Cancer progression and p53

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

The multistep nature of cancer

1993 • 1,872 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Apoptosis and disease

1993 • 684 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair

1994 • 657 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.

1993 • 471 citations

The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis

1994 • 428 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.

1995 • 198 citations

p53 and human cancers

1994 • 192 citations

Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

1994 • 177 citations

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.

1994 • 168 citations

Relationship of p53 to the control of apoptotic cell death.

1994 • 163 citations

Quantification of p53 protein in tumor cell lines, breast tissue extracts and serum with time-resolved immunofluorometry.

1993 • 58 citations

The oncogene factsbook

1995 • 22 citations

The oncogene facts book

1996 • 6 citations