Interaction of T Lymphocytes with Cerebral Endothelial Cells in vitro

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

Identification of an inducible endothelial-leukocyte adhesion molecule.

1987 • 1,639 citations

Biology of interleukin 1

1988 • 1,547 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Cytokines and endothelial cell biology

1990 • 1,275 citations

Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

1987 • 1,210 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

1986 • 1,079 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

Leukocyte adhesion to endothelium in inflammation

1990 • 882 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo.

1987 • 718 citations

Adhesion molecules controlling lymphocyte migration

1989 • 654 citations

Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes.

1981 • 592 citations

Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.

1984 • 579 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE.

1990 • 500 citations

Electrical resistance of brain microvascular endothelium

1982 • 478 citations

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

1986 • 471 citations

Endothelial Interleukin-8: A Novel Inhibitor of Leukocyte-Endothelial Interactions

1989 • 459 citations

Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species.

1987 • 418 citations

Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins.

1989 • 411 citations

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy

1989 • 394 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis.

1990 • 350 citations

Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase

1984 • 344 citations

Homing Receptors and Vascular Addressins: Cell Adhesion Molecules that Direct Lymphocyte Traffic

1989 • 332 citations

Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different.

1989 • 321 citations

In Vivo Activated T Lymphocytes in the Peripheral Blood and Cerebrospinal Fluid of Patients with Multiple Sclerosis

1985 • 307 citations

Inhibition of endothelial cell proliferation by gamma-interferon.

1987 • 292 citations

Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium.

1989 • 288 citations

The fate of allogeneic and xenogeneic neuronal tissue transplanted into the third ventricle of rodents

1986 • 284 citations

Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells.

1982 • 261 citations

A permanent rat T cell line that mediates experimental allergic neuritis in the Lewis rat in vivo.

1984 • 257 citations

T cell recognition as the target for immune intervention in autoimmune disease

1989 • 218 citations

Ia-restricted encephalitogenic T lymphocytes mediating EAE lyse autoantigen-presenting astrocytes

1986 • 214 citations

The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis

1986 • 214 citations

Immunocytochemical localization of basic protein in major dense line regions of central and peripheral myelin

1982 • 214 citations

Interleukin 1 is an autocrine regulator of human endothelial cell growth.

1990 • 197 citations

Autoaggressive T lymphocyte lines recognizing the encephalitogenic region of myelin basic protein: in vitro selection from unprimed rat T lymphocyte populations.

1985 • 196 citations

Suppression of experimental autoimmune diseases and prolongation of allograft survival by treatment of animals with low doses of heparins.

1989 • 184 citations

Graft-vs.-host disease elicits expression of class I and class II histocompatibility antigens and the presence of scattered T lymphocytes in rat central nervous system.

1987 • 178 citations

Warner-Lambert/Parke-Davis Award lecture. Cellular and molecular mechanisms that direct leukocyte traffic.

1990 • 170 citations

Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor V beta-specific antibodies.

1990 • 164 citations

Topographical arrangement of membrane proteins in the intact myelin sheath. Lactoperoxidase incorproation of iodine into myelin surface proteins.

1975 • 164 citations

T cell receptor β chain usage in myelin basic protein‐specific rat T lymphocytes

1989 • 162 citations

Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein

1988 • 154 citations

Major histocompatibility complex-linked control of the murine immune response to myelin basic protein.

1985 • 154 citations

Rejection of fetal neocortical neural transplants by H-2 incompatible mice.

1987 • 149 citations

Expression of Ia-like antigens by human vascular endothelial cells is inducible in vitro: demonstration by monoclonal antibody binding and immunoprecipitation.

1982 • 147 citations

T lymphocyte lines producing or vaccinating against autoimmune encephalomyelitis (EAE). Functional activation induces peanut agglutinin receptors and accumulation in the brain and thymus of line cells

1983 • 145 citations

Interferon-gamma regulates an antigen specific for endothelial cells involved in lymphocyte traffic.

1986 • 145 citations

Immune function of the blood-brain barrier: incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro.

1990 • 140 citations

Stroke and Microcirculation

1988 • 134 citations

Interaction of T lymphocytes and macrophages with cultured vascular endothelial cells: Attachment, invasion, and subsequent degradation of the subendothelial extracellular matrix

1984 • 133 citations

Interleukin-6 gene expression in human endothelial cells: RNA start sites, multiple IL-6 proteins and inhibition of proliferation

1989 • 131 citations

Experimental allergic encephalomyelitis mediated by murine encephalitogenic T cell lines specific for myelin proteolipid apoprotein.

1987 • 115 citations

Tumor necrosis factor and immune interferon synergistically increase transcription of HLA class I heavy- and light-chain genes in vascular endothelium.

1990 • 109 citations

Protection from experimental allergic encephalomyelitis conferred by a monoclonal antibody directed against a shared idiotype on rat T cell receptors specific for myelin basic protein.

