Microglial activation state and lysophospholipid acid receptor expression

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

Characterization of ameboid microglia isolated from developing mammalian brain

1986 • 1,287 citations

Functional plasticity of microglia: A review

1988 • 931 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Roles of G‐protein‐coupled receptor dimerization

2004 • 668 citations

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

1995 • 622 citations

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

2000 • 581 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

2002 • 462 citations

Bioactive Lysophospholipids and Their G Protein-Coupled Receptors

1999 • 412 citations

Lysophosphatidic Acid Receptors

2000 • 404 citations

Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors

2002 • 309 citations

EDG1 Is a Functional Sphingosine-1-phosphate Receptor That Is Linked via a Gi/o to Multiple Signaling Pathways, Including Phospholipase C Activation, Ca2+Mobilization, Ras-Mitogen-activated Protein Kinase Activation, and Adenylate Cyclase Inhibition

1998 • 279 citations

Flow Cytometric Analysis of Inflammatory Cells in Ischemic Rat Brain

2002 • 242 citations

Functional Comparisons of the Lysophosphatidic Acid Receptors, LP_A1/VZG-1/EDG-2, LP_A2/EDG-4, and LP_A3/EDG-7 in Neuronal Cell Lines Using a Retrovirus Expression System

2000 • 206 citations

cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.

1989 • 200 citations

Sphingosine 1-Phosphate-induced Cell Proliferation, Survival, and Related Signaling Events Mediated by G Protein-coupled Receptors Edg3 and Edg5

2000 • 196 citations

EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

2001 • 167 citations

The Inducible G Protein-coupled Receptor edg-1 Signals via the Gi/Mitogen-activated Protein Kinase Pathway

1996 • 167 citations

A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs)

1999 • 153 citations

Downregulation of G protein-coupled receptors

2000 • 146 citations

Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors

2002 • 130 citations

Characterization of lysophosphatidic acid and sphingosine‐1‐phosphate‐mediated signal transduction in rat cortical oligodendrocytes

2003 • 121 citations

Characterisation of microglia isolated from adult human and rat brain

1988 • 117 citations

Expression and Function of Lysophosphatidic Acid Receptors in Cultured Rodent Microglial Cells

2001 • 106 citations

Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes

2003 • 94 citations

Mouse resident microglia: Isolation and characterization of immunoregulatory properties with naïve CD4⁺and CD8⁺T‐cells

1998 • 78 citations

Obtention and characterization of primary astrocyte and microglial cultures from adult monkey brains

1997 • 74 citations

Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors

2001 • 61 citations

Mouse resident microglia: Isolation and characterization of immunoregulatory properties with na�ve CD4+ and CD8+ T-cells

1998 • 60 citations

A 20-Nucleotide (A + U)-rich Element of β2-Adrenergic Receptor (β2AR) mRNA Mediates Binding to β2AR-binding Protein and Is Obligate for Agonist-induced Destabilization of Receptor mRNA

1997 • 49 citations

Differential down-regulation of alpha-2 adrenergic receptor subtypes

1998 • 39 citations

Concurrent isolation and characterization of oligodendrocytes, microglia and astrocytes from adult human spinal cord

1993 • 38 citations

Microglia in the pineal gland of the neonatal rat: Characterization and effects on pinealocyte neurite length and serotonin content

1997 • 18 citations