Local anesthetics and histrionicotoxin are allosteric inhibitors of the acetylcholine receptor. Studies of clonal muscle cells.

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

1978 • 864 citations

The Combinations of Haemoglobin with Oxygen and with Carbon Monoxide. I

1913 • 777 citations

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

1980 • 608 citations

On the application of “a plausible model” of allosteric proteins to the receptor for acetylcholine

1967 • 425 citations

The Cell surface and neuronal function

1980 • 379 citations

Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels

1981 • 366 citations

On the nature of allosteric transitions: Implications of non-exclusive ligand binding

1966 • 336 citations

In Vitro excitation of purified membrane fragments by cholinergic agonists

1971 • 250 citations

Isolation of the Principal Neurotoxins of Two Naja naja Subspecies

1971 • 248 citations

Functional consequences of agonist-mediated state transitions in the cholinergic receptor. Studies in cultured muscle cells.

1979 • 191 citations

Fast Kinetic Studies on the Interaction of a Fluorescent Agonist with the Membrane‐Bound Acetylcholine Receptor from Torpedo marmorata

1979 • 183 citations

Dependence of acetylcholine desensitization on the membrane potential of frog muscle fibre and on the ionic changes in the medium

1970 • 172 citations

Permeability control by cholinergic receptors in Torpedo postsynaptic membranes: agonist dose-response relations measured at second and millisecond times

1980 • 170 citations

A quantitative analysis of local anaesthetic alteration of miniature end‐plate currents and end‐plate current fluctuations.

1977 • 169 citations

Affinity labeling of one of two α-neurotoxin binding sites in acetylcholine receptor from Torpedo californica

1978 • 163 citations

Acetylcholine receptor metabolism in a nonfusing muscle cell line.

1977 • 160 citations

Relationship between reversible antagonist occupancy and the functional capacity of the acetylcholine receptor.

1981 • 158 citations

Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. II. Effect of cholinergic agonists and antagonists on the binding of the tritiated alpha-neurotoxin.

1974 • 148 citations

Alteration by Xylocaine (Lidocaine) and Its Derivatives of the Time Course of the End Plate Potential

1968 • 143 citations

Kinetics of agonist-mediated transitions in state of the cholinergic receptor.

1977 • 143 citations

Molecular Mechanisms of Anesthesia

1981 • 140 citations

The relationship between agonist occupation and the permeability response of the cholinergic receptor revealed by bound cobra alpha-toxin.

1980 • 140 citations

Acetylcholine Receptor and Ion Conductance Modulator Sites at the Murine Neuromuscular Junction: Evidence from Specific Toxin Reactions

1973 • 133 citations

Identification of a local anesthetic binding site in nicotinic post-synaptic membranes isolated from Torpedo marmorata electric tissue.

1979 • 120 citations

Ligand-induced conformation changes in Torpedo californica membrane-bound acetylcholine receptor

1978 • 119 citations

Conditions for the selective labelling of the 66 000 dalton chain of the acetylcholine receptor by the covalent non‐competitive blocker 5‐azido‐[³H]trimethisoquin

1980 • 111 citations

Stoichiometry of the Ligand-Binding Sites in the Acetylcholine-Receptor Oligomer from Muscle and from Electric Organ. Measurement by Affinity Alkylation with Bromoacetylcholine

1980 • 110 citations

Effects of local anesthetics and calcium on the interaction of cholinergic ligands with the nicotinic receptor protein from Torpedo marmorata.

1974 • 108 citations

Agonist-mediated changes of the acetylcholine receptor in its membrane environment

1978 • 104 citations

Ligand interactions with cholinergic receptor-enriched membranes from Torpedo: influence of agonist exposure on receptor properties.

1976 • 102 citations

Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ

1976 • 92 citations

Ligand specificity of state transitions in the cholinergic receptor: behavior of agonists and antagonists.

1979 • 89 citations

Regulation of [3H]perhydrohistrionicotoxin binding to Torpedo ocellata electroplax by effectors of the acetylcholine receptor.

1981 • 83 citations

Studies on the effect of histrionicotoxin on the monocellular electroplax from Electrophorus electricus and on the binding of (3H)acetylcholine to membrane fragments from Torpedo marmorata.

1976 • 65 citations

Mechanism of inactivation (desensitization) of acetylcholine receptor. Investigations by fast reaction techniques with membrane vesicles

1981 • 60 citations

Binding of perhydrohistrionicotoxin to intact and detergent-solubilized membranes enriched in nicotinic acetylcholine receptor

1979 • 58 citations

Histrionicotoxin enhances agonist-induced desensitization of acetylcholine receptor.

1977 • 53 citations

Voltage-dependent and voltage-independent blockade of acetylcholine receptors by local anesthetics in Electrophorus electroplaques.

1979 • 51 citations

INFLUENCE OF SKF‐525A CONGENERS, STROPHANTHIDIN AND TISSUE‐CULTURE MEDIA ON DESENSITIZATION IN FROG SKELETAL MUSCLE

1974 • 33 citations