1988 • 104 citations

Tumor necrosis factor inhibits the proliferation of cultured capillary endothelial cells

1987 • 91 citations

Induction of experimental allergic encephalomyelitis in Lewis rats with purified synthetic peptides: delineation of antigenic determinants for encephalitogenicity, in vitro activation of cellular transfer, and proliferation of lymphocytes.

1985 • 88 citations

Immune response of Lewis rats to peptide C1 (residues 68-88) of guinea pig and rat myelin basic proteins.

1977 • 87 citations

Antibodies specific for VB8 receptor peptide suppress experimental autoimmune encephalomyelitis.

1990 • 82 citations

Autoimmune T cells: Immune recognition of normal and variant peptide epitopes and peptide-based therapy

1989 • 81 citations

Transfer of experimental allergic neuritis with P2-reactive T-cell lines

1985 • 79 citations

Acute Experimental Allergic Encephalomyelitis in SJL/J Mice Induced by a Synthetic Peptide of Myelin Proteolipid Protein

1990 • 78 citations

Autoimmune effector cells. II. Transfer of experimental allergic encephalomyelitis with a subset of T lymphocytes

1982 • 77 citations

A polypeptide factor produced by fibrosarcoma cells that induces endothelial tissue factor and enhances the procoagulant response to tumor necrosis factor/cachectin.

1990 • 72 citations

Ia antigens in the normal rat nervous system and in lesions of experimental allergic encephalomyelitis

1985 • 69 citations

Characterization of T cell lines and clones from SJL/J and (BALB/c x SJL/J)F1 mice specific for myelin basic protein.

1985 • 68 citations

T‐cell lymphoma in the CNS

1989 • 68 citations

Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens

1984 • 66 citations

Autoimmune encephalomyelitis (EAE) mediated or prevented by T lymphocyte lines directed against diverse antigenic determinants of myelin basic protein. Vaccination is determinant specific.

1983 • 64 citations

Differences in the repertoire of the Lewis rat T cell response to self and non-self myelin basic proteins.

1988 • 58 citations

Is the Brain "An Immunologically Privileged Site?"

1966 • 55 citations

The immune response of Lewis rats to peptide 68-88 of guinea pig myelin basic protein. II. B cell determinants.

1979 • 53 citations

T cell specificity for class II (I-A) and the encephalitogenic N-terminal epitope of the autoantigen myelin basic protein.

1987 • 52 citations

Immunologic study of the brain as a privileged site.

1977 • 48 citations

Inhibitory effect of human recombinant interleukin-1 α and β on growth of human vascular endothelial cells

1987 • 47 citations

Antigen presentation by brain microvessel smooth muscle and endothelium

1990 • 47 citations

Induction of Ia molecules on brain endothelium is related to susceptibility to experimental allergic encephalomyelitis

1989 • 46 citations

Antigen presentation in brain: brain endothelial cells are poor stimulators of T-cell proliferation.

1989 • 46 citations

Increased proportion of CD4+ CDw29+ CD45R− UCHL-1+ lymphocytes in the cerebrospinal fluid of both multiple sclerosis patients and healthy individuals

1989 • 42 citations

Lymphocyte-mediated activation of cultured endothelial cells (EC). CD4+ T cells inhibit EC class II MHC expression despite secreting IFN-gamma and increasing EC class I MHC and intercellular adhesion molecule-1 expression.

1990 • 39 citations

The Immunopathology of Acute Experimental Allergic Encephalomyelitis. IV. An Ultrastructural Immunocytochemical Study of Class II Major Histocompatibility Complex Molecule (Ia) Expression

1987 • 36 citations

The development and characterization of encephalitogenic cloned T cells specific for myelin proteolipid protein

1990 • 35 citations

Selective acceptance of MHC class I-deficient tumor grafts in the brain.

1988 • 35 citations

IMMUNOGENETIC ASPECTS OF TRANSPLANTATION IN THE RAT BRAIN

1985 • 33 citations

The Immune Response of Lewis Rats to Peptide 68–88 of Guinea Pig Myelin Basic Protein

1979 • 33 citations

Interleukin-1 inhibits the synthesis of von Willebrand factor in endothelial cells, which results in a decreased reactivity of their matrix toward platelets.

1987 • 28 citations

Differential expression of guinea pig class II major histocompatibility complex antigens on vascular endothelial cells in vitro and in experimental allergic encephalomyelitis

1989 • 25 citations

Chronic relapsing experimental allergic encephalomyelitis. Cytotoxicity effected by a class II restricted T cell line specific for an encephalitogenic epitope.

1989 • 23 citations

Encephalitogenic T cell clones with variant receptor specificity.

1988 • 22 citations

Passive transfer of experimental allergic encephalomyelitis induced by proteolipid apoprotein

1986 • 16 citations

Influence of the H-2u haplotype on immune function in F1 hybrid mice. I. Antigen presentation.

1985 • 14 citations

Hemorrhagic autoimmune encephalomyelitis induced by adoptive transfer of activated semiallogeneic spleen cells into irradiated rats.

1988 • 12 citations

Rat lymphokines control the migration of nonsensitized lymphocytes

1989 • 8 citations