Historical Development of the Concept of the Gene

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

A new method for sequencing DNA.

1977 • 7,941 citations

The Genome Sequence of Drosophila melanogaster

2000 • 5,882 citations

Life with 6000 Genes

1996 • 4,125 citations

STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES

1944 • 3,183 citations

Repeated Sequences in DNA

1968 • 2,836 citations

Nucleotide sequence of bacteriophage G4 DNA

1978 • 2,137 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

Construction of Biologically Functional Bacterial Plasmids In Vitro

1973 • 1,699 citations

Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

1981 • 1,677 citations

Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose-ethidium bromide electrophoresis

1973 • 1,616 citations

INDEPENDENT FUNCTIONS OF VIRAL PROTEIN AND NUCLEIC ACID IN GROWTH OF BACTERIOPHAGE

1952 • 1,520 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

The DNA sequence of human chromosome 21

2000 • 1,406 citations

Genetic Control of Biochemical Reactions in Neurospora

1941 • 1,310 citations

The DNA sequence of human chromosome 22

1999 • 1,167 citations

An Unstable Intermediate Carrying Information from Genes to Ribosomes for Protein Synthesis

1961 • 1,108 citations

The neurofibromatosis type 1 gene encodes a protein related to GAP

1990 • 1,099 citations

Complete nucleotide sequence of SV40 DNA

1978 • 1,050 citations

Visualization of Nucleolar Genes

1969 • 865 citations

A Restriction enzyme from Hemophilus influenzae

1970 • 859 citations

Elemente der exakten Erblichkeitslehre

1909 • 807 citations

The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants

1981 • 776 citations

Factors of Evolution:. The Theory of Stabilizing Selection

1950 • 773 citations

Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types

2017 • 770 citations

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

1976 • 726 citations

Biochemical Method for Inserting New Genetic Information into DNA of Simian Virus 40: Circular SV40 DNA Molecules Containing Lambda Phage Genes and the Galactose Operon of Escherichia coli

1972 • 723 citations

The linear arrangement of six sex‐linked factors in Drosophila, as shown by their mode of association

1913 • 705 citations

THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION

1955 • 700 citations

SALIVARY CHROMOSOME MAPS

1935 • 682 citations

Adaptation and Environment

2014 • 677 citations

ON THE TOPOGRAPHY OF THE GENETIC FINE STRUCTURE

1961 • 576 citations

Sequence of the human insulin gene

1980 • 553 citations

NON-DISJUNCTION AS PROOF OF THE CHROMOSOME THEORY OF HEREDITY

1916 • 542 citations

FINE STRUCTURE OF A GENETIC REGION IN BACTERIOPHAGE

1955 • 524 citations

Enhancers and eukaryotic gene transcription

1985 • 515 citations

The structure and evolution of the two nonallelic rat preproinsulin genes

1979 • 500 citations

POLYPROTEIN GENE EXPRESSION: Generation of Diversity of Neuroendocrine Peptides

1984 • 497 citations

COMPLEX TRANSCRIPTIONAL UNITS: DIVERSITY IN GENE EXPRESSION BY ALTERNATIVE RNA PROCESSING

1986 • 486 citations

Steps in the processing of Ad2 mRNA: Poly(A)+ Nuclear sequences are conserved and poly(A) addition precedes splicing

1978 • 478 citations

A restriction enzyme from Hemophilus influenzae: II. Base sequence of the recognition site

1970 • 455 citations

Comparison of the Complete Protein Sets of Worm and Yeast: Orthology and Divergence

1998 • 447 citations

The population dynamics of transposable elements

1983 • 438 citations

The rabbit β-globin gene contains a large insert in the coding sequence

1977 • 422 citations

The messenger RNA for alcohol dehydrogenase in Drosophila melanogaster differs in its 5′ end in different developmental stages

1983 • 415 citations

Mutable Loci in Maize

1948 • 412 citations

Expressing the human genome

2001 • 407 citations

A single mouse α-amylase gene specifies two different tissue-specific mRNAs

1981 • 402 citations

ON THE TOPOLOGY OF THE GENETIC FINE STRUCTURE

1959 • 396 citations

Ovalbumin gene is split in chicken DNA

1977 • 396 citations

Possible Relation between Deoxyribonucleic Acid and Protein Structures

1954 • 382 citations

THE CHROMOSOMES IN HEREDITY

1903 • 381 citations

Histone Genes and Histone Messengers

1979 • 373 citations

Co-Linearity of the Gene with the Polypeptide Chain

1964 • 368 citations

The Mechanism of Mendelian Heredity

1916 • 365 citations

Phosphorus incorporation in Escherichia coli ribonucleic acid after infection with bacteriophage T2

