Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Handbook of experimental pharmacology

1984 • 1,599 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Animal models of diabetes mellitus

2005 • 714 citations

After Insulin Binds

1987 • 687 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

The insulin receptor and the molecular mechanism of insulin action.

1988 • 426 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

Insulin Resistance is a Prominent Feature of Insulin-dependent Diabetes

1982 • 365 citations

Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats.

1984 • 237 citations

Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase

1991 • 198 citations

Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell.

1987 • 195 citations

Insulin binding to liver plasm membranes in the obese hyperglycemic (ob/ob) mouse. Demonstration of a decreased number of functionally normal receptors.

1975 • 152 citations

Divergent molecular mechanisms for insulin-resistant glucose transport in muscle and adipose cells in vivo.

1990 • 149 citations

Characterization of an endogenous substrate of the insulin receptor in cultured cells.

1987 • 136 citations

Purification of the catalytically active phosphorylated form of insulin receptor kinase by affinity chromatography with O-phosphotyrosyl-binding antibodies

1985 • 124 citations

The glucose transporter in 3T3-L1 adipocytes is phosphorylated in response to phorbol ester but not in response to insulin.

1986 • 121 citations

Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells.

1987 • 120 citations

Hepatic phosphotyrosine phosphatase activity and its alterations in diabetic rats.

1989 • 105 citations

Insulin receptor kinase activity in rat liver. Regulation by fasting and high carbohydrate feeding.

1985 • 96 citations

Molecular association between major histocompatibility complex class I antigens and insulin receptors in mouse liver membranes.

1985 • 87 citations

Insulin receptors with defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation.

1988 • 82 citations

Insulin-Receptor Autophosphorylation and Endogenous Substrate Phosphorylation in Human Adipocytes From Control, Obese, and NIDDM Subjects

1990 • 79 citations

Insulin Receptors and Insulin Resistance

1983 • 77 citations

Insulin-induced tyrosine-phosphorylation in intact rat adipocytes

1988 • 57 citations

7 The Insulin Receptor and Tyrosine Phosphorylation

1986 • 54 citations

Insulin action during fasting and refeeding in rat determined by euglycemic clamp

1985 • 53 citations

Effects of hypercortisolemia and diabetes on skeletal muscle insulin receptor function in vitro and in vivo

1989 • 47 citations

Autophosphorylation and kinase activity of insulin receptor in diabetic rats

1986 • 42 citations

Effect of Fasting on Insulin Binding to Hepatocytes and Liver Plasma Membranes from Rats*

1979 • 40 citations

Normal hepatic insulin receptor autophosphorylation in nonketotic diabetes mellitus

1985 • 36 citations

Immunological Detection of Phosphotyrosine-Containing Proteins in Rat Livers After Insulin Injection

1990 • 35 citations

Insulin binding and receptor tyrosine kinase activity in rat liver and skeletal muscle: Effect of starvation

1990 • 35 citations

Phospholipid activation of the insulin receptor kinase: regulation by phosphatidylinositol

1987 • 33 citations

Differential sensitivity of two functions of the insulin receptor to the associated proteolysis: kinase action and hormone binding.

1986 • 30 citations

Dexamethasone-Induced Changes in Phosphorylation of the Insulin and Epidermal Growth Factor Receptors and Their Substrates in Intact Rat Hepatocytes*

1988 • 30 citations

Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects

1990 • 29 citations

Brown Adipose Tissue in Lean and Obese Mice: Insulin-Receptor Binding and Tyrosine Kinase Activity

1986 • 28 citations

Insulin receptor tyrosine kinase activity is unaltered in ob/ob and db/db mouse skeletal muscle membranes

1987 • 26 citations

Intact Adipocyte Insulin-Receptor Phosphorylation and In Vitro Tyrosine Kinase Activity in Animal Models of Insulin Resistance

1988 • 25 citations

Intact adipocyte insulin-receptor phosphorylation and in vitro tyrosine kinase activity in animal models of insulin resistance

1988 • 10 citations

Diabetes-Associated Impairment of Hepatic Insulin Receptor Tyrosine Kinase Activity: A Study of Mechanisms*

1991 • 10 citations

Immunological detection of phosphotyrosine-containing proteins in rat livers after insulin injection

1990 • 8 citations