Signalling role of adipose tissue: adipokines and inflammation in obesity

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 8,349 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 7,795 citations

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

2003 • 5,744 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

2003 • 5,391 citations

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

1999 • 4,825 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

2001 • 2,534 citations

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction

1999 • 2,478 citations

Adipokines: inflammation and the pleiotropic role of white adipose tissue

2004 • 2,127 citations

Prevalence of obesity in the United States, 2009-2010.

2012 • 1,989 citations

Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?

2000 • 1,753 citations

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

2001 • 1,743 citations

Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway

2000 • 1,711 citations

Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women

2003 • 1,474 citations

Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ

2001 • 1,216 citations

Obesity in Britain: gluttony or sloth?

1995 • 1,202 citations

Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis

2003 • 1,192 citations

HIF-1 and mechanisms of hypoxia sensing

2001 • 1,131 citations

Cellular adaptation to hypoxia: O₂‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O₂‐regulated gene expression

2002 • 1,114 citations

The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation

2001 • 969 citations

Inflammatory mediators in the elderly

2004 • 899 citations

Inflammatory pathways and insulin action

2003 • 716 citations

The relation of body fat mass and distribution to markers of chronic inflammation

2001 • 699 citations

Muscle‐derived interleukin‐6: possible biological effects

2001 • 580 citations

Integrative physiology of human adipose tissue

2003 • 449 citations

Prevalence of obesity in Great Britain

2005 • 404 citations

Adipsin: A Circulating Serine Protease Homolog Secreted by Adipose Tissue and Sciatic Nerve

1987 • 398 citations

Adipose tissue, insulin action and vascular disease: inflammatory signals

2003 • 320 citations

A role for preadipocytes as macrophage‐like cells

1999 • 319 citations

Severely Impaired Adipsin Expression in Genetic and Acquired Obesity

1987 • 319 citations

Tumor Necrosis Factor-α Induces Apoptosis of Human Adipose Cells

1997 • 305 citations

Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1

2004 • 284 citations

Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes.

1993 • 276 citations

The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor?

2004 • 261 citations

Inflammation-Sensitive Plasma Proteins Are Associated With Future Weight Gain

2003 • 250 citations

Regulation of leptin production: sympathetic nervous system interactions

2001 • 245 citations

Weight Loss Reduces Interleukin-18 Levels in Obese Women

2002 • 236 citations

Leptin—Much More Than a Satiety Signal

2000 • 222 citations

Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes

2003 • 215 citations

HIFs and tumors—causes and consequences

2004 • 189 citations

Impaired Postprandial Adipose Tissue Blood Flow Response Is Related to Aspects of Insulin Sensitivity

2002 • 170 citations

Tumor Necrosis Factor α Stimulates Lipolysis in Adipocytes by Decreasing Gi Protein Concentrations

1999 • 144 citations

The inflammatory side of human chondrocytes unveiled by antibody microarrays

2004 • 84 citations

Adipose tissues display differential phagocytic and microbicidal activities depending on their localization

2001 • 61 citations