Characterization of a Trap Mutant of the AAA+ Chaperone ClpB

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

2000 • 14,118 citations

AAA⁺: A Class of Chaperone-Like ATPases Associated with the Assembly, Operation, and Disassembly of Protein Complexes

1999 • 1,793 citations

Hsp104, Hsp70, and Hsp40

1998 • 1,346 citations

AAA⁺ superfamily ATPases: common structure–diverse function

2001 • 953 citations

The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function

1998 • 746 citations

HSP100/Clp proteins: a common mechanism explains diverse functions

1996 • 653 citations

Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB

1999 • 587 citations

Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network

1999 • 578 citations

Mechanism of regulation of Hsp70 chaperones by DnaJ cochaperones

1999 • 554 citations

Hsp104 is required for tolerance to many forms of stress.

1992 • 546 citations

Aaa Proteins

2000 • 511 citations

Global unfolding of a substrate protein by the Hsp100 chaperone ClpA

1999 • 427 citations

Mutants of Arabidopsis thaliana defective in the acquisition of tolerance to high temperature stress

2000 • 422 citations

The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner

1990 • 407 citations

N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion.

1994 • 395 citations

ClpB Cooperates with DnaK, DnaJ, and GrpE in Suppressing Protein Aggregation

1999 • 346 citations

Genetic dissection of the roles of chaperones and proteases in protein folding and degradation in the Escherichia coli cytosol

2001 • 332 citations

The YTA10–12 Complex, an AAA Protease with Chaperone-like Activity in the Inner Membrane of Mitochondria

1996 • 312 citations

Heat-inactivated proteins are rescued by the DnaK⋅J-GrpE set and ClpB chaperones

1999 • 252 citations

Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP

2000 • 249 citations

Microtubule Disassembly by ATP-Dependent Oligomerization of the AAA Enzyme Katanin

1999 • 228 citations

Size-dependent Disaggregation of Stable Protein Aggregates by the DnaK Chaperone Machinery

2000 • 226 citations

Roles of the Escherichia coli Small Heat Shock Proteins IbpA and IbpB in Thermal Stress Management: Comparison with ClpA, ClpB, and HtpG In Vivo

1998 • 193 citations

Monomerization of RepA dimers by heat shock proteins activates binding to DNA replication origin.

1991 • 183 citations

MecA, an adaptor protein necessary for ClpC chaperone activity

2003 • 159 citations

Binding of transcriptional activators to sigma 54 in the presence of the transition state analog ADP–aluminum fluoride: insights into activator mechanochemical action

2001 • 124 citations

Defining a Pathway of Communication from the C-Terminal Peptide Binding Domain to the N-Terminal ATPase Domain in a AAA Protein

2002 • 123 citations

Structure and Activity of ClpB from Escherichia coli

2000 • 114 citations

Roles of the Two ATP Binding Sites of ClpB from Thermus thermophilus

2002 • 86 citations

The chaperone function of ClpB from Thermus thermophilus depends on allosteric interactions of its two ATP-binding sites

2001 • 84 citations

The N Terminus of ClpB from Thermus thermophilus Is Not Essential for the Chaperone Activity

2002 • 84 citations

Alternating translocation of protein substrates from both ends of ClpXP protease

2002 • 75 citations

Analysis of the AAA sensor-2 motif in the C-terminal ATPase domain of Hsp104 with a site-specific fluorescent probe of nucleotide binding

2002 • 68 citations

Concurrent Chaperone and Protease Activities of ClpAP and the Requirement for the N-terminal ClpA ATP Binding Site for Chaperone Activity

1999 • 54 citations

Cooperative Action of Escherichia coli ClpB Protein and DnaK Chaperone in the Activation of a Replication Initiation Protein

2002 • 50 citations

Role of Region C in Regulation of the Heat Shock Gene-Specific Sigma Factor of Escherichia coli , ς ³²

1999 • 49 citations

Inferences Concerning the ATPase Properties of DnaK and Other HSP70s Are Affected by the ADP Kinase Activity of Copurifying Nucleoside-diphosphate Kinase

1999 • 30 citations