ALTERNATIVE PROMOTERS IN DEVELOPMENTAL GENE EXPRESSION

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

REGULATORY SEQUENCES INVOLVED IN THE PROMOTION AND TERMINATION OF RNA TRANSCRIPTION

1979 • 2,730 citations

Compilation and analysis ofEscherichia colipromoter DNA sequences

1983 • 2,228 citations

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

1981 • 1,611 citations

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

Tissue-specific in vitro transcription from the mouse albumin promoter

1986 • 1,322 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication

1987 • 1,050 citations

Evidence for two functional gal promoters in intact Escherichia coli cells.

1981 • 1,022 citations

Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40

1987 • 762 citations

Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA

1986 • 722 citations

Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins

1984 • 686 citations

Cyclic AMP Receptor Protein: Role in Transcription Activation

1984 • 645 citations

Genetic Switch

2008 • 590 citations

Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster

1986 • 587 citations

Genetic Regulation: The Lac Control Region

1975 • 523 citations

A molecular gradient in early Drosophila embryos and its role in specifying the body pattern

1986 • 504 citations

Eukaryotic Nuclear RNA Polymerases

1975 • 491 citations

MUTANTS OF YEAST DEFECTIVE IN SUCROSE UTILIZATION

1981 • 476 citations

A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.

1984 • 424 citations

A glimpse at chromosomal order

1987 • 423 citations

The messenger RNA for alcohol dehydrogenase in Drosophila melanogaster differs in its 5′ end in different developmental stages

1983 • 415 citations

A single mouse α-amylase gene specifies two different tissue-specific mRNAs

1981 • 402 citations

Alternative transcription and two modes of splicing result in two myosin light chains from one gene

1984 • 400 citations

Cell-type-specific contacts to immunoglobulin enhancers in nuclei

1985 • 341 citations

Promoters of Escherichia coli: a hierarchy of in vivo strength indicates alternate structures.

1986 • 305 citations

Bacteriophage T7 early promoters: Nucleotide sequences of two RNA polymerase binding sites

1975 • 303 citations

DNA determinants of rRNA synthesis in E. coli: Growth rate dependent regulation, feedback inhibition, upstream activation, antitermination

1986 • 300 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

A single locus in the mouse encodes both myosin light chains 1 and 3, a second locus corresponds to a related pseudogene

1984 • 256 citations

THE REGULATION OF TRANSCRIPTION INITIATION IN BACTERIA

1985 • 251 citations

Spacing of the -10 and -35 regions in the tac promoter. Effect on its in vivo activity.

1985 • 245 citations

Purified λ regulatory protein cII positively activates promoters for lysogenic development

1981 • 241 citations

Dual control for transcription of the galactose operon by cyclic AMP and its receptor protein at two interspersed promoters

1977 • 239 citations

Control of λ Repressor Synthesis

1971 • 219 citations

Two RNA polymerase sigma factors from Bacillus subtilis discriminate between overlapping promoters for a developmentally regulated gene

1983 • 218 citations

Nucleotide sequence of an RNA polymerase binding site from the DNA of bacteriophage fd.

1975 • 209 citations

Tissue‐specific expression of porphobilinogen deaminase

1987 • 209 citations

A control element within a structural gene: The gal operon of Escherichia coli

1983 • 206 citations

Tissue-specific expression of mouse α-amylase genes

1980 • 198 citations

Rat insulin-like growth factor II gene

1986 • 192 citations

Duplicated heavy metal control sequences of the mouse metallothionein-I gene.

1984 • 167 citations

The uvrB gene of Escherichia coli has both lexA-repressed and lexA-independent promoters

1982 • 140 citations

Sequences of cDNAs for human salivary and pancreatic α-amylases

1984 • 140 citations

Tandem promoters direct E. coli ribosomal RNA synthesis

1979 • 137 citations

Demonstration of two operator elements in gal: in vitro repressor binding studies.

1984 • 130 citations

The expression of the gene coding for alcohol dehydrogenase during the development of Drosophila melanogaster

1986 • 126 citations

Translationsl regulation of expression of the bacteriophage T4 lysozyme gene

1986 • 122 citations

Evidence against a scanning model of RNA splicing.

1983 • 122 citations

In Vitro Transcription of the Gal Operon Requires Cyclic Adenosine Monophosphate and Cyclic Adenosine Monophosphate Receptor Protein

1971 • 117 citations

Tandem promoters determine regulation of theKlebsiella pneumoniaeglutamine synthetase (glnA) gene

1984 • 116 citations

Ontogeny and tissue distribution of alcohol dehydrogenase inDrosophila melanogaster

1970 • 111 citations

GENETICS OF AMYLASE ISOZYMES IN THE MOUSE

2009 • 106 citations

Long-range cooperativity between gene regulatory sequences in a prokaryote

1987 • 106 citations

Cell-type-specific transcription of an immunoglobulin kappa light chain gene in vitro.

1986 • 96 citations

An inversion that disrupts the Antennapedia gene causes abnormal structure and localization of RNAs

1986 • 96 citations

Comparison of promoter suppression in avian and murine retrovirus vectors

1986 • 95 citations

Identification of initiation sites for the in vitro transcription of rRNA operons rrnE and rrnA in E. coli

1979 • 91 citations

Mutations in the Escherichia coli operon that define two promoters and the binding site of the cyclic AMP receptor protein

1982 • 89 citations

Isolation of mutant promoters in the Escherichia coli galactose operon using local mutagenesis on cloned DNA fragments

1982 • 81 citations

Repressor and Cro Protein: Structure, Function, and Role in Lysogenization

1983 • 79 citations

Alternative 5′ exons either provide or deny an initiator methionine codon to the same α-tubulin coding region

1987 • 57 citations

The nucleotide sequence surrounding the promoter region of colicin E1 gene

1981 • 54 citations

Cloned Drosophila alcohol dehydrogenase genes are correctly expressed after transfection into Drosophila cells in culture.

1984 • 47 citations

In vivo developmental modifications of the expression of genes encoding muscle-specific enzymes in rat.

1986 • 39 citations

Electrophoretic Variation of α-Amylase in Two Inbred Strains of Mus musculus

1973 • 33 citations

Regulation of the expression of bacteriophage T4 genes 32 and 43

1977 • 32 citations

A Simple Gene with a Complex Pattern of Transcription: The Alcohol Dehydrogenase Gene of Drosophila melanogaster

1985 • 28 citations

Pancreatic Amylase Expression in Human Pancreatic Development

1986 • 19 citations

Mouse alpha-amylase loci, Amy-1a and Amy-2a, are closely linked

1985 • 18 citations

A U-turn in the regulation of transcription?

1986 • 8 citations