Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling

Why do cancers have high aerobic glycolysis?

2004 • 4,534 citations

Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery

2000 • 2,450 citations

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

2003 • 1,184 citations

Activity-Based Protein Profiling in Vivo Using a Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition

2003 • 919 citations

Profiling Enzyme Activities In Vivo Using Click Chemistry Methods

2004 • 738 citations

Glycolytic Enzymes Can Modulate Cellular Life Span

2005 • 615 citations

Exploring biology with small organic molecules

2004 • 459 citations

Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin

1998 • 431 citations

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

2003 • 374 citations

From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes

2003 • 262 citations

Protein‐Reactive Natural Products

2005 • 240 citations

Mechanistic Basis of Enzyme-Targeted Drugs

2005 • 238 citations

Small Molecules that Induce Cardiomyogenesis in Embryonic Stem Cells

2004 • 228 citations

Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs

2000 • 221 citations

New Antitumor Substances, FR901463, FR901464 and FR901465. II. Activities against Experimental Tumors in Mice and Mechanism of Action.

1996 • 206 citations

Target Identification in Chemical Genetics

2004 • 191 citations

A Tandem Orthogonal Proteolysis Strategy for High-Content Chemical Proteomics

2005 • 188 citations

New Antitumor Substances, FR901463, FR901464 and FR901465. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities.

1996 • 174 citations

Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex

2001 • 126 citations

A Genome-Wide Overexpression Screen in Yeast for Small-Molecule Target Identification

2005 • 112 citations

Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex

2001 • 105 citations

Complex phenotypic assays in high-throughput screening

2004 • 99 citations

Identification of an essential carboxylate group at the active site of lacZβ‐galactosidase from Escherichia coli

1984 • 83 citations

Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations

2004 • 72 citations

Assessment of chemical libraries for their druggability

2005 • 65 citations

Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor

2005 • 64 citations

Phosphoglycerate Mutase-derived Polypeptide Inhibits Glycolytic Flux and Induces Cell Growth Arrest in Tumor Cell Lines

2004 • 62 citations

Development of a mutagenesis, expression and purification system for yeast phosphoglycerate mutase

1992 • 54 citations

Crystal structure of human B-type phosphoglycerate mutase bound with citrate

2005 • 31 citations

How to starve a tumor

1997 • 30 citations

Luminacins. A Family of Capillary Tube Formation Inhibitors from Streptomyces sp. II. Biological Activities.

2000 • 26 citations

Polyanionic Inhibitors of Phosphoglycerate Mutase: Combined Structural and Biochemical Analysis

1999 • 25 citations

Luminacins. A Family of Capillary Tube Formation Inhibitors from Streptomyces sp. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Elucidation.

2000 • 20 citations