1956 • 335 citations

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

1979 • 329 citations

Enzymatic end-to-end joining of DNA molecules

1973 • 311 citations

A pseudogene structure in 5S DNA of Xenopus laevis

1977 • 296 citations

Nucleotide Sequence Repetition: A Rapidly Reassociating Fraction of Mouse DNA

1966 • 288 citations

Involvement of RNA in the Synthesis of Proteins

1963 • 267 citations

The collagen gene: Evidence for its evolutionary assembly by amplification of a DNA segment containing an exon of 54 bp

1980 • 260 citations

ON THE COLINEARITY OF GENE STRUCTURE AND PROTEIN STRUCTURE

1964 • 254 citations

Gene within a gene: Nested Drosophila genes encode unrelated proteins on opposite DNA strands

1986 • 251 citations

A REVISED MAP OF THE SALIVARY GLAND X-CHROMOSOME of Drosophila Melanogaster

1938 • 216 citations

ALTERNATIVE PROMOTERS IN DEVELOPMENTAL GENE EXPRESSION

1987 • 204 citations

Organization of the rat γ-fibrinogen gene: Alternative mRNA splice patterns produce the γA and γB (γ′) chains of fibrinogen

1982 • 201 citations

ON THE SEPARATION OF THE TRYPTOPHAN SYNTHETASE OF ESCHERICHIA COLI INTO TWO PROTEIN COMPONENTS

1958 • 197 citations

The elementary units of heredity.

1956 • 190 citations

A mouse locus at which transcription from both DNA strands produces mRNAs complementary at their 3′ ends

1986 • 187 citations

A transcribed gene in an intron of the human factor VIII gene

1990 • 182 citations

HOST SPECIFICITY OF DNA PRODUCED BY Escherichia coli , XI. In vitro MODIFICATION OF PHAGE FD REPLICATIVE FORM

1969 • 178 citations

THE ORNITHINE CYCLE IN NEUROSPORA AND ITS GENETIC CONTROL

1944 • 176 citations

Generation of Protein Isoform Diversity by Alternative Splicing: Mechanistic and Biological Implications

1987 • 163 citations

Purification and Some Characteristics of 5S DNA from Xenopus laevis

1971 • 162 citations

Genes Made Molecular

1994 • 160 citations

Cytogenetic Studies of Maize and Neurospora

1945 • 159 citations

Overlapping transcription units in the dopa decarboxylase region of Drosophila

1986 • 158 citations

A novel mechanism of alternative RNA splicing for the developmentally regulated generation of troponin T isoforms from a single gene

1984 • 157 citations

NUCLEIC ACID ECONOMY IN BACTERIA INFECTED WITH BACTERIOPHAGE T2

1953 • 145 citations

[Duplicating mechanism for peptide chain and nucleic acid synthesis].

1952 • 145 citations

The linear arrangement of a series of alleles of Aspergillus nidulans

1955 • 144 citations

Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms

1981 • 143 citations

A NEW METHOD FOR THE STUDY OF CHROMOSOME ABERRATIONS AND THE PLOTTING OF CHROMOSOME MAPS IN DROSOPHILA MELANOGASTER

1934 • 139 citations

Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions.

1979 • 131 citations

STUDIES ON THE MECHANISM OF REVERSION IN BIOCHEMICAL MUTANTS OF NEUROSPORA CRASSA

1951 • 125 citations

Molecular and Biological Characterization of Messenger RNA

1961 • 123 citations

What Exactly Are Genomes, Genotypes and Phenotypes? And What About Phenomes?

