Characterization of signaling pathways to na+/H+ exchanger activation with epidermal growth factor in hepatocytes

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.

1991 • 1,282 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Liver regeneration: molecular mechanisms of growth control

1990 • 922 citations

Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers.

1986 • 831 citations

Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes

1986 • 790 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Molecular cloning, primary structure, and expression of the human growth factor-activatable antiporter

1989 • 774 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation

1989 • 749 citations

Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts

1983 • 721 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

Effects of Growth Factors on Intracellular pH Regulation

1986 • 498 citations

Growth Factors Induce Phosphorylation of the Na ⁺ /H ⁺ Antiporter, a Glycoprotein of 110 kD

1990 • 452 citations

Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH

1984 • 447 citations

[30] Use and specificity of genistein as inhibitor of protein-tyrosine kinases

1991 • 421 citations

Inositol trisphosphate and diacylglycerol as intracellular second messengers in liver

1985 • 419 citations

Growth factors immediately raise cytoplasmic free Ca2+ in human fibroblasts.

1984 • 394 citations

Increased sodium ion influx is necessary to initiate rat hepatocyte proliferation

1979 • 376 citations

Characterization of Cytosolic Calcium Oscillations Induced by Phenylephrine and Vasopressin in Single Fura-2-loaded Hepatocytes

1989 • 369 citations

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

1990 • 314 citations

The epidermal growth factor-induced calcium signal in A431 cells.

1986 • 297 citations

Na+/H+ antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinization.

1982 • 282 citations

Spatial and temporal aspects of cell signalling

1988 • 278 citations

Biological effects of epidermal growth factor, with emphasis on the gastrointestinal tract and liver: An update

1989 • 272 citations

Activation of Na+/H+ exchange by epidermal growth factor elevates intracellular pH in A431 cells.

1983 • 230 citations

Epidermal growth factor induces electrically silent Na+ influx in human fibroblasts.

1982 • 218 citations

Persistent intracellular calcium pool depletion by thapsigargin and its influence on cell growth.

1991 • 206 citations

Ca2+ Oscillations Induced by Hormonal Stimulation of Individual Fura-2-loaded Hepatocytes

1989 • 195 citations

Alpha-thrombin, epidermal growth factor, and okadaic acid activate the Na+/H+ exchanger, NHE-1, by phosphorylating a set of common sites.

1991 • 189 citations

Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger.

1991 • 178 citations

[27] Properties and use of H-series compounds as protein kinase inhibitors

1991 • 131 citations

Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes.

1991 • 121 citations

Extracellular Na+ and initiation of DNA synthesis: role of intracellular pH and K+.

1984 • 117 citations

Bicarbonate-dependent and -independent intracellular pH regulatory mechanisms in rat hepatocytes. Evidence for Na+-HCO3- cotransport.

1989 • 108 citations

Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes.

1986 • 101 citations

Role of phosphoinositides in the regulation of liver function

1988 • 101 citations

Epidermal growth factor mimics insulin effects in rat hepatocytes

1986 • 96 citations

Mitogen‐independent activation of Na⁺/H⁺ exchange in human epidermoid carcinoma A431 cells: Regulation by medium osmolarity

1985 • 92 citations

Agonist-evoked alkaline shift in the cytosolic pH set point for activation of Na+/H+ antiport in human platelets. The role of cytosolic Ca2+ and protein kinase C.

1990 • 68 citations

Both protein kinase C and calcium mediate activation of the Na⁺/H⁺ antiporter in Chinese hamster embryo fibroblasts

1987 • 57 citations

Cl(-)-HCO3- exchanger in isolated rat hepatocytes: role in regulation of intracellular pH

1991 • 50 citations

Intracellular calcium as a second messenger for human hepatocyte growth factor in hepatocytes

1992 • 44 citations

Effects of osmotic stresses on isolated rat hepatocytes. II. Modulation of intracellular pH

1990 • 44 citations

Na+/H+ exchange involvement in colony-stimulating factor-1-stimulated macrophage proliferation. Evidence for a requirement during late G1 of the cell cycle but not for early growth factor responses.

1990 • 43 citations

Epidermal growth factor and cyclic AMP stimulate Na⁺/H⁺ exchange in isolated rat hepatocytes

1990 • 42 citations

Selective suppression of growth factor-induced cell cycle gene expression by Na+/H+ antiport inhibitors.

1992 • 36 citations

Epidermal growth factor induces dose-dependent calcium oscillations in single fura-2–loaded Hepatocytes

1992 • 36 citations

A common mechanism for activation of the Na ⁺ /H ⁺ exchanger by different types of stimuli

1989 • 29 citations

Intracellular calcium-mediated activation of hepatic Na+/H+ exchange by arginine vasopressin and phenylephrine

1992 • 22 citations

Epidermal Growth Factor Elevates Intracellular pH in Chicken Granulosa Cells by Activating Protein Kinase C*

1991 • 16 citations

Stimulation of porcine thyroid cell alkalinization and growth by EGF, phorbol ester, and diacylglycerol

1990 • 9 citations