain-Related Molecules Expressing Colon Adenocarcinoma

2003 • 319 citations

NK Cells, MHC Class I Molecules and the Missing Self

2002 • 305 citations

NKG2D Blockade Prevents Autoimmune Diabetes in NOD Mice

2004 • 293 citations

Impairment of NK Cell Function by NKG2D Modulation in NOD Mice

2003 • 277 citations

Cutting Edge: Murine UL16-Binding Protein-Like Transcript 1: A Newly Described Transcript Encoding a High-Affinity Ligand for Murine NKG2D

2002 • 271 citations

Biological Insights into TCRγδ+ and TCRαβ+ Intraepithelial Lymphocytes Provided by Serial Analysis of Gene Expression (SAGE)

2001 • 267 citations

Binding ofEscherichia coliadhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA

2002 • 235 citations

Progression of Armed CTL from Draining Lymph Node to Spleen Shortly After Localized Infection with Herpes Simplex Virus 1

2002 • 231 citations

Toll-like receptors as potential therapeutic targets for multiple diseases

2002 • 229 citations

Natural Killer Cells in the Mouse: An Alternative Immune Surveillance Mechanism?

1978 • 205 citations

MICA and MICB genes: can the enigma of their polymorphism be resolved?

2001 • 194 citations

The Distinct Contributions of Murine T Cell Receptor (TCR)γδ+ and TCRαβ+ T Cells to Different Stages of Chemically Induced Skin Cancer

2003 • 169 citations

Expression of Stress-induced MHC Class I Related Chain Molecules on Human Melanoma

2002 • 168 citations

Tissue- and stratum-specific expression of the human involucrin promoter in transgenic mice.

1993 • 141 citations

Conservation of T Cell Receptor Conformation in Epidermal γδ Cells with Disrupted Primary V _γ Gene Usage

1998 • 117 citations

Dynamic response of murine gut intraepithelial T cells after infection by the coccidian parasite Eimeria

1993 • 79 citations

Examination of HY Response: T Cell Expansion, Immunodominance, and Cross-Priming Revealed by HY Tetramer Analysis

2001 • 73 citations

Broadly impaired NK cell function in non-obese diabetic mice is partially restored by NK cell activation in vivo and by IL-12/IL-18 in vitro

2003 • 52 citations

Characterizing the Protective Component of the αβ T Cell Response to Transplantable Squamous Cell Carcinoma

2004 • 37 citations

High Levels of RAE-1 Isoforms on Mouse Tumor Cell Lines Assessed by Anti-“pan” RAE-1 Antibody Confer Tumor Susceptibility to NK Cells

2002 • 25 citations