Obesity and the placenta: A consideration of nutrient exchange mechanisms in relation to aberrant fetal growth
Data up to Jan 2025
Total Citations Per Year
Abstract
References (123)
TOR Signaling in Growth and Metabolism
2006 • 5,643 citations
Obesity and Overweight
2017 • 4,167 citations
Saving Mothers’ Lives: Reviewing maternal deaths to make motherhood safer: 2006–2008
2011 • 2,684 citations
Metabolic Syndrome in Childhood: Association With Birth Weight, Maternal Obesity, and Gestational Diabetes Mellitus
2005 • 2,244 citations
Maternal Morbid Obesity and the Risk of Adverse Pregnancy Outcome
2004 • 1,187 citations
Endovascular Trophoblast Invasion: Implications for the Pathogenesis of Intrauterine Growth Retardation and Preeclampsia
2003 • 1,178 citations
Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation
2002 • 1,132 citations
Obesity, obstetric complications and cesarean delivery rate–a population-based screening study
2004 • 1,129 citations
Foresight. Tackling obesities: future choices. Project report.
2007 • 833 citations
Review article: The short‐ and long‐term implications of maternal obesity on the mother and her offspring
2006 • 794 citations
Interpregnancy weight change and risk of adverse pregnancy outcomes: a population-based study
2006 • 732 citations
Fetal umbilical artery flow velocity waveforms and placental resistance: pathological correlation
1985 • 728 citations
Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy
1983 • 720 citations
Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype?
1994 • 696 citations
Effect of Body Mass Index on pregnancy outcomes in nulliparous women delivering singleton babies
2007 • 681 citations
Obesity in Pregnancy Stimulates Macrophage Accumulation and Inflammation in the Placenta
2008 • 670 citations
Placental Oxidative Stress: From Miscarriage to Preeclampsia
2004 • 647 citations
Longitudinal changes in glucose metabolism during pregnancy in obese women with normal glucose tolerance and gestational diabetes mellitus
1999 • 646 citations
Adiponectin: A Novel Adipokine Linking Adipocytes and Vascular Function
2004 • 641 citations
Maternal Obesity Is Associated with Dysregulation of Metabolic, Vascular, and Inflammatory Pathways
2002 • 634 citations
Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: systematic review and meta-analyses
2010 • 582 citations
Signalling role of adipose tissue: adipokines and inflammation in obesity
2005 • 568 citations
Oxygen and placental villous development: Origins of fetal hypoxia
1997 • 563 citations
The impact of maternal BMI status on pregnancy outcomes with immediate short‐term obstetric resource implications: a meta‐analysis
2008 • 516 citations
Gestational Weight Gain and Pregnancy Outcomes in Obese Women
2007 • 495 citations
Pre‐pregnancy weight and the risk of stillbirth and neonatal death
2005 • 479 citations
Carbohydrate metabolism during pregnancy in control subjects and women with gestational diabetes
1993 • 478 citations
The macrosomic fetus: a challenge in current obstetrics
2008 • 439 citations
Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree
1996 • 420 citations
Increased neonatal fat mass, not lean body mass, is associated with maternal obesity
2006 • 409 citations
Adiponectin in insulin resistance: lessons from translational research
2009 • 382 citations
Prepregnancy Obesity and Fetal Death
2005 • 350 citations
Pregnancy outcome and prepregnancy body mass index in 2459 glucose-tolerant Danish women
2003 • 345 citations
Brain Regulation of Appetite and Satiety
2008 • 341 citations
Pre‐pregnancy body mass index and pregnancy outcomes
2006 • 341 citations
Mechanisms by which poor early growth programs type-2 diabetes, obesity and the metabolic syndrome
2006 • 302 citations
Localization of Leptin Receptor mRNA Splice Variants in Murine Peripheral Tissues by RT-PCR andin SituHybridization
1997 • 300 citations
Pre-pregnancy Body Mass Index, Gestational Weight Gain, and Other Maternal Characteristics in Relation to Infant Birth Weight
2007 • 294 citations
High‐fat diet before and during pregnancy causes marked up‐regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice
2008 • 294 citations
Association between the Activity of the System A Amino Acid Transporter in the Microvillous Plasma Membrane of the Human Placenta and Severity of Fetal Compromise in Intrauterine Growth Restriction
1997 • 287 citations
Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy
1998 • 278 citations
Obesity and reproductive disorders: a review
1998 • 273 citations