1997 • 121 citations

IN VITRO TRANSFORMATION OF PNEUMOCOCCAL TYPES

1931 • 121 citations

Genes Coding for Polysomal 9S RNA of Sea Urchins: Conservation and Divergence

1972 • 114 citations

Alternatives for splicing: Recognizing the ends of introns

1980 • 113 citations

Multiple 5′ terminal cap structures in late polyoma virus RNA

1979 • 105 citations

On the expression of a structural gene

1960 • 104 citations

THE TRANSFORMATION IN VITRO OF R PNEUMOCOCCI INTO S FORMS OF DIFFERENT SPECIFIC TYPES BY THE USE OF FILTERED PNEUMOCOCCUS EXTRACTS

1932 • 103 citations

Control of messenger RNA concentration by differential cytoplasmic half-life

1981 • 101 citations

Portrait of a gene

1969 • 99 citations

The molecular conservation of ribonucleic acid during bacterial growth

1960 • 98 citations

Crossing-Over Between Alleles at the Lozenge Locus in Drosophila Melanogaster

1949 • 96 citations

At least two genes reside within a large intron of the dunce gene of Drosophila

1987 • 96 citations

Alternative Splicing of a Drosophila Tropomyosin Gene Generates Muscle Tropomyosin Isoforms with Different Carboxy-Terminal Ends

1984 • 91 citations

Neuropeptides: Mediators of Behavior in Aplysia

1984 • 84 citations

THE COMPLETE AMINO ACID SEQUENCE OF THE TRYPTOPHAN SYNTHETASE A PROTEIN (α SUBUNIT) AND ITS COLINEAR RELATIONSHIP WITH THE GENETIC MAP OF THE A GENE

1967 • 84 citations

Extrachromosomal nucleolar genes in amphibian oocytes.

1969 • 79 citations

Genes and Genomes: A Changing Perspective

1990 • 76 citations

Molecular Genetics: An Introductory Narrative

1971 • 75 citations

Gene K, a new overlapping gene in bacteriophage G4

1978 • 75 citations

Transposable Genetic Elements

1980 • 67 citations

G. Mendel’s Regel über das Verhalten der Nachkommenschaft der Rassenbastarde

1924 • 67 citations

Expression of three mRNA species from a single rat aldolase A gene, differing in their 5′ non-coding regions

1986 • 66 citations

Metabolism of RNA phosphorus in Escherichia coli infected with bacteriophage T7

1958 • 63 citations

The Cytological Expression of Changes in Gene Alignment Produced by X-Rays in Drosophila

1929 • 60 citations

Distribution of transposable elements in Drosophila species.

1999 • 57 citations

A REVERSION TO WILD-TYPE ASSOCIATED WITH CROSSING-OVER IN DROSOPHILA MELANOGASTER

1940 • 53 citations

Many protein products from a few loci: assignment of human salivary proline-rich proteins to specific loci.

1988 • 50 citations

Transposable Genetic Elements in Maize

1984 • 46 citations

On Conceptual Change in Biology: The Case of the Gene

2004 • 45 citations

Genotype and Phenotype

2015 • 43 citations

Search for Linkage between Genes determining a Vitamin Requirement

1950 • 43 citations

THE METABOLISM OF RIBONUCLEIC ACID IN NORMAL AND BACTERIOPHAGE INFECTED ESCHERICHIA COLI

1953 • 41 citations

In vivo developmental modifications of the expression of genes encoding muscle-specific enzymes in rat.

1986 • 39 citations

Correspondences Between Linkage Maps and Salivary Chromosome Structure, as Illustrated in the Tip of Chromosome 2R of <i>Drosophila melanogaster</i>

1937 • 37 citations

Organization of Immunoglobulin Genes

1978 • 37 citations

Another Case of Unequal Crossing-Over in Drosophila Melanogaster

1941 • 33 citations

Polyoma infected cells contain at least three spliced late RNA s

1978 • 29 citations

The Drosophila genome project: a progress report

1998 • 27 citations

Sometimes an editor makes sense

1990 • 26 citations

THE FUNCTION OF RNA IN T2-INFECTED BACTERIA

1960 • 25 citations

Über die Konstitution der chromatischen Kernsubstanz

1903 • 17 citations

Glossary of genetics: Classical and molecular (5th ed.)

1991 • 12 citations

The Gene: Its Structure, Function, and Evolution

1987 • 11 citations

The Q locus of Neurospora.

1950 • 9 citations

Overlapping transcription units in Drosophila: Sequence and structure of the Cs gene

1987 • 8 citations

Displacement Loops in Adenovirus DNA-RNA Hybrids

1978 • 5 citations

Properties of genes

1965 • 4 citations

Identification of an alternative open reading frame ("hidden gene"?) stringently required for infectivity of poliovirus cDNA clones.

1998 • 3 citations