Oxygen Radicals and Human Disease

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1983 • 3,602 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

The aging process.

1981 • 1,871 citations

Cell Damage in the Brain: A Speculative Synthesis

1981 • 1,827 citations

Free-radical chemistry of cigarette smoke and its toxicological implications.

1985 • 1,351 citations

Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

1982 • 1,241 citations

Superoxide radicals in feline intestinal ischemia

1981 • 1,213 citations

The Reduction of Cytochrome c by Milk Xanthine Oxidase

1968 • 1,201 citations

Oxygen free radicals in ischemic acute renal failure in the rat.

1984 • 1,041 citations

The importance of free radicals and catalytic metal ions in human diseases

1985 • 939 citations

Iron withholding: a defense against infection and neoplasia.

1984 • 893 citations

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

1983 • 890 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Oxygen radicals and the nervous system

1985 • 822 citations

LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPY

1984 • 820 citations

Ischemic injury in the cat small intestine: Role of superoxide radicals

1982 • 771 citations

A new Salmonella tester strain (TA102) with A X T base pairs at the site of mutation detects oxidative mutagens.

1982 • 747 citations

Ischemia-reperfusion injury: role of oxygen-derived free radicals.

1986 • 680 citations

Xanthine oxidase as a source of free radical damage in myocardial ischemia

1985 • 678 citations

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1979 • 637 citations

Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides

1986 • 634 citations

Radioprotectors and anticarcinogens

1983 • 613 citations

Lipid peroxidation and cellular damage in toxic liver injury.

1985 • 556 citations

Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart

1980 • 550 citations

Uric acid-iron ion complexes. A new aspect of the antioxidant functions of uric acid

1986 • 538 citations

Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells.

1986 • 516 citations

The oxygen paradox and the calcium paradox: Two facets of the same problem?

1978 • 491 citations

Abrupt reoxygenation of the anoxic potassium-arrested perfused rat heart: A study of myocardial enzyme release

1973 • 443 citations

Chemistry of free radical and singlet oxidation of lipids

1984 • 442 citations

Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins.

1986 • 442 citations

The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme

1972 • 432 citations

The role of oxygen-derived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability.

1985 • 415 citations

George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury.

1985 • 393 citations

Allopurinol and oxypurinol are hydroxyl radical scavengers

1987 • 393 citations

Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species.

1980 • 385 citations

Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar.

1983 • 373 citations

Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage.

1984 • 365 citations

Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria

1983 • 360 citations

Cocarcinogenic and Tumor-Promoting Agents in Tobacco Carcinogenesis2

1976 • 344 citations

Free Radical Theory of Aging: Effect of Free Radical Reaction Inhibitors on the Mortality Rate of Male LAF1 Mice

1968 • 339 citations

Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron

1984 • 334 citations

OXIDANT ACTIVITY IN EXPIRED BREATH OF PATIENTS WITH ADULT RESPIRATORY DISTRESS SYNDROME

1986 • 330 citations

The measurement of free radical reactions in humans

1987 • 325 citations

The Role of Oxygen-derived Free Radicals in the Pathogenesis of Acute Pancreatitis

1984 • 299 citations

Spontaneous cancer and its possible relationship to oxygen metabolism.

1980 • 298 citations

The Role of Oxygen Radicals as a Possible Mechanism of Tumor Promotion

1985 • 282 citations

Antioxidants, Aging, and Longevity

1984 • 279 citations

Reactive oxygen species: production and role in the kidney

1986 • 267 citations

Canine cardiac calcium‐dependent proteases: Resolution of two forms with different requirements for calcium

1980 • 267 citations

Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer quinones.

1986 • 263 citations

Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine

1986 • 262 citations

Role of free radicals in ischemia-reperfusion injury to the liver.

1986 • 253 citations

Free radical theory of aging: Consequences of mitochondrial aging

1983 • 239 citations

HEPATIC AND RENAL EFFECTS OF PEROXISOME PROLIFERATORS: BIOLOGICAL IMPLICATIONS*

1982 • 237 citations

The oxygen free radical system: A fundamental mechanism in the production of myocardial necrosis

1986 • 236 citations

New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system.

1987 • 235 citations

ANTIOXIDANT PROTECTION: A FUNCTION OF TRACHEOBRONCHIAL AND GASTROINTESTINAL MUCUS

1984 • 231 citations

Formation of 8-hydroxyguanine moiety in deoxyribonucleic acid on .gamma.-irradiation in aqueous solution

1985 • 224 citations

Antioxidant properties of the proteins caeruloplasmin, albumin and transferrin. A study of their activity in serum and synovial fluid from patients with rheumatoid arthritis

1986 • 213 citations

Evidence for the role of oxygen radicals in acute nephrotoxic nephritis.

1984 • 212 citations

Myocardial consequences of reperfusion

1987 • 212 citations

The Toxicology of Molecular Oxygen

1984 • 210 citations

Cause of death in very old people.

