The Essential Role of Saccharomyces cerevisiae CDC6 Nucleotide-binding Site in Cell Growth, DNA Synthesis, and Orc1 Association

CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors

1997 • 2,201 citations

Yeast/E. coli shuttle vectors with multiple unique restriction sites

1986 • 1,399 citations

The molecular biology of the yeast saccharomyces: Life cycle and inheritance

1982 • 1,361 citations

[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors

1983 • 1,093 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

Components and Dynamics of DNA Replication Complexes in S. cerevisiae: Redistribution of MCM Proteins and Cdc45p during S Phase

1997 • 743 citations

Two steps in the assembly of complexes at yeast replication origins in vivo

1994 • 566 citations

ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins.

1986 • 538 citations

Cell Cycle Control of DNA Replication

1996 • 512 citations

Loading of an Mcm Protein onto DNA Replication Origins Is Regulated by Cdc6p and CDKs

1997 • 503 citations

Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast

1997 • 496 citations

The fission yeast cdc18+ gene product couples S phase to START and mitosis

1993 • 446 citations

Viral proteins containing the purine NTP-binding sequence pattern

1989 • 426 citations

Isolation of ORC6 , a Component of the Yeast Origin Recognition Complex by a One-Hybrid System

1993 • 416 citations

Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a ‘reductional’ anaphase in the budding yeast Saccharomyces cerevisiae.

1995 • 402 citations

INITIATION OF DNA REPLICATION IN EUKARYOTIC CELLS

1997 • 399 citations

ALTERED FIDELITY OF MITOTIC CHROMOSOME TRANSMISSION IN CELL CYCLE MUTANTS OF S. CEREVISIAE

1985 • 390 citations

The Xenopus Cdc6 Protein Is Essential for the Initiation of a Single Round of DNA Replication in Cell-Free Extracts

1996 • 387 citations

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

1996 • 362 citations

Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants

1997 • 359 citations

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome

1995 • 357 citations

A group of interacting yeast DNA replication genes.

1991 • 325 citations

Phosphate‐binding sequences in nucleotide‐binding proteins

1985 • 295 citations

Mutation of lysine-48 to arginine in the yeast RAD3 protein abolishes its ATPase and DNA helicase activities but not the ability to bind ATP.

1988 • 263 citations

p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast

1995 • 259 citations

The multidomain structure of Orc1 p reveals similarity to regulators of DNA replication and transcriptional silencing

1995 • 259 citations

Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase

1998 • 251 citations

Conserved Initiator Proteins in Eukaryotes

1995 • 246 citations

Coordinate Binding of ATP and Origin DNA Regulates the ATPase Activity of the Origin Recognition Complex

1997 • 243 citations

Regulation of CDK/cyclin complexes during the cell cycle

1997 • 214 citations

Genetic control of the cell division cycle in yeast

1971 • 214 citations

Nucleotide-Dependent Prereplicative Complex Assembly by Cdc6p, a Homolog of Eukaryotic and Prokaryotic Clamp-Loaders

1998 • 202 citations

Strategies and Applications of in Vitro Mutagenesis

1985 • 192 citations

Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.

1995 • 179 citations

ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae.

1996 • 166 citations

A human protein related to yeast Cdc6p

1997 • 147 citations

Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae.

1992 • 145 citations

Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division.

1992 • 143 citations

ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae.

1996 • 141 citations

Accurate initiation at RNA polymerase II promoters in extracts from Saccharomyces cerevisiae.

1987 • 141 citations

Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases.

1996 • 121 citations

The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes a ATP/GTPase controlling S phase initiation.

1994 • 96 citations

Molecular Cloning of Saccharomyces cerevisiae CDC6 Gene

1989 • 60 citations

Cdc6p establishes and maintains a state of replication competence during G1 phase

1997 • 59 citations

CDC6 mRNA fluctuates periodically in the yeast cell cycle.

1990 • 56 citations

A protocol for using T7 DNA polymerase in oligonucleotide site-directed mutagenesis.

1990 • 26 citations

Intracellular Location of theSaccharomyces cerevisiae CDC6Gene Product

1996 • 22 citations

Mutation Analysis ofSaccharomyces cerevisiae CDC6Promoter: Defining Its UAS Domain and Cell Cycle Regulating Element

1993 • 13 citations

Pulsed Field Gel Electrophoresis Labeling Method to Study the Pattern of Saccharomyces cerevisiae Chromosomal DNA Synthesis During the G1/S Phase of the Cell Cycle

1995 • 10 citations

Saccharomyces cerevisiae Cdc6 Stimulates Abf1 DNA Binding Activity

1998 • 8 citations