Full-Length Adiponectin Attenuates Insulin Signaling and Inhibits Insulin-Stimulated Amino Acid Transport in Human Primary Trophoblast Cells

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 4,335 citations

Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia

2001 • 3,408 citations

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

2003 • 3,114 citations

Adiponectin and Adiponectin Receptors

2005 • 2,543 citations

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

2001 • 2,534 citations

Metabolic Syndrome in Childhood: Association With Birth Weight, Maternal Obesity, and Gestational Diabetes Mellitus

2005 • 2,244 citations

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

2001 • 1,903 citations

Purification, Characterization, andin vitroDifferentiation of Cytotrophoblasts from Human Term Placentae*

1986 • 1,556 citations

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

2007 • 1,305 citations

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

1996 • 1,222 citations

ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism

2002 • 1,210 citations

APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

2006 • 636 citations

Maternal Obesity Is Associated with Dysregulation of Metabolic, Vascular, and Inflammatory Pathways

2002 • 634 citations

Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism

2003 • 591 citations

Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α

2006 • 507 citations

PTEN function: how normal cells control it and tumour cells lose it

2004 • 441 citations

Identification of a Membrane Protein, LAT-2, That Co-expresses with 4F2 Heavy Chain, an L-type Amino Acid Transport Activity with Broad Specificity for Small and Large Zwitterionic Amino Acids

1999 • 395 citations

Attenuation of leptin and insulin signaling by SOCS proteins

2006 • 366 citations

Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells

2004 • 334 citations

Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases

2008 • 331 citations

p38 MAPK and NF-κB Collaborate to Induce Interleukin-6 Gene Expression and Release

2000 • 330 citations

Generation of Globular Fragment of Adiponectin by Leukocyte Elastase Secreted by Monocytic Cell Line THP-1

2004 • 318 citations

High‐fat diet before and during pregnancy causes marked up‐regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice

2008 • 294 citations

APPL1: role in adiponectin signaling and beyond

2008 • 277 citations

Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism

2007 • 273 citations

Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines

2006 • 263 citations

Down‐regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet

2003 • 261 citations

A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes

2005 • 259 citations

Human Placental Transport in Altered Fetal Growth: Does the Placenta Function as a Nutrient Sensor? – A Review

2006 • 250 citations

Leptin Stimulates the Activity of the System A Amino Acid Transporter in Human Placental Villous Fragments

2003 • 245 citations

Expression and Regulation of Adiponectin and Receptor in Human and Rat Placenta

2005 • 237 citations

Adiponectin Enhances IL-6 Production in Human Synovial Fibroblast via an AdipoR1 Receptor, AMPK, p38, and NF-κB Pathway

2007 • 235 citations

Leptin and Adiponectin Stimulate the Release of Proinflammatory Cytokines and Prostaglandins from Human Placenta and Maternal Adipose Tissue via Nuclear Factor-κB, Peroxisomal Proliferator-Activated Receptor-γ and Extracellularly Regulated Kinase 1/2

2005 • 230 citations

Alterations in the Activity of Placental Amino Acid Transporters in Pregnancies Complicated by Diabetes

2002 • 226 citations

Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1

2007 • 210 citations

Regulation of Placental Nutrient Transport – A Review

2007 • 206 citations

Triglyceride Hydrolase Activities and Expression of Fatty Acid Binding Proteins in the Human Placenta in Pregnancies Complicated by Intrauterine Growth Restriction and Diabetes

2004 • 193 citations

IL-6 signalling in exercise and disease

2007 • 179 citations

Carbohydrate metabolism in pregnancy

1981 • 170 citations

Adiponectin Expression in Human Fetal Tissues during Mid- and Late Gestation

2005 • 168 citations

Placental glucose transport and GLUT 1 expression in insulin-dependent diabetes

1999 • 167 citations

IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2

2009 • 167 citations

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

2005 • 166 citations

PPAR Action in Human Placental Development and Pregnancy and Its Complications

2007 • 164 citations

Carbohydrate Metabolism in Pregnancy. XVII. Diurnal Profiles of Plasma Glucose, Insulin, Free Fatty Acids, Triglycerides, Cholesterol, and Individual Amino Acids in Late Normal Pregnancy

