M100907, a Serotonin 5-HT2A Receptor Antagonist and Putative Antipsychotic, Blocks Dizocilpine-Induced Prepulse Inhibition Deficits in Sprague–Dawley and Wistar Rats

Prestimulus Effects on Human Startle Reflex in Normals and Schizophrenics

1978 • 1,173 citations

Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

1996 • 1,143 citations

Gating and Habituation of the Startle Reflex in Schizophrenic Patients

1992 • 1,030 citations

Reflex modification in the domain of startle: I. Some empirical findings and their implications for how the nervous system processes sensory input.

1980 • 783 citations

Assessing the Validity of an Animal Model of Deficient Sensorimotor Gating in Schizophrenic Patients

1994 • 702 citations

Dopaminergic stimulation disrupts sensorimotor gating in the rat

1988 • 609 citations

Startle response models of sensorimotor gating and habituation deficits in schizophrenia

1990 • 457 citations

Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.

1996 • 342 citations

Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response.

1994 • 334 citations

Startle gating deficits occur across prepulse intensities in schizophrenic patients

1992 • 332 citations

Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs

1995 • 231 citations

Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice

1997 • 216 citations

Antagonism of phencyclidine-induced deficits in prepulse inhibition by the putative atypical antipsychotic olanzapine

1995 • 194 citations

Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle

1991 • 189 citations

Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia

1993 • 189 citations

Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats

1994 • 179 citations

Seroquel restores sensorimotor gating in phencyclidine-treated rats.

1996 • 156 citations

Sensorimotor gating and habituation evoked by electro-cutaneous stimulation in schizophrenia

1994 • 149 citations

Blockade of phencyclidine-induced hyperlocomotion by clozapine and MDL 100,907 in rats reflects antagonism of 5-HT2A receptors

1995 • 121 citations

DOI disruption of prepulse inhibition of startle in the rat is mediated by 5-HT2A and not by 5-HT2C receptors

1995 • 115 citations

The role of serotonin in schizophrenia

1995 • 105 citations

The Phencyclidine-Glutamate Model of Schizophrenia

1995 • 102 citations

The effects of haloperidol and clozapine on the disruption of sensorimotor gating induced by the noncompetitive glutamate antagonist MK-801

1993 • 99 citations

Phencyclidine-induced deficits in prepulse inhibition of startle are blocked by prazosin, an alpha-1 noradrenergic antagonist.

1997 • 95 citations

Discrepant Findings of Clozapine Effects on Prepulse Inhibition of Startle: Is It the Route or the Rat?

1998 • 88 citations

Differential effects of apomorphine on prepulse inhibition of acoustic startle reflex in two rat strains

1990 • 85 citations

Differences between three rat strains in sensitivity to prepulse inhibition of an acoustic startle response: influence of apomorphine and phencyclidine pretreatment

1994 • 78 citations

MK-801-induced hyperlocomotion: Differential effects of M100907, SDZ PSD 958 and raclopride

1997 • 74 citations

M100907, A Selective 5-HT2A Receptor Antagonist and a Potential Antipsychotic Drug, Facilitates N-Methyl-D-Aspartate-Receptor Mediated Neurotransmission in the Rat Medial Prefrontal Cortical Neurons In Vitro

1998 • 74 citations

Glutamate pharmacology and the treatment of schizophrenia: current status and future directions

1995 • 73 citations

Disruption in prepulse inhibition after alpha-1 adrenoceptor stimulation in rats

1998 • 65 citations

Effects of Risperidone on Phencyclidine-Induced Behaviors: Comparison with Haloperidol and Ritanserin

1994 • 63 citations

(+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]- naphthyridine: A 5-HT2C/2B Receptor Antagonist with Low 5-HT2A Receptor Affinity

1995 • 58 citations

Reversal of a dizocilpine-induced disruption of prepulse inhibition of an acoustic startle response by the 5-HT2 receptor antagonist ketanserin

1995 • 56 citations

Modulation of phencyclidine-induced changes in locomotor activity and patterns in rats by serotonin

1998 • 32 citations