Adiponectin in insulin resistance: lessons from translational research

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

1999 • 4,825 citations

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

1995 • 3,159 citations

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

2003 • 3,114 citations

AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

1996 • 2,229 citations

cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)

1996 • 2,082 citations

PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein

2001 • 1,659 citations

Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex

2003 • 1,456 citations

ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism

2002 • 1,210 citations

Adiponectin and development of type 2 diabetes in the Pima Indian population

2002 • 1,111 citations

Adiponectin Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice

2002 • 1,028 citations

Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells

2003 • 980 citations

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms

2005 • 956 citations

Adiponectin Levels and Risk of Type 2 Diabetes

2009 • 938 citations

Isolation and Characterization of GBP28, a Novel Gelatin-Binding Protein Purified from Human Plasma

1996 • 919 citations

Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

2007 • 794 citations

The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects

2002 • 722 citations

Adipocyte-Derived Plasma Protein Adiponectin Acts as a Platelet-Derived Growth Factor-BB–Binding Protein and Regulates Growth Factor–Induced Common Postreceptor Signal in Vascular Smooth Muscle Cell

2002 • 697 citations

Adiponectin: A Novel Adipokine Linking Adipocytes and Vascular Function

2004 • 641 citations

Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPARγ Agonists: A Potential Mechanism of Insulin Sensitization

2002 • 575 citations

Adiponectin and Breast Cancer Risk

2004 • 534 citations

Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-α

2003 • 517 citations

Low Plasma Adiponectin Levels and Risk of Colorectal Cancer in Men: A Prospective Study

2005 • 492 citations

AMPK, the metabolic syndrome and cancer

2005 • 415 citations

Adiponectin and Future Coronary Heart Disease Events Among Men With Type 2 Diabetes

2005 • 378 citations

Correlation Between Adiponectin, Tumor Necrosis Factor-alpha, Insulin Resistance and Atherogenic Dyslipidemia in Non Diabetic Central Obese Males

2010 • 296 citations

Circulating Adiponectin and Expression of Adiponectin Receptors in Human Skeletal Muscle: Associations with Metabolic Parameters and Insulin Resistance and Regulation by Physical Training

2006 • 285 citations

Circulating Adiponectin and Endometrial Cancer Risk

2004 • 254 citations

Plasma Adiponectin and Gastric Cancer

2005 • 250 citations

Plasma Adiponectin Concentrations in Relation to Endometrial Cancer: A Case-Control Study in Greece

2003 • 233 citations

Circulating Adiponectin Levels Are Associated with Better Glycemic Control, More Favorable Lipid Profile, and Reduced Inflammation in Women with Type 2 Diabetes

2005 • 221 citations

Total and High-Molecular-Weight Adiponectin and Resistin in Relation to the Risk for Type 2 Diabetes in Women

2008 • 210 citations

Plasma Adiponectin Levels and Endometrial Cancer Risk in Pre- and Postmenopausal Women

2006 • 205 citations

Fibroblast growth factor 21: from pharmacology to physiology

2009 • 202 citations

When translation meets transformation: the mTOR story

2006 • 199 citations

Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women1–3

2006 • 195 citations

A prospective study of plasma levels of insulin-like growth factor I (IGF-I) and IGF-binding protein-3, and colorectal cancer risk among men

2000 • 181 citations

Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition

2008 • 181 citations

Serum Adiponectin Concentrations and Tissue Expression of Adiponectin Receptors Are Reduced in Patients with Prostate Cancer: A Case Control Study

2007 • 175 citations

Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women

2006 • 174 citations

Association between dietary factors and plasma adiponectin concentrations in men

2005 • 158 citations

Coffee Consumption Is Associated With Higher Plasma Adiponectin Concentrations in Women With or Without Type 2 Diabetes

2008 • 155 citations

Selective peroxisome proliferator-activated receptor γ (PPARγ) modulation as a strategy for safer therapeutic PPARγ activation

2009 • 153 citations

Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice

2006 • 145 citations

Hyperadiponectinaemia in anorexia nervosa

2003 • 132 citations

Total and High–Molecular Weight Adiponectin in Relation to Metabolic Variables at Baseline and in Response to an Exercise Treatment Program

2007 • 126 citations

Brown adipocytes are novel sites of expression and regulation of adiponectin and resistin

2002 • 122 citations

Adiponectin activates c-Jun NH2-terminal kinase and inhibits signal transducer and activator of transcription 3

2005 • 122 citations

Variants of the Adiponectin and Adiponectin Receptor 1 Genes and Breast Cancer Risk

2008 • 115 citations

Gene Expression of Adiponectin Receptors in Human Visceral and Subcutaneous Adipose Tissue Is Related to Insulin Resistance and Metabolic Parameters and Is Altered in Response to Physical Training

2007 • 111 citations

Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case–control study

2008 • 110 citations

Adiponectin blocks multiple signaling cascades associated with leptin‐induced cell proliferation in Apc^Min/+ colon epithelial cells

2008 • 91 citations

Lower Plasma Adiponectin Levels Are Associated with Larger Tumor Size and Metastasis in Clear-Cell Carcinoma of the Kidney

2008 • 88 citations

Responsiveness to Peripherally Administered Melanocortins in Lean and Obese Mice

2004 • 86 citations

Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors

2008 • 81 citations

The Development of INT131 as a Selective PPARγ Modulator: Approach to a Safer Insulin Sensitizer

2008 • 77 citations

Decreased Serum Adiponectin Levels in Patients with Metastatic Renal Cell Carcinoma

2008 • 55 citations

Adiponectin and Adiponectin Receptors in Obesity‐Linked Insulin Resistance

2007 • 52 citations

Circulating Adiponectin and Leptin in Relation to Myelodysplastic Syndrome: A Case-Control Study

2007 • 51 citations

Peroxisome proliferator-activated receptor translational research and clinical experience

2009 • 41 citations

From bench to bedside: novel mechanisms and therapeutic advances through the development of selective peroxisome proliferator-activated receptor γ modulators

2009 • 18 citations