Fingolimod for Multiple Sclerosis: Mechanism of Action, Clinical Outcomes, and Future Directions

IL-17 and Th17 Cells

2009 • 4,491 citations

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

2010 • 2,531 citations

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

2010 • 2,146 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

2007 • 1,595 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

2007 • 1,135 citations

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

2009 • 1,120 citations

Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis

2006 • 1,043 citations

Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

2010 • 739 citations

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

1999 • 723 citations

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

2005 • 681 citations

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

1998 • 586 citations

The immunosuppressant FTY720 down‐regulates sphingosine 1‐phosphate G protein‐coupled receptors

2004 • 532 citations

Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology

2007 • 524 citations

Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: a meta-analysis

1999 • 490 citations

Structural and functional characteristics of S1P receptors

2004 • 450 citations

Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis

2009 • 424 citations

Sphingosine 1-Phosphate Receptor Signaling

2009 • 399 citations

FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis

2008 • 326 citations

The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2

2003 • 300 citations

Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices

2010 • 257 citations

FTY720 modulates human oligodendrocyte progenitor process extension and survival

2007 • 251 citations

Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS study

2011 • 219 citations

Sphingosine‐1‐phosphate induces proliferation and morphological changes of neural progenitor cells

2004 • 195 citations

Sphingosine 1‐phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions

2010 • 193 citations

Oral fingolimod (FTY720) in multiple sclerosis

2009 • 193 citations

Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis

2010 • 191 citations

The Immunomodulator FTY720 Has a Direct Cytoprotective Effect in Oligodendrocyte Progenitors

2007 • 173 citations

Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results

2009 • 161 citations

Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells

2007 • 156 citations

The Immunology of Multiple Sclerosis

2008 • 155 citations

Physiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous Doses

2006 • 130 citations

Characterization of lysophosphatidic acid and sphingosine‐1‐phosphate‐mediated signal transduction in rat cortical oligodendrocytes

2003 • 121 citations

Microglial activation state and lysophospholipid acid receptor expression

2003 • 117 citations

Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors

2007 • 112 citations

The Sphingosine‐1‐Phosphate Receptor Agonist FTY720 Modulates Dendritic Cell Trafficking In Vivo

2005 • 111 citations

Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes

2003 • 94 citations

Cyclical and Dose-Dependent Responses of Adult Human Mature Oligodendrocytes to Fingolimod

2008 • 90 citations

Differential responses of human microglia and blood-derived myeloid cells to FTY720

2010 • 63 citations

Neurobiology of Receptor‐Mediated Lysophospholipid Signaling: From the First Lysophospholipid Receptor to Roles in Nervous System Function and Development

2000 • 47 citations

FTY720 treatment of kidney transplant patients: A differential effect on B cells, naïve T cells, memory T cells and NK cells

2006 • 43 citations

Pharmacokinetics and Cell Trafficking Dynamics of 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol Hydrochloride (FTY720) in Cynomolgus Monkeys after Single Oral and Intravenous Doses

2002 • 31 citations

Differential effects of single dose FTY720 on CD62L+ B-cells in stable renal allograft recipients

2006 • 7 citations