A Genome-Wide Overexpression Screen in Yeast for Small-Molecule Target Identification

Functional profiling of the Saccharomyces cerevisiae genome

2002 • 4,348 citations

Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

1999 • 3,929 citations

Functional Discovery via a Compendium of Expression Profiles

2000 • 2,581 citations

Guide to Yeast Genetics and Molecular Biology

1993 • 2,377 citations

Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants

2001 • 2,139 citations

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase

2000 • 1,770 citations

Clinical, Cellular, and Molecular Factors That Contribute to Antifungal Drug Resistance

1998 • 1,360 citations

Integrating Genetic Approaches into the Discovery of Anticancer Drugs

1997 • 757 citations

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

2003 • 674 citations

Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth.

1994 • 616 citations

Guide to Yeast Genetics and Molecular Biology

1991 • 607 citations

Genomic profiling of drug sensitivities via induced haploinsufficiency

1999 • 568 citations

Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast

2004 • 503 citations

Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes

2004 • 477 citations

Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect.

1992 • 371 citations

The protein kinase C‐mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae

1999 • 325 citations

MKK1 and MKK2, Which Encode Saccharomyces cerevisiae Mitogen-Activated Protein Kinase-Kinase Homologs, Function in the Pathway Mediated by Protein Kinase C

1993 • 306 citations

The art and design of genetic screens: yeast

2001 • 272 citations

Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous- growth signalling pathway

1997 • 270 citations

Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity.

1996 • 266 citations

Targeted selection of recombinant clones through gene dosage effects.

1983 • 262 citations

SBF Cell Cycle Regulator as a Target of the Yeast PKC-MAP Kinase Pathway

1997 • 247 citations

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors

2000 • 232 citations

A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator

1997 • 227 citations

Human genetic diseases: a cross-talk between man and yeast

1997 • 214 citations

DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray

2003 • 200 citations

A Family of Cyclin-Like Proteins That Interact with the Pho85 Cyclin-Dependent Kinase

1997 • 199 citations

Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants

1999 • 193 citations

MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C.

1993 • 187 citations

The PCL2 (ORFD)-PHO85 Cyclin-Dependent Kinase Complex: a Cell Cycle Regulator in Yeast

1994 • 164 citations

A Combinatorial Scaffold Approach toward Kinase-Directed Heterocycle Libraries

2002 • 163 citations

The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane

2003 • 155 citations

Cell Cycle Control by a Complex of the Cyclin HCS26 (PCL1) and the Kinase PHO85

1994 • 152 citations

CDK inhibition and cancer therapy

1999 • 149 citations

Transcriptional Coregulation by the Cell Integrity Mitogen-Activated Protein Kinase Slt2 and the Cell Cycle Regulator Swi4

2001 • 121 citations

Identification of the yeast ACC1 gene product (acetyl-CoA carboxylase) as the target of the polyketide fungicide soraphen A

1994 • 105 citations

Yeast and drug discovery

2002 • 102 citations

The G₁ Cyclin Cln3 Promotes Cell Cycle Entry via the Transcription Factor Swi6

2002 • 87 citations

A pathway in the yeast cell division cycle linking protein kinase C (Pkc1) to activation of Cdc28 at START.

1996 • 75 citations

Protein kinases as therapeutic targets.

2000 • 74 citations

Genetic Evidence for a Morphogenetic Function of the Saccharomyces cerevisiae Pho85 Cyclin-Dependent Kinase

2001 • 52 citations

Cancer therapeutics in yeast

2002 • 51 citations

Yeast genomics and proteomics in drug discovery and target validation.

2003 • 50 citations

Fus3p and Kss1p Control G1 Arrest in Saccharomyces cerevisiae Through a Balance of Distinct Arrest and Proliferative Functions That Operate in Parallel With Far1p

1999 • 49 citations

Chemical and Biological Profile of Dual Cdk1 and Cdk2 Inhibitors

2003 • 36 citations

Drug-induced phenotypes provide a tool for the functional analysis of yeast genes

1998 • 31 citations