Placental mTOR links maternal nutrient availability to fetal growth

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

2003 • 3,731 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 • 2,574 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 • 2,561 citations

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

2008 • 2,551 citations

Living with the Past: Evolution, Development, and Patterns of Disease

2004 • 1,804 citations

Regulation of TORC1 by Rag GTPases in nutrient response

2008 • 1,260 citations

Hypothalamic mTOR Signaling Regulates Food Intake

2006 • 1,217 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

A Nutrient Sensor Mechanism Controls Drosophila Growth

2003 • 769 citations

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

2005 • 744 citations

mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells

2004 • 606 citations

Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

2002 • 580 citations

hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase

2005 • 519 citations

Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

2004 • 464 citations

A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets

2003 • 460 citations

Serum Insulin-Like Growth Factors and Insulin-Like Growth Factor Binding Proteins in the Human Fetus. Relationships with Growth in Normal Subjects and in Subjects with Intrauterine Growth Retardation

1991 • 415 citations

The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation

2002 • 394 citations

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

2008 • 359 citations

Starvation Induces Vacuolar Targeting and Degradation of the Tryptophan Permease in Yeast

1999 • 289 citations

Mammalian target of rapamycin in the human placenta regulates leucine transport and is down‐regulated in restricted fetal growth

2007 • 270 citations

Umbilical amino acid concentrations in normal and growth-retarded fetuses sampled in utero by cordocentesis

1990 • 261 citations

Down‐regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet

2003 • 261 citations

Human Placental Transport in Altered Fetal Growth: Does the Placenta Function as a Nutrient Sensor? – A Review

2006 • 250 citations

Amino Acid (System A) Transporter Activity in Microvillous Membrane Vesicles from the Placentas of Appropriate and Small for Gestational Age Babies

1993 • 245 citations

Placental Transport of Leucine and Lysine Is Reduced in Intrauterine Growth Restriction1

1998 • 230 citations

Alterations in the Activity of Placental Amino Acid Transporters in Pregnancies Complicated by Diabetes

2002 • 226 citations

Blood glucose and oxygen tension levels in small-for-gestational-age fetuses

1989 • 207 citations

l-Leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the l-leucine-induced up-regulation of System A amino acid transport

2000 • 205 citations

Placental Transport of Leucine, Phenylalanine, Glycine, and Proline in Intrauterine Growth-Restricted Pregnancies

2001 • 205 citations

Intrauterine Growth Restriction Is Associated with a Reduced Activity of Placental Taurine Transporters

1998 • 202 citations

Placental Growth Hormone Levels in Normal Pregnancy and in Pregnancies with Intrauterine Growth Retardation

1993 • 196 citations

Exogenous Amino Acids Regulate Trophectoderm Differentiation in the Mouse Blastocyst through an mTOR-Dependent Pathway

2001 • 186 citations

Management of fetal growth restriction

2006 • 184 citations

Trends in fetal growth among singleton gestations in the United States and Canada, 1985 through 1998

2002 • 183 citations

Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells.

2003 • 167 citations

Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet

2006 • 153 citations

Tissue concentrations of free amino acids in term human placentas

1978 • 145 citations

TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth

2006 • 144 citations

Regulation of placental amino acid transporter activity by mammalian target of rapamycin

2008 • 139 citations

mTOR: A placental growth signaling sensor

2005 • 98 citations

Intrauterine growth retardation at term: association between anthropometric and endocrine parameters

1996 • 97 citations

An activated mTOR mutant supports growth factor-independent, nutrient-dependent cell survival

2004 • 88 citations

Regulation of Leucine Uptake by tor1+ in Schizosaccharomyces pombe Is Sensitive to Rapamycin

2004 • 84 citations

Platelet‐derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: Role in cell growth

2004 • 76 citations

Controlling cell growth and survival through regulated nutrient transporter expression

2007 • 69 citations

Rapamycin regulates the phosphorylation of rictor

2007 • 62 citations