Predictive value of topoisomerase IIα and other prognostic factors for epirubicin chemotherapy in advanced breast cancer

Histological Grading and Prognosis in Breast Cancer

1957 • 2,897 citations

c-erbB-2 Expression and Response to Adjuvant Therapy in Women with Node-Positive Early Breast Cancer

1994 • 981 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

DNA Topoisomerases: Essential Enzymes and Lethal Targets

1994 • 722 citations

Assessment of response to therapy in advanced breast cancer

1977 • 705 citations

Structure and Function of the p53 Tumor Suppressor Gene: Clues for Rational Cancer Therapeutic Strategies

1996 • 666 citations

Assessment of response to therapy in advanced breast cancer.A project of the programme on clinical oncology of the International Union against Cancer, Geneva, Switzerland

1977 • 633 citations

Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

1995 • 501 citations

Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells.

1994 • 439 citations

Structure and function of type II DNA topoisomerases

1994 • 400 citations

Association of C‐erbB‐2 protein over‐expression with high rate of cell proliferation, increased risk of visceral metastasis and poor long‐term survival in breast cancer

1991 • 354 citations

Association of Overexpression of Tumor Suppressor Protien p53 With Rapid Cell Proliferation and Poor Prognosis in Node-Negative Breast Cancer Patients

1992 • 349 citations

Loss of estrogen receptor in recurrent breast cancer is associated with poor response to endocrine therapy.

1996 • 347 citations

The c-erbB-2 proto-oncogene as a prognostic and predictive marker in breast cancer: A paradigm for the development of other macromolecular markers-A review

1995 • 260 citations

Comparison of fresh and paraffin‐embedded tissue as starting material for DNA flow cytometry and evaluation of intratumor heterogeneity

1988 • 220 citations

Possible role of tissue‐bound calcium ions in citrate‐mediated high‐temperature antigen retrieval

1994 • 189 citations

Antitopoisomerase drug action and resistance

1996 • 176 citations

Cancer progression and p53

1995 • 174 citations

Nuclear topoisomerase II levels correlate with the sensitivity of mammalian cells to intercalating agents and epipodophyllotoxins.

1988 • 166 citations

Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines.

1991 • 165 citations

Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas

1996 • 149 citations

Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA.

1993 • 138 citations

Expression of topoisomerase IIalpha is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer.

1996 • 120 citations

Topoisomerase II alpha co-amplification with erbB2 in human primary breast cancer and breast cancer cell lines: relationship to m-AMSA and mitoxantrone sensitivity.

1993 • 115 citations

Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia

1994 • 113 citations

Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin.

1996 • 113 citations

Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, and cell proliferation characteristics in non-small cell lung cancer cell lines

1996 • 104 citations

Apurinic Sites Are Position-specific Topoisomerase II Poisons

1997 • 99 citations

Drug-induced DNA damage and tumor chemosensitivity.

1990 • 96 citations

Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with adriamycin by using a p53-independent pathway.

1996 • 78 citations

Co-amplification of erbB2, topoisomerase II α and retinoic acid receptor α genes in breast cancer and allelic loss at topoisomerase I on chromosome 20

1993 • 73 citations

Factors predicting for response, time to treatment failure, and survival in women with metastatic breast cancer treated with DAVTH: a prospective Eastern Cooperative Oncology Group study.

1991 • 72 citations

Improved prognostic impact of S‐phase values from paraffin‐embedded breast and prostate carcinomas after correcting for nuclear slicing

1991 • 69 citations

Differential expression of the topoisomerase IIα and β genes in human breast cancers

1996 • 68 citations

Response to mitoxantrone in advanced breast cancer: correlation with expression of c-erbB-2 protein and glutathione S-transferases

1992 • 66 citations

Proliferation-associated nuclear antigen Ki-S1 is identical with topoisomerase II alpha. Delineation of a carboxy-terminal epitope with peptide antibodies.

1995 • 64 citations

Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines

1995 • 61 citations

Spontaneous DNA Damage Stimulates Topoisomerase II-mediated DNA Cleavage

1997 • 59 citations

Differential expression of DNA topoisomerase II α and -β in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4

1996 • 58 citations

Interphase cytogenetic analysis of erbB2 and topollα co‐amplification in invasive breast cancer and polysomy of chromosome 17 in ductal carcinoma in situ

1995 • 56 citations

Her2/neu overexpression is associated with treatment failure in women with high-risk stage II and stage IIIA breast cancer (>10 involved lymph nodes) treated with high-dose chemotherapy and autologous hematopoietic progenitor cell support following standard-dose adjuvant chemotherapy.

1996 • 47 citations

DNA Topoisomerases: Essential Enzymes and Lethal Targets

1994 • 46 citations

Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?

1995 • 44 citations

Histological grade, elastosis, DNA ploidy and the response to chemotherapy of breast cancer

1987 • 44 citations

c-erbB-2 Expression and Response to Adjuvant Therapy in Women with Node-Positive Early Breast Cancer

1994 • 41 citations

Transfection of human topoisomerase IIα into etoposide-resistant cells: transient increase in sensitivity followed by down-regulation of the endogenous gene

1996 • 36 citations

Immunohistochemical study of topoisomerase II-alpha expression in primary ductal carcinoma of the breast.

1995 • 35 citations

p21WAF1/CIP1 response to genotoxic agents in wild-type TP53 expressing breast primary tumours

1997 • 35 citations

Immunocytochemical detection of DNA topoisomerase type II in primary breast carcinomas: Correlation with clinico-pathological features

1993 • 30 citations

Ectopic expression of inactive forms of yeast DNA topoisomerase II confers resistance to the anti-tumour drug, etoposide

1996 • 27 citations

Silver enhancement of polymerised diaminobenzidine: increased sensitivity for immunoperoxidase staining.

1991 • 21 citations

Effect of transfection of a Drosophila topoisomerase II gene into a human brain tumour cell line intrinsically resistant to etoposide

1996 • 18 citations

Alteration of p53 damage response by tamoxifen treatment.

1996 • 17 citations

Response to epirubicin in patients with superficial bladder cancer and expression of the topoisomerase II α and β genes

1996 • 11 citations

Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia

1994 • 7 citations

Prognostic and Predictive Factors

2012 • 5 citations