Alteration of p53 damage response by tamoxifen treatment.

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 • 607 citations

Risk of endometrial cancer after tamoxifen treatment of breast cancer

1994 • 574 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells.

1995 • 422 citations

Development of antiestrogens and their use in breast cancer: eighth Cain memorial award lecture.

1990 • 419 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth.

1982 • 393 citations

Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity.

1994 • 333 citations

Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents.

1996 • 298 citations

Effects of tamoxifen on human breast cancer cell cycle kinetics: accumulation of cells in early G1 phase.

1983 • 275 citations

Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7.

1995 • 272 citations

Antiestrogen inhibition of cell cycle progression in breast cancer cells in associated with inhibition of cyclin-dependent kinase activity and decreased retinoblastoma protein phosphorylation.

1995 • 179 citations

To pop or not to pop: p53 as a critical modulator of tumour responsiveness to therapy in vivo?

1995 • 168 citations

Lack of genotoxicity of tamoxifen in human endometrium.

1996 • 129 citations

Effects of antioestrogens on the proliferation of MCF-7 human breast cancer cells

1989 • 110 citations

Hormonal Regulation of the p53 Tumor Suppressor Protein in T47D Human Breast Carcinoma Cell Line

1995 • 80 citations

A functional screen for germ line p53 mutations based on transcriptional activation.

1992 • 66 citations

Protein synthesis—dependent cytoplasmic translocation of p53 protein after serum stimulation of growth‐arrested MCF‐7 cells

1993 • 39 citations

p53 as a growth suppressor gene in HBV-related hepatocellular carcinoma cells.

1993 • 32 citations