bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations.

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light.

1992 • 703 citations

Apoptosis: Final common pathway of photoreceptor death in rd, rds, and mutant mice

1993 • 653 citations

Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.

1994 • 630 citations

Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse.

1991 • 558 citations

Differential effect of the rd mutation on rods and cones in the mouse retina.

1978 • 493 citations

Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat

1992 • 355 citations

A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment

1994 • 338 citations

Influence of eye pigmentation and light deprivation on inherited retinal dystrophy in the rat

1975 • 330 citations

Mechanisms of Rhodopsin Inactivation in Vivo as Revealed by a COOH-Terminal Truncation Mutant

1995 • 299 citations

Molecular genetics of retinitis pigmentosa

1995 • 255 citations

Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats.

1994 • 214 citations

Linkage of photoreceptor degeneration by apoptosis with inherited defect in phototransduction.

1994 • 195 citations

Mammalian rod terminal: Architecture of a binary synapse

1995 • 181 citations

Tissue-specific and developmental regulation of rod opsin chimeric genes in transgenic mice

1991 • 177 citations

Degenerative changes in a retina affected with autosomal dominant retinitis pigmentosa.

1989 • 152 citations

Autosomal Dominant Retinitis Pigmentosa Caused by the Threonine-17-Methionine Rhodopsin Mutation: Retinal Histopathology and Immunocytochemistry

1994 • 146 citations

Genetic regulation of light damage to photoreceptors.

1987 • 144 citations

bcl‐2, a novel reguator of cell death

1995 • 128 citations

Degenerative retinal disorders: Clinical and laboratory investigations

1988 • 126 citations

Degenerative Diseases of the Retina

1995 • 92 citations

Progress in retinal and eye research

1994 • 86 citations

Bcl-2 proto-oncogene protein immunoreactivity in normally developing and axotomised rat retinas

1994 • 52 citations

Downregulation of cGMP phosphodiesterase induced by expression of GTPase-deficient cone transducin in mouse rod photoreceptors.

1994 • 35 citations

Rhodopsin mutation proline³⁴⁷-to-alanine in a family with autosomal dominant retinitis pigmentosa indicates an important role for proline at position 347

1995 • 21 citations