Insulin and the IGF system in the human placenta of normal and diabetic pregnancies

Phenotypic Heterogeneity of the Endothelium

2007 • 1,180 citations

Intrauterine Growth Retardation and Postnatal Growth Failure Associated with Deletion of the Insulin-Like Growth Factor I Gene

1996 • 1,094 citations

The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily*

1999 • 1,008 citations

Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

1999 • 865 citations

IGF-I Receptor Mutations Resulting in Intrauterine and Postnatal Growth Retardation

2003 • 600 citations

Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway

2002 • 527 citations

Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved

2002 • 492 citations

The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily

1999 • 473 citations

Monoclonal antibodies to receptors for insulin and somatomedin-C.

1983 • 423 citations

Molecular interactions of the IGF system

2005 • 418 citations

Role of insulin-like growth factor binding proteins in controlling IGF actions

1998 • 401 citations

Gestational Diabetes Induces Placental Genes for Chronic Stress and Inflammatory Pathways

2003 • 376 citations

Insulin-Like Growth Factor Binding Proteins in Maternal Serum Throughout Gestation and in the Puerperium: Effects of a Pregnancy-Associated Serum Protease Activity*

1990 • 368 citations

Functional Role of Cell Surface Integrins on Human Trophoblast Cell Migration: Regulation by TGF-β, IGF-II, and IGFBP-1

1995 • 358 citations

Evidence of Enzymatic Degradation of Insulin-Like Growth Factor-Binding Proteins in the 150K Complex during Pregnancy*

1990 • 349 citations

The Human Placenta in Gestational Diabetes Mellitus

2007 • 326 citations

Insulin Secretion during and after Pregnancy in Patients with Gestational Diabetes Mellitus¹

2001 • 206 citations

Insulin-like growth factor I and II regulate the life cycle of trophoblast in the developing human placenta

2008 • 178 citations

Autocrine-Paracrine Regulation of Human Trophoblast Invasiveness by Insulin-like Growth Factor (IGF)-II and IGF-Binding Protein (IGFBP)-1

1998 • 178 citations

Spatial and Temporal Patterns of Expression of Messenger RNA for Insulin-Like Growth Factors and their Binding Proteins in the Placenta of Man and Laboratory Animals

2000 • 171 citations

Insulinlike growth factors. Their regulation of glucose and amino acid transport in placental trophoblasts isolated from first-trimester chorionic villi.

1994 • 170 citations

The fetal vascularisation of term human placental villi

1985 • 168 citations

The IGF Axis and Placental Function

2008 • 158 citations

Maternal and fetal amino acid concentrations in normal pregnancies and in pregnancies with gestational diabetes mellitus

2005 • 153 citations

The phosphorylation pattern of insulin-like growth factor-binding protein-1 in normal plasma is different from that in amniotic fluid and changes during pregnancy.

1994 • 153 citations

Insulin Secretion during and after Pregnancy in Patients with Gestational Diabetes Mellitus

2001 • 134 citations

Cell Proliferation Activities on Skin Fibroblasts from a Short Child with Absence of One Copy of the Type 1 Insulin-Like Growth Factor Receptor (IGF1R) Gene and a Tall Child with Three Copies of the IGF1R Gene

2003 • 124 citations

Fetoplacental Angiogenesis During Gestation is Biphasic, Longitudinal and Occurs by Proliferation and Remodelling of Vascular Endothelial Cells

2002 • 117 citations

Insulin‐like growth factor‐1 stimulates amino acid uptake by the cultured human placental trophoblast

1995 • 113 citations

Human fetal placental endothelial cells have a mature arterial and a juvenile venous phenotype with adipogenic and osteogenic differentiation potential

2008 • 110 citations

Insulin control of placental gene expression shifts from mother to foetus over the course of pregnancy

2005 • 103 citations

Topological Properties and Spatial Organization of Villous Capillaries in Normal and Diabetic Placentas

2002 • 101 citations

Insulin-like growth factor axis during embryonic development

2001 • 101 citations

Insulin receptors in syncytitrophoblast and fetal endothelium of human placenta. Immunohistochemical evidence for developmental changes in distribution pattern

1994 • 92 citations

Congenital Absence of the Pancreas and Intrauterine Growth Retardation

1979 • 89 citations

Insulin binding to trophoblast plasma membranes and placental glycogen content in well-controlled gestational diabetic women treated with diet or insulin, in well-controlled overt diabetic patients and in healthy control subjects

1992 • 88 citations

Chronic Hyperinsulinemia in the Fetal Rhesus Monkey: Effects of Physiologic Hyperinsulinemia on Fetal Growth and Composition

1984 • 86 citations

Matrix Metalloprotease-3 and -9 Proteolyze Insulin-Like Growth Factor-Binding Protein-11

2004 • 85 citations

Immunohistochemical localization of insulin-like growth factors (IGFs) and IGF binding proteins-1, -2 and -3 in human placenta and fetal membranes

1993 • 80 citations

Three-Dimensional Representation of the Fetal Vessel System in the Human Placenta

1988 • 78 citations

Placental lipid and glycogen content in human and experimental diabetes mellitus

1982 • 76 citations

Insulin-like growth factors (IGFs) and IGF binding proteins-1, -2, and -3 in newborn serum: relationships to fetoplacental growth at term

1996 • 75 citations

Location of insulin receptors in the placenta and its progenitor tissues

1997 • 72 citations

Hyperinsulinemia in Cord Blood in Mothers With Type 2 Diabetes and Gestational Diabetes Mellitus in New Zealand

2006 • 70 citations

The fetal vascularisation of term human placental villi

1985 • 68 citations

Inverse changes in fetal insulin‐like growth factor (IGF)‐1 and IGF binding protein‐1 in association with higher birth weight in maternal diabetes

