FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

2004 • 2,910 citations

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis

2006 • 1,043 citations

Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis

2005 • 831 citations

The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms

2005 • 639 citations

Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines

2003 • 582 citations

Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology

2007 • 524 citations

Molecular Mechanisms of Lymphocyte Homing to Peripheral Lymph Nodes

1998 • 469 citations

Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone

2004 • 403 citations

Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells

1999 • 367 citations

FTY720 Immunosuppression Impairs Effector T Cell Peripheral Homing Without Affecting Induction, Expansion, and Memory

2000 • 364 citations

Amelioration of Experimental Autoimmune Encephalomyelitis in Lewis Rats by FTY720 Treatment

2003 • 281 citations

FTY720 modulates human oligodendrocyte progenitor process extension and survival

2007 • 251 citations

Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells

2007 • 156 citations

Immunological update on multiple sclerosis

2001 • 108 citations

Randomized Controlled Trial of FTY720 Versus MMF in De Novo Renal Transplantation

2006 • 107 citations

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis

2007 • 93 citations

Systemic T cell expansion during localized viral infection

1999 • 87 citations

Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses against Listeria monocytogenes

2007 • 15 citations