Phosphorylation of Threonine 210 and the Role of Serine 137 in the Regulation of Mammalian Polo-like Kinase

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Principles of CDK regulation

1995 • 3,267 citations

Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle

1995 • 918 citations

Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein

1996 • 900 citations

cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2

1991 • 870 citations

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

1996 • 685 citations

Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles

1988 • 546 citations

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

1996 • 506 citations

The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

1991 • 504 citations

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

1998 • 488 citations

Acid and base hydrolysis of phosphoproteins bound to Immobilon facilitates analysis of phosphoamino acids in gel-fractionated proteins

1989 • 469 citations

Polo-like kinases: a team that plays throughout mitosis

1998 • 424 citations

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

1995 • 376 citations

The Human Myt1 Kinase Preferentially Phosphorylates Cdc2 on Threonine 14 and Localizes to the Endoplasmic Reticulum and Golgi Complex

1997 • 354 citations

Polo-like kinases: positive regulators of cell division from start to finish

1998 • 346 citations

p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

1992 • 276 citations

Plk Is an M-Phase-Specific Protein Kinase and Interacts with a Kinesin-Like Protein, CHO1/MKLP-1

1995 • 266 citations

Activated Polo-Like Kinase Plx1 Is Required at Multiple Points during Mitosis in Xenopus laevis

1998 • 233 citations

The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts

1998 • 214 citations

A Spindle Checkpoint Arrest and a Cytokinesis Failure by the Dominant-negative Polo-box Domain of Plk1 in U-2 OS Cells

2002 • 213 citations

cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2.

1992 • 211 citations

On the Regulation and Function of Human Polo-like Kinase 1 (PLK1): Effects of Overexpression on Cell Cycle Progression

1997 • 199 citations

Functional studies on the role of the C-terminal domain of mammalian polo-like kinase

2002 • 194 citations

Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA

2002 • 183 citations

Plk Is a Functional Homolog of Saccharomyces cerevisiae Cdc5, and Elevated Plk Activity Induces Multiple Septation Structures

1997 • 179 citations

Polo-like Kinase Is a Cell Cycle-regulated Kinase Activated during Mitosis

1995 • 165 citations

Constitutive activation of Mek1 by mutation of serine phosphorylation sites.

1994 • 145 citations

Mitotic Effects of a Constitutively Active Mutant of the Xenopus Polo-Like Kinase Plx1

1999 • 135 citations

Purification and Cloning of a Protein Kinase That Phosphorylates and Activates the Polo-Like Kinase Plx1

1998 • 119 citations

Cell Cycle-regulated Phosphorylation of the XenopusPolo-like Kinase Plx1

2002 • 88 citations

Ste20‐like kinase (SLK), a regulatory kinase for polo‐like kinase (Plk) during the G2/M transition in somatic cells

2000 • 85 citations

The conserved mitotic kinase polo is regulated by phosphorylation and has preferred microtubule-associated substrates in Drosophila embryo extracts.

1996 • 84 citations

LOK Is a Novel Mouse STE20-like Protein Kinase That Is Expressed Predominantly in Lymphocytes

1997 • 83 citations

Analysis of Cell-Cycle Profiles in Transfected Cells Using a Membrane-Targeted GFP

1998 • 71 citations

Flow Cytometric Analysis of the Cell Cycle in Transfected Cells Without Cell Fixation

1999 • 22 citations