Weak Proinsulin Peptide–Major Histocompatibility Complexes Are Targeted in Autoimmune Diabetes in Mice

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

1967 • 2,783 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 • 744 citations

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

2004 • 482 citations

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

1999 • 426 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

Secretion of Proinsulin C-Peptide by Pancreatic β Cells and its Circulation in Blood

1969 • 294 citations

Pancreatic Lymph Nodes Are Required for Priming of β Cell Reactive T Cells in NOD Mice

2002 • 290 citations

A defect in central tolerance in NOD mice

2001 • 272 citations

Insulin Expression Levels in the Thymus Modulate Insulin-Specific Autoreactive T-Cell Tolerance

2002 • 260 citations

Development of Spontaneous Autoimmune Peripheral Polyneuropathy in B7-2–Deficient Nod Mice

2001 • 225 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.

1996 • 217 citations

Structural Basis of Peptide Binding and Presentation by the Type I Diabetes-Associated MHC Class II Molecule of NOD Mice

2000 • 197 citations

An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction

1993 • 182 citations

Defective Central Tolerance Induction in NOD Mice: Genomics and Genetics

2005 • 179 citations

Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes

2002 • 140 citations

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

2004 • 133 citations

High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy

2004 • 126 citations

Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients

2005 • 122 citations

Evidence That a Peptide Spanning the B-C Junction of Proinsulin Is an Early Autoantigen Epitope in the Pathogenesis of Type 1 Diabetes

2001 • 116 citations

Autoreactivity of T cells from nonobese diabetic mice: An I-A^g7-dependent reaction

1998 • 115 citations

High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy

2004 • 107 citations

The Insulin-Specific T Cells of Nonobese Diabetic Mice Recognize a Weak MHC-Binding Segment in More Than One Form

2007 • 100 citations

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

2003 • 98 citations

Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity

2003 • 92 citations

T cell Autoreactivity to Proinsulin Epitopes in Diabetic Patients and Healthy Subjects

1999 • 76 citations

In APCs, the Autologous Peptides Selected by the Diabetogenic I-Ag7 Molecule Are Unique and Determined by the Amino Acid Changes in the P9 Pocket

2002 • 76 citations

Analysis of the Role of Variation of Major Histocompatibility Complex Class II Expression on Nonobese Diabetic (NOD) Peripheral T Cell Response

1998 • 76 citations

Dual Overlapping Peptides Recognized by Insulin Peptide B:9–23 T Cell Receptor AV13S3 T Cell Clones of the NOD Mouse

2000 • 63 citations

HLA-DR binding analysis of peptides from islet antigens in IDDM.

1998 • 63 citations

T Cell Response to Preproinsulin I and II in the Nonobese Diabetic Mouse

2002 • 60 citations

Sialadenitis in nonobese diabetic mice: Transfer into syngeneic healthy neonates by splenic T lymphocytes

1991 • 60 citations

Absence of Lymph Nodes inNODMice Treated With Lymphotoxin-β Receptor Immunoglobulin Protects From Diabetes

2004 • 58 citations

The non-obese diabetic (NOD) mouse: An animal model for autoimmune thyroiditis

2009 • 55 citations

Predominantly Recognized ProInsulin T Helper Cell Epitopes in Individuals With and Without Islet Cell Autoimmunity

2002 • 48 citations

Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?

2007 • 44 citations

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

2003 • 36 citations

Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and β-islet cells

1999 • 30 citations

Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation

2002 • 24 citations

Type I diabetes in NOD mice is not associated with insulin-specific, autoreactive T cells

1989 • 14 citations

Adrenalitis in the Non-obese Diabetic Mouse

2002 • 12 citations