The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd

1995 • 5,571 citations

The complete genome sequence of the Gram-positive bacterium Bacillus subtilis

1997 • 3,613 citations

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1996 • 1,660 citations

PEST sequences and regulation by proteolysis

1996 • 1,606 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus

1997 • 1,417 citations

Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)

1998 • 1,051 citations

Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36.

1993 • 982 citations

Physiological roles of ketone bodies as substrates and signals in mammalian tissues.

1980 • 963 citations

Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein

1994 • 854 citations

The glucose transporter family: structure, function and tissue-specific expression

1993 • 773 citations

Transport of lactate and other monocarboxylates across mammalian plasma membranes

1993 • 736 citations

Evidence Supporting the Existence of an Activity-Dependent Astrocyte-Neuron Lactate Shuttle

1998 • 696 citations

Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes

1997 • 685 citations

Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: Implications for the Cori cycle

1994 • 563 citations

Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences

1995 • 553 citations

Hypoxic Regulation of Lactate Dehydrogenase A

1995 • 551 citations

Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family

1998 • 545 citations

The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors

1975 • 519 citations

Lactate transport in skeletal muscle — role and regulation of the monocarboxylate transporter

1999 • 431 citations

Exercise regulation of glucose transport in skeletal muscle

1997 • 422 citations

Lactate released by Muller glial cells is metabolized by photoreceptors from mammalian retina

1995 • 401 citations

Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by α-cyano-4-hydroxycinnamate (Short Communication)

1974 • 372 citations

Preferential Utilization of Acetate by Astrocytes Is Attributable to Transport

1998 • 362 citations

Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past

1998 • 354 citations

cDNA Cloning of MCT2, a Second Monocarboxylate Transporter Expressed in Different Cells than MCT1

1995 • 341 citations

Comparison of Lactate Transport in Astroglial Cells and Monocarboxylate Transporter 1 (MCT 1) Expressing Xenopus laevis Oocytes

1997 • 334 citations

Glucose Generates Sub-plasma Membrane ATP Microdomains in Single Islet β-Cells

1999 • 310 citations

Lactate-proton cotransport in skeletal muscle

1997 • 304 citations

Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH

1998 • 304 citations

Lactic Acid Efflux from White Skeletal Muscle Is Catalyzed by the Monocarboxylate Transporter Isoform MCT3

1998 • 293 citations

Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats

1997 • 285 citations

Mammalian passive glucose transporters: members of an ubiquitous family of active and passive transport proteins

1993 • 279 citations

Expression of monocarboxylate transporter mRNAs in mouse brain: Support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain

1998 • 279 citations

Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes

1999 • 272 citations

Computer-aided analyses of transport protein sequences: gleaning evidence concerning function, structure, biogenesis, and evolution

1994 • 263 citations

KINETICS OF BLOOD‐BRAIN BARRIER TRANSPORT OF PYRUVATE, LACTATE AND GLUCOSE IN SUCKLING, WEANLING AND ADULT RATS

1979 • 260 citations

Molecular mechanisms for the control of translation by insulin

1997 • 257 citations

Phylogenetic characterization of novel transport protein families revealed by genome analyses

1999 • 233 citations

Low-Flow Ischemia Leads to Translocation of Canine Heart GLUT-4 and GLUT-1 Glucose Transporters to the Sarcolemma In Vivo

1997 • 232 citations

Recent Advances in Blood-Brain Barrier Transport

1988 • 230 citations

Effect of high-intensity exercise training on lactate/H⁺ transport capacity in human skeletal muscle

1999 • 228 citations

Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport <scp>l</scp>‐lactate as well as butyrate

1998 • 218 citations

Transport of pyruvate nad lactate into human erythrocytes. Evidence for the involvement of the chloride carrier and a chloride-independent carrier

1976 • 214 citations

Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning

1998 • 209 citations

Human Monocarboxylate Transporter 2 (MCT2) Is a High Affinity Pyruvate Transporter

1998 • 201 citations

Monocarboxylate transport in erythrocytes

1982 • 200 citations

The specificity and metabolic implications of the inhibition of pyruvate transport in isolated mitochondria and intact tissue preparations by α-Cyano-4-hydroxycinnamate and related compounds

1975 • 195 citations

Role of the lactate transporter (MCT1) in skeletal muscles

1996 • 193 citations

Mechanisms regulating the transport of acetic acid in Saccharomyces cerevisiae

1996 • 192 citations

The Kinetics, Substrate, and Inhibitor Specificity of the Monocarboxylate (Lactate) Transporter of Rat Liver Cells Determined Using the Fluorescent Intracellular pH Indicator, 2′,7′-Bis(carboxyethyl)-5(6)-carboxyfluorescein

1996 • 175 citations

Glycophorin A facilitates the expression of human band 3-mediated anion transport in Xenopus oocytes.