1981 • 162 citations

Adiponectin is reduced in gestational diabetes mellitus in normal weight women

2004 • 155 citations

Maternal hormones linking maternal body mass index and dietary intake to birth weight

2008 • 154 citations

Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet

2006 • 153 citations

Peroxisome Proliferator–Activated Receptor α Activation Decreases Metastatic Potential of Melanoma Cells In vitro via Down-Regulation of Akt

2006 • 152 citations

Diabetes Alters the Expression and Activity of the Human Placental GLUT1 Glucose Transporter¹

1999 • 149 citations

Activation of Nuclear Factor-κB by High Molecular Weight and Globular Adiponectin

2007 • 147 citations

Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells

2009 • 142 citations

Regulation of placental amino acid transporter activity by mammalian target of rapamycin

2008 • 139 citations

Cardiac-Specific Overexpression of Peroxisome Proliferator–Activated Receptor-α Causes Insulin Resistance in Heart and Liver

2005 • 115 citations

Hypoxia reduces expression and function of system A amino acid transporters in cultured term human trophoblasts

2003 • 111 citations

Amino acid transport by the cultured human placental trophoblast: effect of insulin on AIB transport

1992 • 110 citations

Deficiency of Adiponectin Receptor 2 Reduces Diet-Induced Insulin Resistance but Promotes Type 2 Diabetes

2006 • 110 citations

Use of Akt Inhibitor and a Drug-resistant Mutant Validates a Critical Role for Protein Kinase B/Akt in the Insulin-dependent Regulation of Glucose and System A Amino Acid Uptake

2008 • 110 citations

Diabetes Alters the Expression and Activity of the Human Placental GLUT1 Glucose Transporter

1999 • 107 citations

Peroxisome Proliferators‐Activated Receptor (PPAR) Modulators and Metabolic Disorders

2008 • 84 citations

Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts

2005 • 77 citations

Expression and regulation of 4F2hc and hLAT1 in human trophoblasts

2002 • 74 citations

Adiponectin Attenuation of Endocrine Function within Human Term Trophoblast Cells

2009 • 56 citations

Changes in placental adipocytokine gene expression associated with gestational diabetes mellitus

2006 • 53 citations

Adiponectin-induced secretion of interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1, CCL2) and interleukin-8 (IL-8, CXCL8) is impaired in monocytes from patients with type I diabetes

2006 • 52 citations

Amino Acid Transporter ATA2 Is Stored at the trans-Golgi Network and Released by Insulin Stimulus in Adipocytes

2006 • 51 citations

High Molecular Mass Multimer Complexes and Vascular Expression Contribute to High Adiponectin in the Fetus

2008 • 46 citations

Adiponectin induces interleukin‐6 production and activates STAT3 in adult mouse cardiac fibroblasts

2008 • 36 citations

Characterization and regulation of the gene expression of amino acid transport system A (SNAT2) in rat mammary gland

2006 • 29 citations

Oleoylethanolamide, a natural ligand for PPAR-alpha, inhibits insulin receptor signalling in HTC rat hepatoma cells

2009 • 26 citations

Insulin Stimulates Synthesis and Release of Human Chorionic Gonadotropin by Choriocarcinoma Cell Lines

1991 • 22 citations

Oleic acid inhibits hepatic insulin signaling through deregulation of STAT3 activation and C/EBPα expression

2009 • 13 citations

Reappraisal of neonatal clavicular fracture. Relationship between infant size and risk factors.

2002 • 12 citations

Effects of Glucose, Glycerol, 3-Hydroxybutyrate, Insulin, and Leptin on Placental Growth Hormone Secretion in Placental Explants

2008 • 9 citations

An Attempt to Observe the Absorption of Neutrinos

1939 • 9 citations