Inhibition of cell death by lens-specific overexpression of bcl-2 in transgenic mice

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

1991 • 915 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

Lens Differentiation in Vertebrates

1981 • 638 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

FVB/N: an inbred mouse strain preferable for transgenic analyses.

1991 • 600 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1993 • 586 citations

bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis.

1995 • 578 citations

THE TUMOR SUPPRESSOR GENES

1993 • 509 citations

STRUCTURE AND FUNCTION OF SIMIAN VIRUS 40 LARGE TUMOR ANTIGEN

1992 • 506 citations

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.

1988 • 499 citations

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

1993 • 476 citations

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

1991 • 464 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.

1989 • 383 citations

Bcl-2 blocks p53-dependent apoptosis.

1994 • 371 citations

Ultrastructural localization of bcl-2 protein.

1992 • 351 citations

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.

1994 • 310 citations

Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice.

1985 • 242 citations

Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development.

1995 • 234 citations

Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice

1995 • 222 citations

bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations.

1996 • 212 citations

Oncogenesis of the Lens in Transgenic Mice

1987 • 202 citations

A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization.

1992 • 193 citations

Cell division, cell elongation and distribution of α-, β- and γ-crystallins in the rat lens

1978 • 185 citations

Expression of a truncated FGF receptor results in defective lens development in transgenic mice

1995 • 176 citations

BCL-2 expression in human colorectal adenomas and carcinomas.

1994 • 168 citations

bcl-2 in cancer, development and apoptosis

1994 • 128 citations

Life and death by P53

1995 • 111 citations

The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice.

1994 • 104 citations

Human gliomas with wild-type p53 express bcl-2.

1995 • 94 citations

Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration.

1996 • 80 citations

Evidence that p53 and bcl-2 are regulators of a common cell death pathway important for in vivo lymphomagenesis.

1994 • 67 citations

Regulation of cyclin and cyclin-dependent kinase gene expression during lens differentiation requires the retinoblastoma protein.

1996 • 54 citations

Bcl-2 regulates activation of apoptotic proteases in a cell-free system

1996 • 49 citations