1992 • 174 citations

Transport of lactate and other short-chain monocarboxylates in the yeast Saccharomyces cerevisiae

1987 • 173 citations

The Lactate-Proton Symport of Saccharomyces cerevisiae Is Encoded by JEN1

1999 • 171 citations

Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE

1998 • 170 citations

The MRC OX‐47 antigen is a member of the immunoglobulin superfamily with an unusual transmembrane sequence

1991 • 170 citations

Monocarboxylate transporter (MCT1) abundance in brains of suckling and adult rats: a quantitative electron microscopic immunogold study

1999 • 168 citations

Regulation of pyruvate metabolism in mammalian tissues.

1979 • 166 citations

Mechanisms of pHi recovery after global ischemia in the perfused heart.

1993 • 165 citations

Distribution of the lactate/H⁺ transporter isoforms MCT1 and MCT4 in human skeletal muscle

1999 • 147 citations

Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation

1997 • 147 citations

Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate

1998 • 147 citations

Characterization of the third member of the MCAT family of cationic amino acid transporters. Identification of a domain that determines the transport properties of the MCAT proteins.

1993 • 145 citations

Identification of a Unique Monocarboxylate Transporter (MCT3) in Retinal Pigment Epithelium

1997 • 142 citations

Monocarboxylate transporter expression in mouse brain

1998 • 136 citations

The kinetics, substrate and inhibitor specificity of the lactate transporter of Ehrlich-Lettre tumour cells studied with the intracellular pH indicator BCECF

1994 • 132 citations

Training intensity-dependent and tissue-specific increases in lactate uptake and MCT-1 in heart and muscle

1998 • 131 citations

Studies of the membrane topology of the rat erythrocyte H+/lactate cotransporter (MCT1)

1996 • 128 citations

Expression of the monocarboxylate transporter MCT2 by rat brain glia

1998 • 127 citations

cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function

1992 • 124 citations

Three overlapping lct genes involved in L-lactate utilization by Escherichia coli

1993 • 122 citations

Distribution of monocarboxylate transporters MCT1 and MCT2 in rat retina

1999 • 121 citations

Mitochondrial metabolite transporters

1996 • 120 citations

Mitochondrial pyruvate transport and its hormonal regulation

1980 • 119 citations

Yeast nutrient transporters

1997 • 118 citations

Cellular and subcellular expression of monocarboxylate transporters in the pigment epithelium and retina of the rat

1999 • 116 citations

Tissue specific variants of glutamate transporter GLT‐1

1997 • 115 citations

Asparagine-linked oligosaccharides are localized to single extracytosolic segments in multi-span membrane glycoproteins

1994 • 113 citations

cDNA Cloning and Functional Characterization of Rat Intestinal Monocarboxylate Transporter

1995 • 110 citations

Chronic electrical stimulation increases MCT1 and lactate uptake in red and white skeletal muscle

1997 • 106 citations

Brain Anaerobic Lactate Production: A Suicide Note or a Survival Kit?

1998 • 104 citations

A novel transmembrane transporter encoded by the XPCT gene in Xq13.2

1994 • 104 citations

A Large PEST-like Sequence Directs the Ubiquitination, Endocytosis, and Vacuolar Degradation of the Yeast a-Factor Receptor

1998 • 102 citations

HT7, Neurothelin, Basigin, gp42 and OX-47 - many names for one developmentally regulated immuno-globulin-like surface glycoprotein on blood-brain barrier endothelium, epithelial tissue barriers and neurons

1992 • 102 citations

Lactate transport studied in sarcolemmal giant vesicles from human muscle biopsies: relation to training status

1994 • 100 citations

The kinetics of transport of lactate and pyruvate into isolated cardiac myocytes from guinea pig. Kinetic evidence for the presence of a carrier distinct from that in erythrocytes and hepatocytes

1989 • 97 citations

cDNA Cloning of the Human Monocarboxylate Transporter 1 and Chromosomal Localization of the SLC16A1 Locus to 1p13.2-p12

1994 • 96 citations

Three N-terminal Variants of the AE2 Cl-/HCO3- Exchanger Are Encoded by mRNAs Transcribed from Alternative Promoters

1996 • 93 citations

Organizational characteristics and information content of an archaeal genome: 156kb of sequence from Sulfolobus solfataricus P2

1996 • 87 citations

Cotransport of H+, lactate and H2O by membrane proteins in retinal pigment epithelium of bullfrog.

