Epidermal growth factor mimics insulin effects in rat hepatocytes

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2'0 acetylation by acetic anhydride in aqueous solution.

1975 • 932 citations

Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.

1981 • 735 citations

Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system

1982 • 680 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices

1985 • 641 citations

RADIOIMMUNOASSAY FOR THE MEASUREMENT OF ADENOSINE 3′,5′-CYCLIC PHOSPHATE

1969 • 600 citations

Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor.

1979 • 530 citations

Insulin Receptors in the Liver: Specific Binding of [ ¹²⁵ I]Insulin to the Plasma Membrane and Its Relation to Insulin Bioactivity

1971 • 494 citations

Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands

1985 • 450 citations

Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells

1981 • 426 citations

A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes

1976 • 417 citations

Phosphoinositides in mitogenesis: Neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation

1985 • 332 citations

The Nature and Regulation of the Insulin Receptor: Structure and Function

1985 • 318 citations

Epidermal growth factor-dependent phosphorylation of lipocortin

1986 • 303 citations

The epidermal growth factor-induced calcium signal in A431 cells.

1986 • 297 citations

Stimulation of forskolin of intact S49 lymphoma cells involves the nucleotide regulatory protein of adenylate cyclase.

1982 • 240 citations

Epidermal growth factor

1974 • 236 citations

Receptor-mediated phosphorylation of the hepatic insulin receptor: Evidence that the M _r 95,000 receptor subunit is its own kinase

1983 • 213 citations

Stimulation of inositol trisphosphate formation in hepatocytes by vasopressin, adrenaline and angiotensin II and its relationship to changes in cytosolic free Ca2+

1985 • 212 citations

Stimulation of a low Km phosphodiesterase from liver by insulin and glucagon.

1978 • 208 citations

THE ROLE OF CYCLIC AMP IN THE INTERACTION OF GLUCAGON AND INSULIN IN THE CONTROL OF LIVER METABOLISM*

1971 • 205 citations

Hormonal control of cyclic 3':5'-AMP levels and gluconeogenesis in isolated hepatocytes from fed rats

1975 • 202 citations

Hormonal and ionic control of the glycogenolytic cascade in rat liver

1977 • 198 citations

Purification and characterization of epidermal growth factor receptor/protein kinase from normal mouse liver.

1982 • 183 citations

Regulation of adenylate cyclase of human platelet membranes by forskolin.

1982 • 178 citations

Mechanism of Control of Hepatic Glycogenesis by Insulin

1973 • 159 citations

Insulin and glucagon stimulation of amino acid transport in isolated rat hepatocytes. Synthesis of a high affinity component of transport.

1979 • 155 citations

Insulin and glucagon stimulation of (Na+-K+)-ATPase transport activity in isolated rat hepatocytes.

1981 • 150 citations

Age-related changes in the control of hepatic cyclic AMP levels by alpha 1- and beta 2-adrenergic receptors in male rats.

1983 • 150 citations

Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase.

1986 • 142 citations

A comparison of the insulin- and epidermal growth factor-stimulated protein kinases from human placenta.

1984 • 137 citations

Glycolysis in quiescent cultures of 3T3 cells. Stimulation by serum, epidermal growth factor, and insulin in intact cells and persistence of the stimulation after cell homogenization.

1978 • 128 citations

The relationships between receptor binding capacity for norepinephrine, angiotensin II, and vasopressin and release of inositol trisphosphate, Ca2+ mobilization, and phosphorylase activation in rat liver.

1985 • 109 citations

Studies on alpha-adrenergic activation of hepatic glucose output. Insulin inhibition of alpha-adrenergic and glucagon actions in normal and calcium-depleted hepatocytes.

1979 • 109 citations

Neomycin: a specific drug to study the inositol‐phospholipid signalling system?

1986 • 107 citations

Discriminative insulin antagonism of stimulatory effects of various cAMP analogs on adipocyte lipolysis and hepatocyte glycogenolysis.

1985 • 104 citations

Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes.

1986 • 101 citations

Alteration of epidermal growth factor-dependent phosphorylation during rat liver regeneration.

1982 • 96 citations

Insulin regulation of hepatic glycogen synthase and phosphorylase

1978 • 95 citations

Both insulin and epidermal growth factor stimulate fatty acid synthesis and increase phosphorylation of acetyl‐CoA carboxylase and ATP‐citrate lyase in isolated hepatocytes

1985 • 76 citations

Basal and hormone-stimulated adenylate cyclase in liver plasma membranes: Measurement by radioimmunoassay of cyclic AMP

1973 • 75 citations

Insulin inhibition of α-adrenergic actions in liver

1981 • 73 citations

The Role of Calcium in Alpha-adrenergic Inactivation of Glycogen Synthase in Rat Hepatocytes and its Inhibition by Insulin

1980 • 68 citations

Tyrosine protein kinases.

1984 • 64 citations

[43] Assessment of effects of vasopressin, angtiotensin II, and glucagon on Ca2+fluxes and phosphorylase activity in liver

1985 • 56 citations

Substrate specificities of insulin and epidermal growth factor receptor kinases

1985 • 48 citations

Interactions between insulin and alpha 1-adrenergic agents in the regulation of glycogen metabolism in isolated hepatocytes.

1985 • 46 citations

Epidermal growth factor stimulates monovalent cation transport in isolated rat hepatocytes

1981 • 45 citations

An assessment of the ability of insulin-stimulated cyclic AMP phosphodiesterase to decrease hepatocyte intracellular cyclic AMP concentrations

1984 • 37 citations

Insulin counteraction of α-adrenergic effects on liver glycogen metabolism

1978 • 36 citations

Epidermal growth factor stimulates glycogen synthase activity in cultured cells.

1985 • 32 citations

Insulin activation of basal hepatic glycogen synthase

1981 • 29 citations

Insulin inactivation of rat hepatocyte cyclic AMP‐dependent protein kinase

1981 • 29 citations

EGF inhibits glucagon stimulation of amino acid transport in primary cultures of adult rat hepatocytes

1981 • 24 citations

Differential short-term effects of growth factors on fatty acid synthesis in isolated rat-liver cells

1985 • 15 citations

Characterization of the epidermal‐growth‐factor‐dependent phosphorylation system from normal mouse‐liver sinusoidal plasma membranes

1983 • 6 citations

Is extracellular calcium required for insulin action?

1980 • 4 citations