Stereological Investigation of Placental Morphology in Pregnancies Complicated by Pre-eclampsia with and without Intrauterine Growth Restriction
2003 • 272 citations
Down‐regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet
2003 • 261 citations
The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia
2005 • 260 citations
Changes in booking body mass index over a decade: retrospective analysis from a Glasgow Maternity Hospital
2005 • 259 citations
Amino Acid (System A) Transporter Activity in Microvillous Membrane Vesicles from the Placentas of Appropriate and Small for Gestational Age Babies
1993 • 245 citations
Leptin Stimulates the Activity of the System A Amino Acid Transporter in Human Placental Villous Fragments
2003 • 245 citations
Placental Phenotypes of Intrauterine Growth
2005 • 244 citations
Maternal obesity and pregnancy outcomes
2002 • 238 citations
Placental Transport of Leucine and Lysine Is Reduced in Intrauterine Growth Restriction1
1998 • 230 citations
Impact of maternal body mass index on neonate birthweight and body composition
2008 • 228 citations
Placental Transport of Leucine, Phenylalanine, Glycine, and Proline in Intrauterine Growth-Restricted Pregnancies
2001 • 205 citations
Intrauterine Growth Restriction Is Associated with a Reduced Activity of Placental Taurine Transporters
1998 • 202 citations
Insulin and the IGF system in the human placenta of normal and diabetic pregnancies
2009 • 199 citations
Trophoblast apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression
2002 • 195 citations
Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus
2009 • 191 citations
Prospective cohort study of factors influencing the relative weights of the placenta and the newborn infant
1997 • 187 citations
Trends in maternal obesity and associated risks of adverse pregnancy outcomes in a population of Chinese women
2008 • 186 citations
Endothelial nitric oxide synthase in placental villous tissue from normal, pre-eclamptic and intrauterine growth restricted pregnancies
1997 • 181 citations
Adipocytokines in Normal and Complicated Pregnancies
2009 • 181 citations
IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2
2009 • 167 citations
The IGF Axis and Placental Function
2008 • 158 citations
Umbilical doppler waveforms and placental villous angiogenesis in pregnancies complicated by fetal growth restriction
1999 • 157 citations
Maternal anthropometric and metabolic factors in the first half of pregnancy and risk of neonatal macrosomia in term pregnancies. A prospective study
2005 • 155 citations
Maternal hormones linking maternal body mass index and dietary intake to birth weight
2008 • 154 citations
Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling
2009 • 154 citations
Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet
2006 • 153 citations
Adipokines and insulin resistance during pregnancy
2008 • 152 citations
Placental mTOR links maternal nutrient availability to fetal growth
2009 • 146 citations
Placental Amino Acid Transport and Placental Leptin Resistance in Pregnancies Complicated by Maternal Obesity
2010 • 145 citations
Linear association between maternal pre‐pregnancy body mass index and risk of caesarean section in term deliveries
2006 • 144 citations
Decreased vascularization and cell proliferation in placentas of intrauterine growth–restricted fetuses with abnormal umbilical artery flow velocity waveforms
2002 • 142 citations
Intrauterine programming of coronary heart disease and stroke
1997 • 141 citations
Decreased plasma adiponectin concentrations in women with gestational diabetes mellitus
2004 • 140 citations
From feeding one to feeding many: hormone‐induced changes in bodyweight homeostasis during pregnancy
2007 • 129 citations
Leptin Promotes Cell Proliferation and Survival of Trophoblastic Cells1
2006 • 127 citations
Full-Length Adiponectin Attenuates Insulin Signaling and Inhibits Insulin-Stimulated Amino Acid Transport in Human Primary Trophoblast Cells
2010 • 125 citations
The Placenta in Pre-eclampsia and Intrauterine Growth Restriction: Studies on Exchange Surface Areas, Diffusion Distances and Villous Membrane Diffusive Conductances
2006 • 122 citations
Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight
1996 • 120 citations
Developmental origins of adult metabolic disease: concepts and controversies
2005 • 118 citations
Insulin‐like growth factor‐1 stimulates amino acid uptake by the cultured human placental trophoblast
1995 • 113 citations