1996 • 83 citations

Increments in skeletal muscle GLUT-1 and GLUT-4 after endurance training in humans

1996 • 82 citations

Helix 8 and Helix 10 Are Involved in Substrate Recognition in the Rat Monocarboxylate Transporter MCT1

1999 • 80 citations

Lactate Transporter Defect: A New Disease of Muscle

1986 • 74 citations

Interaction of the Erythrocyte Lactate Transporter (Monocarboxylate Transporter 1) with an Integral 70-kDa Membrane Glycoprotein of the Immunoglobulin Superfamily

1997 • 74 citations

The effects of glycophorin A on the expression of the human red cell anion transporter (band 3) in Xenopus oocytes

1994 • 72 citations

cDNA cloning of MCT1, a monocarboxylate transporter from rat skeletal muscle

1995 • 72 citations

Lactate transport studied in sarcolemmal giant vesicles from rats: effect of training

1993 • 72 citations

Effects of changes of intracellular pH on contraction in sheep cardiac Purkinje fibers.

1987 • 71 citations

A strong carboxylate-arginine interaction is important in substrate orientation and recognition in lactate dehydrogenase

1987 • 67 citations

Structure−Function Analysis of Liver-Type (GLUT2) and Brain-Type (GLUT3) Glucose Transporters: Expression of Chimeric Transporters in Xenopus Oocytes Suggests an Important Role for Putative Transmembrane Helix 7 in Determining Substrate Selectivity

1996 • 66 citations

Isoforms of the Na-K-2Cl cotransporter in murine TAL II. Functional characterization and activation by cAMP

1999 • 66 citations

Lactate Transport by Cortical Synaptosomes from Adult Rat Brain: Characterization of Kinetics and Inhibitor Specificity

1998 • 65 citations

Analysis of a Gene Encoding Two Glycine Transporter Variants Reveals Alternative Promoter Usage and a Novel Gene Structure

1998 • 64 citations

Distribution of the integral plasma membrane glycoprotein CE9 (MRC OX-47) among rat tissues and its induction by diverse stimuli of metabolic activation

1995 • 61 citations

Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettré tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function

1996 • 61 citations

Overexpression of lactate dehydrogenase A attenuates glucose‐induced insulin secretion in stable MIN‐6 β‐cell lines

1998 • 59 citations

Substrate and inhibitor specificities of the monocarboxylate transporters of single rat heart cells

1996 • 59 citations

N-terminal protein sequence analysis of the rabbit erythrocyte lactate transporter suggests identity with the cloned monocarboxylate transport protein MCT1

1994 • 58 citations

Substrate and inhibitor specificity of monocarboxylate transport into heart cells and erythrocytes. Further evidence for the existence of two distinct carriers

1990 • 58 citations

Regulation of gene expression for translation initiation factor eIF-2α: importance of the 3′ untranslated region

1996 • 57 citations

Kinetic analysis of l-lactate transport in human erythrocytes via the monocarboxylate-specific carrier system

1983 • 57 citations

Alternative splicing of the glutamate transporter EAAT2 (GLT-1)

1998 • 56 citations

A microelectrode study of the mechanisms of L‐lactate entry into and release from frog sartorius muscle.

1988 • 56 citations

Molecular biology of the cardiac sodium/hydrogen exchanger

1995 • 56 citations

Kinetics of the sarcolemmal lactate carrier in single heart cells using BCECF to measure pHi

1994 • 56 citations

Endurance training increases skeletal muscle lactate transport

1993 • 56 citations

A Novel Aromatic-Ring-Hydroxylating Dioxygenase from the Diterpenoid-Degrading Bacterium Pseudomonas abietaniphila BKME-9

1999 • 55 citations

Characterization of the inhibition by stilbene disulphonates and phloretin of lactate and pyruvate transport into rat and guinea-pig cardiac myocytes suggests the presence of two kinetically distinct carriers in heart cells

1993 • 53 citations

Identification and partial purification of the erythrocyte <scp>l</scp>-lactate transporter

1992 • 53 citations

Cellular and Subcellular Expression of the Monocarboxylate Transporter MCT1 in Rat Heart

1997 • 51 citations

Regulation of intracellular pH in the myocardium; relevance to pathology

1989 • 51 citations

Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5′ end heterogeneity

1998 • 51 citations

Purification of the Lysosomal Sialic Acid Transporter

1998 • 50 citations

A rabbit erythrocyte membrane protein associated with L-lactate transport.

1982 • 49 citations

Lactate Transport and Lactate Transporters in Skeletal Muscle

1997 • 48 citations

[18] Monocarboxylate transport in red blood cells: Kinetics and chemical modification

1989 • 47 citations

Evidence for a regulatory protein involved in the increased activity of system A for neutral amino acid transport in osmotically stressed mammalian cells.