2007 • 67 citations

Insulin and Glucose Do not Affect the Glycogen Content in Isolated and Cultured Trophoblast Cells of Human Term Placenta

1991 • 63 citations

Fetoplacental Angiogenesis During Gestation is Biphasic, Longitudinal and Occurs by Proliferation and Remodelling of Vascular Endothelial Cells

2002 • 60 citations

The phosphorylation pattern of insulin-like growth factor-binding protein-1 in normal plasma is different from that in amniotic fluid and changes during pregnancy

1994 • 60 citations

Relation of cord plasma concentrations of proinsulin, 32–33 split proinsulin, insulin and C-peptide to placental weight and the baby's size and proportions at birth

1996 • 58 citations

MT1-MMP Expression in First-Trimester Placental Tissue Is Upregulated in Type 1 Diabetes as a Result of Elevated Insulin and Tumor Necrosis Factor-α Levels

2007 • 57 citations

Vascular endothelial cadherin and �-catenin in human fetoplacental vessels of pregnancies complicated by Type 1 diabetes: associations with angiogenesis and perturbed barrier function

2004 • 56 citations

Tissue-specific expression of insulin-like growth factor binding protein-3 protease activity during rat pregnancy.

1992 • 56 citations

The role of 5 1-integrin in the IGF-I-induced migration of extravillous trophoblast cells during the process of implantation

2004 • 55 citations

Phosphorylated insulin-like growth factor binding protein 1 is increased in pregnant diabetic subjects.

1999 • 53 citations

Insulin-Like Growth Factors (IGFs) and IGF-Binding Proteins (IGFBP-1, -2 and -3) in Diabetic Pregnancy: Relationship to Macrosomia.

1996 • 45 citations

Insulin-Like Growth Factors I and II Peptide and Messenger RNA Levels in Macrosomic Infants of Diabetic Pregnancies

1996 • 44 citations

Insulin-like growth factor-I as a local regulator of proliferation and differentiated function of the human trophoblast in early pregnancy.

1995 • 44 citations

Regulation of human villous trophoblast by insulin-like growth factors and insulin-like growth factor-binding protein-1

2004 • 43 citations

Insulin and Insulin Propeptides at Birth in Offspring of Diabetic Mothers

2003 • 40 citations

Effect of insulin on human chorionic gonadotrophin secretion by placental explants

1993 • 37 citations

Chronic hyperinsulinemia in the fetal rhesus monkey. Effects of physiologic hyperinsulinemia on fetal growth and composition

1984 • 36 citations

Metabolic Effects of Growth Factors and Polycyclic Aromatic Hydrocarbons on Cultured Human Placental Cells of Early and Late Gestation*

1991 • 35 citations

Mutations in the Glucokinase Gene of the Fetus Result in Reduced Placental Weight

2008 • 34 citations

Epidermal Growth Factor and Insulin-like Growth Factor I Differently Influence the Directional Accumulation and Transfer of 2-Aminoisobutyrate (AIB) by Human Placental Trophoblast in Two-Sided Culture

1994 • 34 citations

Glycogen distribution in the capillaries of the placental villus in normal, overt and gestational diabetic pregnancy

1993 • 33 citations

Insulin and fatty acids regulate the expression of the fat droplet-associated protein adipophilin in primary human trophoblasts

2005 • 31 citations

Expression of Messenger RNA of Insulin-Like Growth Factors (IGFs) and IGF Binding Proteins (IGFBP1-6) in Placenta of Normal and Diabetic Pregnancy.

1996 • 30 citations

Characterization of Morphological and Cytoskeletal Changes in Trophoblast Cells Induced by Insulin-Like Growth Factor-I

2002 • 30 citations

Insulin-like growth factors I and II peptide and messenger RNA levels in macrosomic infants of diabetic pregnancies

1996 • 28 citations

Expression of insulin-like growth factor in the placenta of intrauterine growth-retarded human fetuses

2001 • 28 citations

Maternal serum level of placental growth factor in diabetic pregnancies.

2004 • 28 citations

Insulin-like growth factors (IGF) I and II in diabetic pregnancy: Suppression of normal pregnancy-induced rise of IGF-I

1986 • 27 citations

Reproductive toxicity of ofloxacin.

1986 • 27 citations

beta-Thalassemia in Southern Italy: a preliminary approach.

1982 • 25 citations

Cellular Localization of Insulin-Like Growth Factor II mRNA in the Human Fetus and the Placenta: Detection with a Digoxigenin-Labeled cRNA Probe and Immunocytochemistry

1998 • 25 citations

Could abnormalities in insulin-like growth factors and their binding proteins during pregnancy result in gestational diabetes?

1995 • 23 citations

Tissue-specific expression of insulin-like growth factor binding protein-3 protease activity during rat pregnancy

1992 • 20 citations

Patterns in expression of insulin-like growth factor-II and of proliferative activity in the normal human first and third trimester placenta demonstrated by non-isotopic in situ hybridization and immunohistochemical staining for MIB-1

1997 • 19 citations

The insulin-like growth factor system and Type 1 diabetic retinopathy during pregnancy

2005 • 15 citations

Role of Adiponectin in Matching of Fetal and Placental Weight in Mothers With Type 1 Diabetes

2008 • 15 citations

Growth Promoting Peptides in Diabetic and Non-Diabetic Pregnancy: Interactions with Trophoblastic Receptors and Serum Carrier Proteins

1996 • 14 citations

The serum insulin-like growth factor-II/mannose-6-phosphate receptor in normal and diabetic pregnancy

1993 • 13 citations

The placenta in diabetic pregnancy: Placental transfer of nutrients

2008 • 8 citations

Cord serum insulin-like growth factor binding protein-1 and -3: effect of maternal diabetes and relationships to fetal growth

2005 • 7 citations