Demethylation and the Establishment of Allelic Exclusion

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Allelic inactivation regulates olfactory receptor gene expression

1994 • 1,056 citations

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1986 • 922 citations

Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line.

1992 • 729 citations

Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter.

1987 • 597 citations

The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses

1994 • 579 citations

Asynchronous Duplication of Chromosomes in Cultured Cells of Chinese Hamster

1960 • 530 citations

Ras C-terminal processing enzymes—New drug targets?

1991 • 461 citations

Efficient infection of monkey cells with DNA of simian virus 40.

1981 • 419 citations

Allele-specific replication timing of imprinted gene regions

1993 • 385 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

Role of DNA methylation in the regulation of transcription

1994 • 318 citations

Immunoglobulin Gene Transcription

1991 • 294 citations

Role of replication time in the control of tissue-specific gene expression.

1987 • 249 citations

The role of the κ enhancer and its binding factor NF-κB in the developmental regulation of κ gene transcription

1987 • 247 citations

Monoallelic Expression of the Interleukin-2 Locus

1998 • 232 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci

1991 • 223 citations

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.

1993 • 219 citations

Editing Disease-Associated Autoantibodies

1997 • 217 citations

A role for nuclear NF–κB in B–cell–specific demethylation of the Igκ locus

1996 • 216 citations

The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region.

1989 • 213 citations

κ chain monoallelic demethylation and the establishment of allelic exclusion

1998 • 203 citations

Allele specificity of DNA replication timing in the Angelman/Prader–Willi syndrome imprinted chromosomal region

1994 • 195 citations

Light chain replacement: a new model for antibody gene rearrangement.

1995 • 194 citations

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

1993 • 190 citations

DNA methylation: A molecular lock

1997 • 179 citations

B cell-specific demethylation: A novel role for the intronic κ chain enhancer sequence

1994 • 175 citations

Transcription Factors in Lymphocyte Development— T and B Cells Get Together

1999 • 169 citations

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.

1993 • 168 citations

CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication.

1992 • 168 citations

A Prematurely Expressed Igκ Transgene, but Not a VκJκ Gene Segment Targeted into the Igκ Locus, Can Rescue B Cell Development in λ5-Deficient Mice

1996 • 142 citations

TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events.

1993 • 132 citations

Immunoglobulin κ gene expression after stable integration

1989 • 120 citations

Changes in Locus-specific V(D)J Recombinase Activity Induced by Immunoglobulin Gene Products during B Cell Development

1997 • 116 citations

Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation.

1983 • 101 citations

The coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated.

1988 • 96 citations

Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells.

1994 • 91 citations

Both N- and C-Terminal Domains of RelB Are Required for Full Transactivation: Role of the N-Terminal Leucine Zipper-Like Motif

1993 • 87 citations

Immunoglobulin κ gene expression after stable integration

1989 • 81 citations

A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination.

1993 • 81 citations

Lipopolysaccharide-induced transcription of the kappa immunoglobulin locus occurs on both alleles and is independent of methylatlon status

1984 • 65 citations

The 3′ enhancer region determines the B/T specificity and pro-B/pre-B specificity of immunoglobulin Vκ-Jκ joining

1995 • 59 citations

Minireview

1998 • 58 citations

Methylation status of immunoglobulin x e segments correlates with their recombination potential

1993 • 49 citations

DNA methylation: regulation of gene expression and role in the immune system

1997 • 48 citations

V(D)J recombination moves

1997 • 47 citations

Allelic exclusion in B and T lymphopoiesis

1999 • 41 citations

Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif.

1993 • 36 citations

Developmental regulation of immune system gene rearrangement

1999 • 36 citations

Complementation between two cell lines lacking kappa enhancer activity: implications for the developmental control of immunoglobulin transcription.

1988 • 35 citations

The intronic immunoglobulin ϰ gene enhancer acts independently on rearrangement and on transcription

1993 • 35 citations

A new view of V(D)J recombination

1996 • 25 citations

The Mutant Plasmacytoma Cell Line S107 Allows the Identification of Distinct Pathways Leading to NF-κB Activation

1998 • 25 citations