1994 • 45 citations

Reduced lactate transport in denervated rat skeletal muscle

1995 • 43 citations

A teratocarcinoma glycoprotein carrying a developmentally regulated carbohydrate marker is a member of the immunoglobulin gene superfamily.

1988 • 43 citations

Inhibition of pyruvate transport by fatty acids in isolated cells from rat small intestine

1975 • 42 citations

Reciprocal GLUT-1 and GLUT-4 expression and glucose transport in denervated muscles

1996 • 41 citations

Developmental Expression and Molecular Cloning of REMP, a Novel Retinal Epithelial Membrane Protein

1995 • 40 citations

The contribution of intracellular acidosis to the decline of developed pressure in ferret hearts exposed to cyanide.

1987 • 40 citations

Embigin, a developmentally expressed member of the immunoglobulin super family, is also expressed during regression of prostate and mammary gland

1997 • 37 citations

Mapping, sequence, and apparent lack of function of araJ, a gene of the Escherichia coli arabinose regulon

1991 • 35 citations

Reconstitution of the <scp>l</scp>-lactate carrier from rat and rabbit erythrocyte plasma membranes

1988 • 29 citations

Cloning of the rabbit homologue of mouse ‘basigin’ and rat ‘OX-47’: kidney cell type-specific expression, and regulation in collecting duct cells

1996 • 29 citations

The 25 -36 region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes

1996 • 28 citations

Effect of overexpressing GLUT-1 and GLUT-4 on insulin- and contraction-stimulated glucose transport in muscle

1996 • 28 citations

Lactate transport studied in sarcolemmal giant vesicles from rat skeletal muscles: effect of denervation

1995 • 27 citations

Effect of electrical stimulation patterns on glucose transport in rat muscles

1996 • 27 citations

Protein Kinase A Stimulates Binding of Multiple Proteins to a U-Rich Domain in the 3′-Untranslated Region of Lactate Dehydrogenase A mRNA That Is Required for the Regulation of mRNA Stability

1998 • 26 citations

Lactate-proton co-transport and its contribution to interstitial acidification during hypoxia in isolated rat spinal roots

1993 • 25 citations

Cloning and Localization of the MurineXpctGene: Evidence for Complex Rearrangements during the Evolution of the Region around theXistGene

1998 • 22 citations

Alternative-substrate inhibition of l-lactate transport via the monocarboxylate-specific carrier system in human erythrocytes

1985 • 22 citations

Membrane polypeptide in rabbit erythrocytes associated with the inhibition of L-lactate transport by a synthetic anhydride of lactic acid

1985 • 22 citations

N-hydroxysulfosuccinimido active esters and the L-(+)-lactate transport protein in rabbit erythrocytes

1986 • 21 citations

Transport of organic anions by the lysosomal sialic acid transporter: a functional approach towards the gene for sialic acid storage disease

1999 • 21 citations

Regulation of glucose transporters GLUT-4 and GLUT-1 gene transcription in denervated skeletal muscle

1998 • 20 citations

Lactate/H + transport kinetics in rat skeletal muscle related to fibre type and changes in transport capacity

1998 • 20 citations

Lactate transport in insulin-secreting β-cells: Contrast between rat islets and HIT-T15 insulinoma cells

1992 • 20 citations

XI. Yeast sequencing reports. Sequencing of a 13·2 kb segment next to the left telomere of yeast chromosome XI revealed five open reading frames and recent recombination events with the right arms of chromosomes III and V

1994 • 19 citations

<scp>XIV</scp>. Yeast sequencing reports. A 43·5 kb segment of yeast chromosome XIV, which contains MFA2, MEP2, CAP/SRV2, NAM9, FKB1/FPR1/RBP1, MOM22 and CPT1, predicts an adenosine deaminase gene and 14 new open reading frames

1995 • 16 citations

Functional evidence for a monocarboxylate transporter (MCT) in strial marginal cells and molecular evidence for MCT1 and MCT2 in stria vascularis

1997 • 15 citations

Genomic Structure and Developmental Expression of the Chicken Monocarboxylate Transporter MCT3 Gene

1998 • 14 citations

Mechanism of hypoxia-stimulated glucose transport in rat skeletal muscle: potential role of glycogen

1998 • 14 citations

Effect of prior eccentric contractions on lactate/H⁺ transport in rat skeletal muscle

1998 • 14 citations

Reconstitution of lactate proton symport activity in plasma membrane vesicles from the yeastCandida utilis

1996 • 13 citations

Vestibular Dark Cells Contain an H + /Monocarboxylate − Cotransporter in Their Apical and Basolateral Membrane

1998 • 10 citations