1982 • 204 citations

Angiotoxicity of Oxygenated Sterols and Possible Precursors

1980 • 202 citations

Xanthine oxidase type D (dehydrogenase) in the intestine and other organs of the rat

1972 • 201 citations

Radiation-induced Decomposition of the Purine Bases within DNA and Related Model Compounds

1985 • 193 citations

Dimethyl sulfoxide prevents DNA nicking mediated by ionizing radiation or iron/hydrogen peroxide-generated hydroxyl radical.

1981 • 192 citations

Free radical theory of aging: The “free radical” diseases

1984 • 192 citations

The Inhibition of Lipid Autoxidation by Human Serum and its Relation to Serum Proteins and α-Tocopherol

1974 • 188 citations

Responses of the ischemic myocardium to allopurinol

1971 • 183 citations

Cerebral and Ocular Toxicity Induced by Desferrioxamine

1985 • 179 citations

Aspects to Consider When Detecting and Measuring Lipid Peroxidation

1986 • 172 citations

Enzyme action at 3' termini of ionizing radiation-induced DNA strand breaks.

1983 • 171 citations

Smoke composition. An extensive investigation of the water-soluble portion of cigarette smoke

1977 • 170 citations

Cytotoxicity from Coupled Redox Cycling of Autoxidizing Xenobiotics and Metals: A Selective Critical Review and Commentary on Work‐in‐Progress

1984 • 170 citations

Protection Against Lethal Hyperoxia by Tracheal Insufflation of Erythrocytes: Role of Red Cell Glutathione

1985 • 169 citations

The role of antioxidants in the retina and retinal pigment epithelium and the nature of prooxidant-induced damage

1986 • 159 citations

Proteases and oxidants in experimental pulmonary inflammatory injury.

1984 • 158 citations

Hydroxymethyluracil DNA glycosylase in mammalian cells.

1984 • 157 citations

Free radical‐induced pathology

1985 • 150 citations

Formation of hydroxyl radicals in the presence of ferritin and haemosiderin. Is haemosiderin formation a biological protective mechanism?

1986 • 145 citations

Metal ions and oxygen radical reactions in human inflammatory joint disease

1985 • 142 citations

Effect of allopurinol on hemorrhagic shock

1969 • 140 citations

Effects of Superoxide Dismutase and Allopurinol on the Survival of Acute Island Skin Flaps

1985 • 137 citations

Effect of antioxidants on primary alloantigen-induced T cell activation and proliferation.

1986 • 136 citations

5,6-Saturated thymine lesions in DNA: production by ultraviolet light or hydrogen peroxide

1982 • 133 citations

Intact human erythrocytes prevent hydrogen peroxide-mediated damage to isolated perfused rat lungs and cultured bovine pulmonary artery endothelial cells.

1984 • 132 citations

Role of Free Radicals in Lung Injury

1986 • 132 citations

Alteration of superoxide dismutase activity in tracheal epithelial cells by asbestos and inhibition of cytotoxicity by antioxidants.

1986 • 128 citations

Hydrogen peroxide has a role in the aggregation of human platelets

1985 • 121 citations

Activated oxygen species at the origin of chromosome breakage and sister-chromatid exchanges

1982 • 120 citations

Monoclonal antibody to DNA containing thymine glycol

1983 • 119 citations

Cholesterol epoxide is a direct-acting mutagen.

1984 • 112 citations

Superoxide production by polymorphonuclear leucocytes in rheumatoid arthritis and osteoarthritis: in vivo inhibition by the antirheumatic drug piroxicam due to interference with the activation of the NADPH-oxidase.

1986 • 109 citations

The metal-mediated formation of hydroxyl radical by aqueous extracts of cigarette tar

1985 • 108 citations

Effect of antioxidants on lipid peroxidation in iron‐loaded rats

1984 • 104 citations

ESR spin-trapping study of the radicals produced in nitrogen oxide (NOx)/olefin reactions: a mechanism for the production of the apparently long-lived radicals in gas-phase cigaret smoke

1984 • 102 citations

Cigarette tar causes single-strand breaks in DNA

1985 • 102 citations

Carcinogenic Effects of Steroids

1969 • 101 citations

Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice

1984 • 101 citations

Age pigments and free radicals: fluorescent lipid complexes formed by iron- and copper-containing proteins

1985 • 93 citations

Iron Complexes and Their Reactivity in the Bleomycin Assay for Radical-Promoting Loosely-Bound Iron

1986 • 92 citations

Modulation of oxidant lung injury by using liposome-entrapped superoxide dismutase and catalase.

1985 • 92 citations

Effect of malonaldehyde and acetaldehyde on cultured mammalian cells

1982 • 90 citations

Free radicals, cell damage and disease

1986 • 89 citations

EVIDENCE OF FREE-RADICAL-INDUCED DAMAGE IN RABBIT KIDNEYS AFTER SIMPLE HYPOTHERMIC PRESERVATION AND AUTOTRANSPLANTATION

1986 • 86 citations

Red Cell Oxidative Damage

1985 • 86 citations

Are free radicals involved in tumor promotion?