Diabetes and obesity during pregnancy alter insulin signalling and glucose transporter expression in maternal skeletal muscle and subcutaneous adipose tissue
2009 • 111 citations
Amino acid transport by the cultured human placental trophoblast: effect of insulin on AIB transport
1992 • 110 citations
Maternal anthropometrics are associated with fetal size in different periods of pregnancy and at birth. The Generation R Study
2009 • 110 citations
Nitric oxide concentrations are increased in the feto-placental circulation in intrauterine growth restriction
1996 • 104 citations
Changes in prepregnancy body mass index between the first and second pregnancies and risk of large-for-gestational-age birth
2007 • 99 citations
Fetal and maternal plasma insulin-like growth factors and binding proteins in pregnancies with appropriate or retarded fetal growth
1997 • 96 citations
Placental Transport and Metabolism in Fetal Overgrowth – A Workshop Report
2006 • 94 citations
Leptin and adiponectin concentrations in intrauterine growth restricted and appropriate for gestational age fetuses, neonates, and their mothers
2008 • 91 citations
Modifiable determinants of fetal macrosomia: role of lifestyle‐related factors
2008 • 88 citations
Activity and Protein Expression of Na+/K+ATPase Are Reduced in Microvillous Syncytiotrophoblast Plasma Membranes Isolated from Pregnancies Complicated by Intrauterine Growth Restriction
2003 • 88 citations
Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transport
2007 • 84 citations
Prepregnancy body mass index and adverse pregnancy outcomes
2007 • 82 citations
Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway
2008 • 81 citations
Effect of maternal metabolism on fetal growth and body composition.
1998 • 79 citations
Nitric oxide synthase in human placenta and umbilical cord from normal, intrauterine growth‐retarded and pre‐eclamptic pregnancies
1995 • 77 citations
Interpregnancy Weight Change and Risk of Adverse Pregnancy Outcomes: A Population-based Study
2007 • 76 citations
Short communication: A longitudinal study of serum adiponectin during normal pregnancy
2005 • 76 citations
Trophoblast in Human Utero-Placental Arteries
1966 • 73 citations
Maternal and anthropomorphic risk factors for shoulder dystocia
2006 • 71 citations
Prepregnancy body mass index, hypertensive disorders of pregnancy, and long-term maternal mortality
2007 • 65 citations
Maternal and fetal origins of coronary heart disease.
1994 • 64 citations
Fetoplacental growth and vascular development in overnourished adolescent sheep at day 50, 90 and 130 of gestation
2009 • 59 citations
CHILDHOOD OBESITY, HYPERTENSION, THE METABOLIC SYNDROME AND ADULT CARDIOVASCULAR DISEASE
2008 • 56 citations
Morbid obesity and intra-partum care
2008 • 56 citations
Increase in normal placental weights related to increase in maternal body mass index
2008 • 52 citations
Glucose Metabolism Is Elevated and Vascular Resistance and Maternofetal Transfer Is Normal in Perfused Placental Cotyledons from Severely Growth-Restricted Fetuses
2000 • 50 citations
Oxygen diffusive conductance in placentae from control and diabetic women
1993 • 45 citations
Peripheral Factors in the Metabolic Syndrome
2006 • 41 citations
Body mass index: a true indicator of body fat in obese gravidas.
2007 • 41 citations
Adiponectin Predicts Insulin Resistance But Not Endothelial Function in Young, Healthy Adolescents
2005 • 38 citations
Adipokines and coronary vasomotor dysfunction.
2007 • 38 citations
Mechanisms of Transfer Across the Human Placenta
2016 • 36 citations
A Comparison of Circulating TNF-α in Obese and Lean Women with and without Preeclampsia
2008 • 36 citations
The relation of insulin, leptin and IGF‐1 to birthweight in offspring of women with type 1 diabetes
2004 • 36 citations
Placenta morphology and absent or reversed end diastolic flow velocities in the umbilical artery: a clinical and morphometrical study
1996 • 34 citations
Morphometry of the microvillous membrane of the human placenta in maternal diabetes mellitus
1986 • 33 citations
Maternal serum adiponectin multimers in patients with a small-for-gestational-age newborn
2009 • 27 citations
Reactivity of Human Placental Chorionic Plate Vessels from Pregnancies Complicated by Intrauterine Growth Restriction (IUGR)1
2006 • 25 citations
The effect of intraperitoneal administration of leptin on short-term food intake in rats
2007 • 19 citations
Prepregnancy Body Mass Index, Hypertensive Disorders of Pregnancy, and Long-term Maternal Mortality
2008 • 12 citations
Mechanisms of Transfer Across the Human Placenta
2004 • 11 citations