Modulation of Cell-adhesive Activity of Fibronectin by the Alternatively Spliced EDA Segment

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Cell Biology of Extracellular Matrix

1988 • 1,498 citations

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

1993 • 1,279 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

Three different fibronectin mRNAs arise by alternative splicing within the coding region

1983 • 713 citations

Embryonic mesodermal defects in α5 integrin-deficient mice

1993 • 694 citations

Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.

1985 • 659 citations

2.0 Å Crystal Structure of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop and Synergy Region

1996 • 621 citations

The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function.

1994 • 617 citations

Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat.

1989 • 489 citations

Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis.

1994 • 444 citations

Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments.

1986 • 429 citations

Partial primary structure of bovine plasma fibronectin: Three types of internal homology

1983 • 399 citations

A tumor-associated fibronectin isoform generated by alternative splicing of messenger RNA precursors.

1989 • 339 citations

Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon.

1987 • 334 citations

Fibroblast cellular and plasma fibronectins are similar but not identical

1979 • 316 citations

Multiple sites of alternative splicing of the rat fibronectin gene transcript.

1987 • 299 citations

Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin.

1994 • 294 citations

[27] Arginine-glycine-aspartic acid adhesion receptors

1987 • 263 citations

Differential expression of the ed sequence-containing form of cellular fibronectin in embryonic and adult human tissues

1987 • 251 citations

Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains dfffering in the number of internal repeats

1984 • 221 citations

Alternative splicing of fibronectin is temporally and spatially regulated in the chicken embryo

1989 • 219 citations

Tumor Formation Dependent on Proteoglycan Biosynthesis

1988 • 217 citations

Conformational states of fibronectin. Effects of pH, ionic strength, and collagen binding.

1982 • 213 citations

Alternative Splicing of Fibronectin—Many Different Proteins but Few Different Functions

1995 • 206 citations

Monoclonal antibodies in the analysis of fibronectin isoforms generated by alternative splicing of mRNA precursors in normal and transformed human cells.

1987 • 204 citations

Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins.

1994 • 198 citations

Fibronectin in extended and compact conformations. Electron microscopy and sedimentation analysis.

1983 • 198 citations

[42] Selection and coamplification of heterologous genes in mammalian cells

1990 • 184 citations

Characterization of a major fibroblast cell surface glycoprotein

1977 • 182 citations

Characterization of regions of fibronectin besides the arginine-glycine-aspartic acid sequence required for adhesive function of the cell-binding domain using site-directed mutagenesis

1991 • 180 citations

Monoclonal antibody and synthetic peptide inhibitors of human tumor cell migration.

1990 • 176 citations

Domain structure of the carboxyl-terminal half of human plasma fibronectin.

1983 • 176 citations

The interaction of fibronectin fragments with fibroblastic cells.

1985 • 168 citations

Requirement for the Synergy Site for Cell Adhesion to Fibronectin Depends on the Activation State of Integrin α5β1

1995 • 164 citations

Altered rate of fibronectin matrix assembly by deletion of the first type III repeats.

1996 • 154 citations

The alternative splicing of fibronectin pre-mRNA is altered during aging and in response to growth factors

1991 • 151 citations

Fibronectin self-association is mediated by complementary sites within the amino-terminal one-third of the molecule.

1994 • 143 citations

Requirement for VLA-4 and VLA-5 integrins in lymphoma cells binding to and migration beneath stromal cells in culture.

1992 • 137 citations

Fibronectin and Other Cell Interactive Glycoproteins

1991 • 135 citations

A novel role for the integrin-binding III-10 module in fibronectin matrix assembly.

1996 • 133 citations

Cryptic Self-association Sites in Type III Modules of Fibronectin

1997 • 113 citations

Crystal structure of tandem type III fiibronectin domains from drosophila neuroglian at 2.0 å

1994 • 104 citations

Integrin alpha 8 beta 1 promotes attachment, cell spreading, and neurite outgrowth on fibronectin.

1995 • 104 citations

Differences in domain structure between human fibronectins isolated from plasma and from culture supernatants of normal and transformed fibroblasts. Studies with domain-specific antibodies.

1985 • 96 citations

Deregulation of Alternative Splicing of Fibronectin Pre-mRNA in Malignant Human Liver Tumors

1989 • 89 citations

Retroviral expression of alternatively spliced forms of rat fibronectin.

1990 • 84 citations

Multiple fibronectin subunits and their post-translational modifications.

1984 • 84 citations

Assembly of fibronectin into extracellular matrix

1993 • 83 citations

Selective secretion of alternatively spliced fibronectin variants.

1989 • 82 citations

Patterns of alternative splicing of fibronectin pre-mRNA in human adult and fetal tissues

1989 • 80 citations

Human liver fibronectin complementary DNAs: identification of two different messenger RNAs possibly encoding the .alpha. and .beta. subunits of plasma fibronectin

1986 • 74 citations

Carbohydrate structure of hamster plasma fibronectin. Evidence for chemical diversity between cellular and plasma fibronectins.

1982 • 70 citations

Primary Structure of Fibronectin

1989 • 60 citations

Coordinate oncodevelopmental modulation of alternative splicing of fibronectin pre-messenger RNA at ED-A, ED-B, and CS1 regions in human liver tumors.

1993 • 58 citations

Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin.

1996 • 54 citations

Adhesion Activity in Fibronectin's Alternatively Spliced Domain EDa (EIIIA): Complementarity to Plasma Fibronectin Functions

1995 • 41 citations

Human plasma fibronectin structure probed by steady-state fluorescence polarization: evidence for a rigid oblate structure

1990 • 38 citations

Adhesion Activity in Fibronectin's Alternatively Spliced Domain EDa (EIIIA) and Its Neighboring Type III Repeats: Oncogene-Dependent Regulation

1994 • 37 citations

Distinct Structural Requirements for Interaction of the Integrins α5β1, αvβ5, and αvβ6 with the Central Cell Binding Domain in Fibronectin

1996 • 31 citations

Adherence of synovial cells on EDA‐containing fibronectin

1996 • 19 citations

Probing molecular polymorphism of fibronectins with antibodies directed to the alternatively spliced peptide segments

1989 • 18 citations

Recombinant carboxyl-terminal fibrin-binding domain of human fibronectin expressed in mouse L cells.

1990 • 13 citations

Targeting of the Immunoglobulin-Binding Domain of Protein A to the Extracellular Matrix Using a Minifibronectin Expression Vector1

1994 • 5 citations