Deduction of kinetic mechanism in multisubstrate enzyme reactions from tritium isotope effects. Application to dopamine beta-hydroxylase.

3,4-Dihydroxyphenylethylamine β-Hydroxylase

1965 • 451 citations

A simple method for the isolation of adrenal chromaffin granules on a large scale

1967 • 439 citations

Steady-state analysis of kinetic isotope effects in enzymic reactions

1975 • 376 citations

Partition analysis and concept of net rate constants as tools in enzyme kinetics

1975 • 323 citations

A fluorimetric micromethod for differential estimation of adrenaline and noradrenaline.

1955 • 300 citations

730. The salting-out of non-electrolytes. Part II. The effect of variation in non-electrolyte

1952 • 235 citations

Isotope Effects on Reaction Rates.

1961 • 187 citations

What limits the rate of an enzyme-catalyzed reaction

1975 • 148 citations

The Oxygenated Form of l-Tryptophan 2,3-Dioxygenase as Reaction Intermediate

1970 • 136 citations

Kinetic studies of the enzymic dopamine β-hydroxylation reaction

1968 • 119 citations

Uncatalyzed rates of enolization of dihydroxyacetone phosphate and of glyceraldehyde 3-phosphate in neutral aqueous solution. Quantitative assessment of the effectiveness of an enzyme catalyst

1975 • 73 citations

Evidence for an Oxygenated Intermediate in the Tryptophan Pyrrolase Reaction

1967 • 63 citations

Kinetic Isotope Effects in Enzymology

1978 • 62 citations

Dophamine β‐Hhydroxylase: Evidence against a ping‐pong mechanism

1974 • 41 citations

Dopamine β‐monooxygenase: electron paramagnetic resonance and oxidation‐reduction properties of the enzyme‐bound copper

1978 • 38 citations

Oxygenated Form of Protocatechuate 3,4-Dioxygenase, a Non-heme Iron-containing Dioxygenase, as Reaction Intermediate

1971 • 36 citations

ELECTRONIC ASPECTS OF CATALYSIS OF THE OXYGENASES

1969 • 22 citations

Isotope effects in the hydroxylation of phenylethylamine by dopamine .beta.-hydroxylase

1974 • 21 citations

New Spectral Species of l-Lysine Monooxygenase, a Flavoprotein

1971 • 19 citations

Dopamine β-monooxygenase: Reduced enzyme needs additional reductant for completion of the catalytic cycle

1978 • 9 citations