Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice.

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Handbook of Mucosal Immunology

1994 • 711 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

1997 • 499 citations

Functions of CD40 on B cells, dendritic cells and other cells

1997 • 490 citations

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

1995 • 481 citations

Activation interferes with the APO-1 pathway in mature human T cells

1993 • 466 citations

Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.

1993 • 457 citations

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.

1994 • 431 citations

Co-stimulation in T cell responses

1997 • 430 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40

1996 • 421 citations

Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen.

1991 • 334 citations

Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation.

1982 • 320 citations

Dendritic Cells Enhance Growth and Differentiation of CD40-activated B Lymphocytes

1997 • 301 citations

CD28 costimulation promotes the production of Th2 cytokines.

1997 • 299 citations

The changing preference of T and B cells for partners as T‐dependent antibody responses develop

1997 • 292 citations

CD28 costimulation prevents cell death during primary T cell activation.

1996 • 270 citations

CD28 is required for germinal center formation.

1996 • 251 citations

Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation.

1997 • 247 citations

A lavage technique allowing repeated measurement of IgA antibody in mouse intestinal secretions

1984 • 229 citations

Impaired mucosal immune responses in interleukin 4-targeted mice.

1995 • 227 citations

Isolation of Mouse Small Intestinal Intraepithelial Lymphocytes, Peyer's Patch, and Lamina Propria Cells

1996 • 206 citations

Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro.

1991 • 192 citations

A genetically engineered non-toxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit

1997 • 180 citations

Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes.

1996 • 173 citations

Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse.

1994 • 167 citations

Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction.

1994 • 154 citations

Induction of B cell costimulatory function by recombinant murine CD40 ligand

1994 • 148 citations

The preference for switching to IgA expression by Peyer's patch germinal center B cells is likely due to the intrinsic influence of their microenvironment.

1991 • 141 citations

B cell function in mice transgenic for mCTLA4-H gamma 1: lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cells.

1994 • 136 citations

Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo.

1994 • 132 citations

Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells.

1995 • 129 citations

IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.

1994 • 126 citations

Cholera toxin adjuvant greatly promotes antigen priming of T cells

1993 • 121 citations

To ‘B’ or not to ‘B’ a germinal center?

1997 • 114 citations

Transepithelial transport and mucosal defence I: the role of M cells

1992 • 109 citations

CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L.

1996 • 101 citations

Essentials of Mucosal Immunology

1996 • 94 citations

B7/CD28-dependent and -independent induction of CD40 ligand expression.

1995 • 91 citations

Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation.

1995 • 79 citations

CD40 ligation in B cell activation, isotype switching and memory development

1994 • 78 citations

The function of costimulatory molecules and the development of IL-4-producing T cells

1997 • 73 citations

CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response.

1997 • 70 citations

Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response.

1997 • 70 citations

Reaction of germinal centers in the T-cell-independent response to the bacterial polysaccharide alpha(1-->6)dextran.

1994 • 64 citations

Enhancement of mucosal antibody responses to Salmonella typhimurium and the microbial hapten phosphorylcholine in mice with X-linked immunodeficiency by B-cell precursors from the peritoneal cavity

1992 • 56 citations

B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression.

1997 • 55 citations

A Major Peritoneal Reservoir of Precursors for Intestinal IgA Plasma Cells

1989 • 53 citations

Normal B cells fail to secrete interleukin-12

1997 • 52 citations

Host defense against cholera toxin is strongly CD4+ T cell dependent

1991 • 52 citations

Germinal center formation in mice lacking αβ T cells

1996 • 48 citations

Role of environmental antigens in the ontogeny of the secretory immune response.

1980 • 48 citations

Cholera toxin promotes B cell isotype switching by two different mechanisms. cAMP induction augments germ-line Ig H-chain RNA transcripts whereas membrane ganglioside GM1-receptor binding enhances later events in differentiation.

1993 • 48 citations

IL-10 selectively regulates murine Ig isotype switching

1996 • 47 citations

Distribution and Characteristics of Mucosal Immunoglobulin-Producing Cells

1994 • 46 citations

Peyer's Patches as Inductive Sites for IgA Commitment

1994 • 46 citations

Regulation of IgA B Cell Development

1994 • 33 citations

In vitro synthesized immunoglobulin A from nu/+ and reconstituted nu/nu mice against a dominant surface antigen ofGiardia lamblia

1993 • 32 citations

Peritoneal cavity CD5 (Bla) B cells: Cytokine induced IgA secretion and homing to intestinal lamina propria in SCID mice

1995 • 26 citations

Activated B cells express CD28/B7-independent costimulatory activity.

1996 • 26 citations

The Role of B-1 Cells in Mucosal Immune Responses

1994 • 17 citations

Measurement of Immunoglobulin Synthesis Using the ELISPOT Assay

1996 • 16 citations

Differential activation requirements of isotype-switched B cells

1996 • 15 citations

A Molecular Approach to the Construction of an Effective Mucosal Vaccine Adjuvant

1996 • 10 citations

Reciprocal regulation of mucosal surface IgA+ B cells by Ig receptor cross-linking and CD40 ligand.

1996 • 8 citations