Hypoxia reduces CD80 expression on monocytes but enhances their LPS-stimulated TNF-α secretion

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Germline Mutations in the Extracellular Domains of the 55 kDa TNF Receptor, TNFR1, Define a Family of Dominantly Inherited Autoinflammatory Syndromes

1999 • 1,363 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level.

1990 • 495 citations

Physiologic Mechanisms of Postischemic Tissue Injury

1995 • 427 citations

THE EFFECTS OF INJURY ON THE ADAPTIVE IMMUNE RESPONSE

1999 • 306 citations

Pharmacology of the Endothelium in Ischemia-Reperfusion and Circulatory Shock

1993 • 293 citations

Prevention of Activated Neutrophil Adhesion to Endothelium by Soluble Adhesion Protein GMP140

1990 • 257 citations

Apoptosis in sepsis: a new target for therapeutic exploration

2001 • 255 citations

CD80, CD86 and CD40 Provide Accessory Signals in a Multiple‐Step T‐Cell Activation Model

1996 • 243 citations

Reperfusion Injury

1992 • 236 citations

The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury.

1997 • 228 citations

Assays for tumour necrosis factor and related cytokines

1989 • 204 citations

A systematic study of host defense processes in badly injured patients.

1986 • 182 citations

Pathology of Intestinal Ischemia

1992 • 157 citations

TRAUMA-INDUCED SUPPRESSION OF ANTIGEN PRESENTATION AND EXPRESSION OF MAJOR HISTOCOMPATIBILITY CLASS II ANTIGEN COMPLEX IN LEUKOCYTES

1996 • 156 citations

Interactive effects of the tumor necrosis factor promoter and 3'-untranslated regions.

1991 • 153 citations

Anti-B7-1 blocks mononuclear cell adherence in vasa recta after ischemia

2001 • 137 citations

Hypoxia Induces a Human Macrophage Cell Line to Release Tumor Necrosis Factor-α and Its Soluble Receptors in Vitro

1993 • 121 citations

Pathophysiology of Mesenteric Ischemia

1992 • 114 citations

Differential effects of hemorrhage on kupffer cells: decreased antigen presentation despite increased inflammatory cytokine (IL-1, IL-6 and TNF) release

1992 • 101 citations

Defective macrophage antigen presentation following haemorrhage is associated with the loss of MHC class II (Ia) antigens.

1990 • 95 citations

Apoptosis in sepsis: a new target for therapeutic exploration

2001 • 91 citations

Acute hypoxia increases alveolar macrophage tumor necrosis factor activity and alters NF-κB expression

1999 • 88 citations

Comparison of plasma cytokine levels in rats subjected to superior mesenteric artery occlusion or hemorrhagic shock.

1995 • 87 citations

Ischemia: from acidosis to oxidation

1993 • 87 citations

Markers of inflammation in sepsis

2002 • 85 citations

The B7–CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system

1999 • 74 citations

Detrimental effect of nitric oxide synthase inhibition during endotoxemia may be caused by high levels of tumor necrosis factor and interleukin-6.

1994 • 69 citations

Sepsis Research in the Next Millennium: Concentrate on the Software Rather than the Hardware

2002 • 69 citations

Regulation of self-tolerance by CD80/CD86 interactions

1997 • 57 citations

Acute release of cytokines is proportional to tissue injury induced by surgical trauma and shock in rats

1991 • 56 citations

INTERACTIONS OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES (CaMK) AND EXTRACELLULAR-REGULATED KINASE (ERK) IN MONOCYTE ADHERENCE AND TNFα PRODUCTION

2000 • 54 citations

IL-4–induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis

2000 • 51 citations

Alterations of ambient oxygen tension modulate the expression of tumor necrosis factor and macrophage inflammatory protein-1 alpha from murine alveolar macrophages.

1995 • 49 citations

Effects of laparotomy on systemic macrophage function

1992 • 49 citations

Influence of Hypoxia and Glucose Deprivation on Tumour Necrosis Factor-Alpha and Granulocyte- Macrophage Colony-Stimulating Factor Expression in Human Cultured Monocytes

1998 • 45 citations

Immune Suppression in Polymicrobial Sepsis: Differential Regulation of Th1 and Th2 Responses by p38 MAPK

2000 • 44 citations

Primary Structure and Functional Characterization of a Soluble, Alternatively Spliced Form of B7-1

2000 • 44 citations

Anti-Shock Effects of Human Superoxide Dismutase in Splanchnic Artery Occlusion (SAO) Shock

1988 • 39 citations

Detection of a Soluble Form of B7-1 (CD80) in Synovial Fluid from Patients with Arthritis Using Monoclonal Antibodies against Distinct Epitopes of Human B7-1

1998 • 31 citations

Effects of laparotomy on systemic macrophage function.

1992 • 29 citations

Bacterial Translocation to the Thoracic Duct in a Setting of Ischemia, Partial Resection and Reperfusion of the Porcine Liver

1999 • 26 citations

CD80 Costimulation Is Required for Th2 Cell Cytokine Production But Not for Antigen-Specific Accumulation and Migration into the Lung

2001 • 21 citations

ACTIVATION OF HUMAN DENDRITIC CELLS BY PORCINE AORTIC ENDOTHELIAL CELLS

2001 • 16 citations

The pattern of inflammation in rat sepsis due to enterotoxin-producing Staphylococcus aureus: a comparison with ischemia-reperfusion injury.

1996 • 8 citations

Ex vivo secretion of tumor necrosis factor and interleukin-2 by rat splenocytes after intestinal ischemia and shock.

1992 • 6 citations

Enhancement of Antigen Driven Lymphocyte Proliferation Secondary to GP41-Induced B7 Expression on Adherent Monocytes

2001 • 4 citations