Lactate: mirror and motor of tumor malignancy

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

2000 • 1,769 citations

Oncogenic alterations of metabolism

1999 • 1,095 citations

HIF-1 and tumor progression: pathophysiology and therapeutics

2002 • 1,025 citations

Observations on the carbohydrate metabolism of tumours

1929 • 821 citations

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers.

2000 • 786 citations

Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis

2002 • 785 citations

Causes and consequences of tumour acidity and implications for treatment

2000 • 746 citations

Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells

2001 • 602 citations

Biologic Correlates of 18Fluorodeoxyglucose Uptake in Human Breast Cancer Measured by Positron Emission Tomography

2002 • 536 citations

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

2001 • 534 citations

Mitochondrial DNA in human malignancy

2001 • 438 citations

High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers.

2002 • 326 citations

Biologic Correlates of ¹⁸Fluorodeoxyglucose Uptake in Human Breast Cancer Measured by Positron Emission Tomography

2002 • 306 citations

An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: Role in tumor cell glycolysis and the Warburg effect

1999 • 281 citations

Glucose Regulation of Gene Transcription

2000 • 265 citations

Correlation of high lactate levels in head and neck tumors with incidence of metastasis.

1997 • 246 citations

Proteomic changes in renal cancer and co‐ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect

2003 • 242 citations

Correlation of high lactate levels in human cervical cancer with incidence of metastasis.

1995 • 216 citations

Lactate Stimulates Fibroblast Expression of Hyaluronan and CD44: The Warburg Effect Revisited

2002 • 204 citations

Mitochondrial proteome: Altered cytochrome c oxidase subunit levels in prostate cancer

2003 • 153 citations

Expression and secretion of neuroleukin/phosphohexose isomerase/maturation factor as autocrine motility factor by tumor cells.

1998 • 141 citations

HIF-1α mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma

2003 • 140 citations

Geldanamycin inhibits migration of glioma cells in vitro: A potential role for hypoxia‐inducible factor (HIF‐1α) in glioma cell invasion

2003 • 109 citations

Effect of Extracellular AMP on Cell Proliferation and Metabolism of Breast Cancer Cell Lines with High and Low Glycolytic Rates

1997 • 103 citations

Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7

2001 • 102 citations

Metabolic classification of human rectal adenocarcinomas: a novel guideline for clinical oncologists?

2003 • 97 citations

1H-MRS in vivo predicts the early treatment outcome of postoperative radiotherapy for malignant gliomas

2002 • 95 citations

Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging

1993 • 92 citations

Alterations in the activity and isozymic profile of human phosphofructokinase during malignant transformation in vivo and in vitro: transformation- and progression-linked discriminants of malignancy.

1985 • 89 citations

Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells

2002 • 87 citations

Hypoxia‐induced upregulation of eNOS gene expression is redox‐sensitive: A comparison between hypoxia and inhibitors of cell metabolism

2001 • 87 citations

Metabolic mapping with bioluminescence: basic and clinical relevance

2002 • 76 citations

Alterations in the glycolytic and glutaminolytic pathways after malignant transformation of rat liver oval cells

1999 • 69 citations

Radiation response non-invasively imaged by [18F]FDG-PET predicts local tumor control and survival in advanced oral squamous cell carcinoma

2002 • 56 citations

Lactate-sensitive response elements in genes involved in hyaluronan catabolism

2003 • 54 citations

Effect of glucose and deoxyglucose on the redistribution of calcium in Ehrlich ascites tumour and Zajdela hepatoma cells and its consequences for mitochondrial energetics

1999 • 50 citations

Positron emission tomography for the diagnosis of breast cancer

2002 • 50 citations

Autocrine motility factor secreted by tumor cells upregulates vascular endothelial growth factor receptor (Flt‐1) expression in endothelial cells

2002 • 43 citations

Regulation of Autocrine Motility Factor Receptor Expression in Tumor Cell Locomotion and Metastasis

1996 • 42 citations

Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis.

2001 • 39 citations

Role of oncogenic transcription factor c-Myc in cell cycle regulation, apoptosis and metabolism

1997 • 32 citations

Feasibility study of lactate imaging of head and neck tumors

1998 • 30 citations

Human Glucose Phosphate Isomerase: Exon Mapping and Gene Structure

1995 • 25 citations

Antihuman epidermal growth factor receptor 2 antibody herceptin inhibits autocrine motility factor (AMF) expression and potentiates antitumor effects of AMF inhibitors.

2002 • 19 citations

A new photometric method for oxygen consumption measurements in cell suspensions

1986 • 14 citations