How to starve a tumor

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

1996 • 1,769 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

1997 • 622 citations

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1995 • 603 citations

Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor

1993 • 578 citations

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

1995 • 483 citations

Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin

1997 • 416 citations

On the Mechanism of Asymmetric Nucleophilic Ring-Opening of Epoxides Catalyzed by (Salen)Cr^III Complexes

1996 • 381 citations

Structure of the cobalt-dependent methionine aminopeptidase from Escherichia coli: a new type of proteolytic enzyme

1993 • 326 citations

Amino-terminal protein processing in Saccharomyces cerevisiae is an essential function that requires two distinct methionine aminopeptidases.

1995 • 284 citations

Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes.

1995 • 249 citations

Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins

1996 • 217 citations

Disruption of the Yeast N -Myristoyl Transferase Gene Causes Recessive Lethality

1989 • 190 citations

Molecular Cloning of a Murine cDNA Encoding a Novel Protein, p38-2G4, Which Varies with the Cell Cycle

1995 • 105 citations

Irreversible Inhibition of the HIV-1 Protease: Targeting Alkylating Agents to the Catalytic Aspartate Groups

1996 • 28 citations

Mechanism of cysteine protease inactivation by peptidyl epoxides

1997 • 24 citations