1985 • 85 citations

Liposome-mediated augmentation of brain SOD and catalase inhibits CNS O2 toxicity

1984 • 85 citations

The possible role of free radical reactions in carcinogenesis.

1980 • 82 citations

Cholesterol and cholesterol epoxides in nipple aspirates of human breast fluid.

1981 • 80 citations

The effect of pH on yields of hydroxyl radicals produced from superoxide by potential biological iron chelators

1986 • 77 citations

There is no such thing as ageing, and cancer is not related to it.

1985 • 77 citations

Sealing of gaps in duplex DNA by T4 DNA ligase

1982 • 75 citations

Calcium-Dependent Neutral Proteases, Widespread Occurrence of a Species of Protease Active at Lower Concentrations of Calcium1

1981 • 72 citations

Effect of gentamicin on lipid peroxidation in rat renal cortex

1985 • 72 citations

Weiss Lecture

1984 • 60 citations

Inactivation of human α-1-proteinase inhibitor by gas-phase cigarette smoke

1984 • 56 citations

Measurement of the diene conjugated form of linoleic acid in plasma by high performance liquid chromatography: A questionable non-invasive assay of free radical activity?

1985 • 55 citations

Radioimmunoassay of a Thymine Glycol

1982 • 52 citations

Myocardial lipid peroxidation in rats after chronic alcohol ingestion and the effects of different antioxidants

1986 • 51 citations

Significance of increased blood uric acid following extensive hemorrhage

1968 • 51 citations

Chromosomal aberrations induced by hydrogen peroxide in cultured mammalian cells.

1981 • 49 citations

Radioimmunoassay of 7,8-dihydro-8-oxoadenine (8-hydroxyadenine)

1982 • 49 citations

Inhibition of mitochondrial electron transport by nor-dihydroguaiaretic acid (NDGA)

1970 • 47 citations

Redox activities of antitumor anthracyclines determined by microsomal oxygen consumption and assays for superoxide anion and hydroxyl radical generation

1986 • 46 citations

Chemical composition of cigarette smoke

1979 • 46 citations

Induction and characterization of gastro-duodenal lesions in mice given continuous oral administration of hydrogen peroxide.

1982 • 41 citations

Mechanisms of cigarette smoke toxicity: the inactivation of human α-1-proteinase inhibitor by nitric oxide/isoprene mixtures in air

1985 • 41 citations

Characterization of sister chromatid exchange induction by hydrogen peroxide

1982 • 41 citations

DNA Strand Scission by Activated Bleomycin Group Antibiotics

1987 • 40 citations

5-Azacytidine potentiates initiation induced by carcinogens in rat liver

1985 • 39 citations

Dietary practices of early life and spontaneous tumors of the Rat

1981 • 37 citations

Experimental Study of the Retinal Toxicity of Hemoglobinic Iron

1986 • 34 citations

THE EFFECT OF OXYGEN AND OF HYDROGEN PEROXIDE ON THE ACTION OF A SPECIFIC GENE AND ON TUMOR INDUCTION IN DROSOPHILA MELANOGASTER

1955 • 34 citations

Enhancing effect of hydrogen peroxide upon duodenal and upper jejunal carcinogenesis in rats.

1981 • 33 citations

Proteases, antiproteases, and oxidants: pathways of tissue injury during inflammation.

1982 • 31 citations

Effects of dietary fat and vitamin E on the lipid composition and stability of veal during frozen storage

1981 • 30 citations

Effect of blood on the activity and persistence of antigen induced inflammation in the rat air pouch.

1985 • 28 citations

Superoxide dismutase activity in early stages of development in normal and dystrophic chickens

1984 • 28 citations

Superoxide dismutase inhibits LTB4-induced leukotaxis

1985 • 26 citations

Oxidative DNA damage as related to cancer and aging.

1986 • 24 citations

Detection of risk of cancer to man

1979 • 24 citations

Identification of radiation-induced thymine derivatives in DNA

1982 • 21 citations

Production of thymine glycols in DNA by N-hydroxy-2-naphthylamine as detected by a monoclonal antibody.

1986 • 21 citations

DNA Methylation: Site‐Specific Methylations Cause Gene Inactivation

1984 • 20 citations

Lipids fromPlasmodium vinckei‐infected erythrocytes and their susceptibility to oxidative damage

1987 • 19 citations

THE CHEMISTRY AND BIOCHEMISTRY OF THE RADICALS IN CIGARETTE SMOKE: ESR EVIDENCE FOR THE BINDING OF THE TAR RADICAL TO DNA AND POLYNUCLEOTIDES

1984 • 17 citations

Endotoxin-tolerant rats are still protected from oxygen toxicity by low-dose endotoxin treatment

1985 • 12 citations

Erythrocyte antioxidant enzymes in multiple sclerosis and the effect of hyperbaric oxygen

1984 • 11 citations